Acoustofluidics 21: ultrasound-enhanced immunoassays and particle sensors.

In part 21 of the tutorial series "Acoustofluidics--exploiting ultrasonic standing wave forces and acoustic streaming in microfluidic systems for cell and particle manipulation", we review applications of ultrasonic standing waves used for enhancing immunoassays and particle sensors. The paper covers ultrasonic enhancement of bead-based immuno-agglutination assays, bead-based immuno-fluorescence assays, vibrational spectroscopy sensors and cell deposition on a sensor surface.

[1]  J. Popp,et al.  Raman acoustic levitation spectroscopy of red blood cells and Plasmodium falciparum trophozoites. , 2007, Lab on a chip.

[2]  M. Zourob,et al.  Optical leaky waveguide sensor for detection of bacteria with ultrasound attractor force. , 2005, Analytical chemistry.

[3]  W. Coakley,et al.  Detection of meningococcal antigen by latex agglutination. , 2001, Methods in molecular medicine.

[4]  Marc P Y Desmulliez,et al.  Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: a review. , 2011, Lab on a chip.

[5]  P. Stewart,et al.  Biofilm removal caused by chemical treatments , 2000 .

[6]  Stefan Radel,et al.  Ultrasonic particle manipulation exploited in on-line infrared spectroscopy of (cell) suspensions , 2008, Elektrotech. Informationstechnik.

[7]  Martyn Hill,et al.  Flexible acoustic particle manipulation device with integrated optical waveguide for enhanced microbead assays. , 2009, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[8]  C. E. Looney,et al.  Novel shell/core particles for automated turbidimetric immunoassays. , 1984, Clinical chemistry.

[9]  Introductory Lecture Acoustic interactions from Faraday's crispations to MEMS , 1997 .

[10]  A Lenshof,et al.  Acoustofluidics 5: Building microfluidic acoustic resonators. , 2012, Lab on a chip.

[11]  M. Stevens,et al.  Raman microspectroscopy for non-invasive biochemical analysis of single cells. , 2007, Biochemical Society transactions.

[12]  John P Nolan,et al.  Suspension array technology: evolution of the flat-array paradigm. , 2002, Trends in biotechnology.

[13]  E. Benes,et al.  Rapid agglutination testing in an ultrasonic standing wave. , 1993, Journal of immunological methods.

[14]  Kinetics of the initial stage of immunoagglutionation studied with the scanning flow cytometer , 2008, 0807.4645.

[15]  Faraday Discuss , 1985 .

[16]  Bernhard Meyer,et al.  APPROACHES TO PREVENTION, REMOVAL AND KILLING OF BIOFILMS , 2003 .

[17]  P. Salmon,et al.  Real-time analyte monitoring of a fungal fermentation, at pilot scale, using in situ mid-infrared spectroscopy , 2001 .

[18]  S. Brown,et al.  Safety and cleaning of medical materials and devices. , 2000, Journal of biomedical materials research.

[19]  Adrian Neild,et al.  Manipulation of micrometer sized particles within a micromachined fluidic device to form two-dimensional patterns using ultrasound. , 2007, The Journal of the Acoustical Society of America.

[20]  R. Ekins,et al.  Multi-analyte immunoassay. , 1989, Journal of pharmaceutical and biomedical analysis.

[21]  J. Chalmers,et al.  Handbook of vibrational spectroscopy , 2002 .

[22]  H M Hertz,et al.  Ultrasonic enhancement of bead-based bioaffinity assays. , 2006, Lab on a chip.

[23]  Jeremy J Hawkes,et al.  Ultrasonic deposition of cells on a surface. , 2004, Biosensors & bioelectronics.

[24]  Stefan Radel,et al.  Ultrasonic trapping of microparticles in suspension and reaction monitoring using Raman microspectroscopy. , 2007, Analytical chemistry.

[25]  D. Stollar.  Serologic Phenomena in Rheumatoid Arthritis: A Review. , 1960, Canadian Medical Association journal.

