论文信息 - Simulation of platelet deposition in disturbed flow

Simulation of platelet deposition in disturbed flow

We have developed a two-dimensional computational model of platelet-mediated biomaterial thrombosis. When applied to plane Poiseuille flow over collagen, it showed very good agreement with experimental results. Here, we attempt to simulate platelet deposition onto collagen in the presence of disturbed flow in a tubular expansion. At 0% hematocrit, good agreement with experiments is obtained for the recirculation zone, but not for the fully-developed downstream zone At 20% hematocrit, poor agreement is observed unless the platelet-surface reaction coefficients are altered. In both cases, it appears the deficiencies are due to incomplete modeling of platelet transport mechanisms.

James F. Antaki | William R. Wagner | Erik N. Sorensen | Gregory Burgreen

[1] R M Heethaar,et al. Blood platelets are concentrated near the wall and red blood cells, in the center in flowing blood. , 1988, Arteriosclerosis.

[2] James F. Antaki,et al. Computational Simulation of Platelet Deposition and Activation: II. Results for Poiseuille Flow over Collagen , 1999, Annals of Biomedical Engineering.

[3] H. Goldsmith,et al. Adhesion of human platelets to collagen on the walls distal to a tubular expansion. , 1979, Microvascular research.

[4] James F. Antaki,et al. Computational Simulation of Platelet Deposition and Activation: I. Model Development and Properties , 1999, Annals of Biomedical Engineering.