[26]  Martyn Hill,et al.  Acoustofluidics 9: Modelling and applications of planar resonant devices for acoustic particle manipulation. , 2012, Lab on a chip.

[27]  Andrei V Chernyshev,et al.  Fluorescence-microscopy-based image analysis for analyte-dependent particle doublet detection in a single-step immunoagglutination assay. , 2005, Analytical biochemistry.

[28]  John E. Bertie,et al.  Infrared Intensities of Liquids XX: The Intensity of the OH Stretching Band of Liquid Water Revisited, and the Best Current Values of the Optical Constants of H2O(l) at 25°C between 15,000 and 1 cm−1 , 1996 .

[29]  A polymeric chip for micromanipulation and particle sorting by ultrasounds based on a multilayer configuration , 2010 .

[30]  Stefan Radel,et al.  Observation of particles manipulated by ultrasound in close proximity to a cone-shaped infrared spectroscopy probe. , 2010, Ultrasonics.

[31]  Pekka Hänninen,et al.  A new microvolume technique for bioaffinity assays using two-photon excitation , 2000, Nature Biotechnology.

[32]  John Arul Phillips,et al.  In Situ Monitoring of an Escherichia coli Fermentation Using a Diamond Composition ATR Probe and Mid‐infrared Spectroscopy , 1999, Biotechnology progress.

[33]  R. J. Boltryk,et al.  Robust acoustic particle manipulation: A thin-reflector design for moving particles to a surface. , 2009, The Journal of the Acoustical Society of America.

[34]  B. Lendl,et al.  Bead injection for surface enhanced Raman spectroscopy: automated on-line monitoring of substrate generation and application in quantitative analysis. , 2002, The Analyst.

[35]  B. Lendl,et al.  On-line determination of the intracellular poly(beta-hydroxybutyric acid) content in transformed Escherichia coli and glucose during PHB production using stopped-flow attenuated total reflection FT-IR spectrometry. , 2004, Analytical chemistry.

[36]  Stefan Radel,et al.  Raman spectroscopy of particles in suspension concentrated by an ultrasonic standing wave , 2008, Elektrotech. Informationstechnik.

[37]  R. Munro,et al.  Ultrasound‐enhanced latex immunoagglutination test (USELAT) for detection of capsular polysaccharide antigen of Neisseria meningitidis from CSF and plasma , 2003, Pathology.

[38]  P. Masson.  Particle counting immunoassay--an overview. , 1987, Journal of pharmaceutical and biomedical analysis.

[39]  C. Plotz,et al.  The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis. , 1956, The American journal of medicine.

[40]  Jay W. Grate,et al.  Microsphere capture and perfusion in microchannels using flexural plate wave structures , 2002, 2002 IEEE Ultrasonics Symposium, 2002. Proceedings..

[41]  Martin Wiklund,et al.  Acoustofluidics 14: Applications of acoustic streaming in microfluidic devices. , 2012, Lab on a chip.

[42]  Thomas Laurell,et al.  On-line monitoring of airborne chemistry in levitated nanodroplets: in situ synthesis and application of SERS-active Ag-Sols for trace analysis by FT-Raman spectroscopy. , 2003, Analytical chemistry.

[43]  R W Ellis,et al.  Diagnostic particle agglutination using ultrasound: a new technology to rejuvenate old microbiological methods. , 2000, Journal of medical microbiology.

[44]  Christopher Lawrence.  Pathology , 1911, The Lancet.

[45]  W. Coakley,et al.  Increased sensitivity of diagnostic latex agglutination tests in an ultrasonic standing wave field. , 1994, Journal of immunological methods.

[46]  B. Lendl,et al.  A portable FTIR-ATR process analyzer - online fermentation control , 2004, Proceedings of IEEE Sensors, 2004..

[47]  E. Benes,et al.  On Chemical and Ultrasonic Strategies to Improve a Portable FT-IR ATR Process Analyzer for Online Fermentation Monitoring , 2010, IEEE Sensors Journal.

[48]  J. Molina-Bolívar,et al.  Latex Immunoagglutination Assays , 2005 .

[49]  Jens Nielsen,et al.  On-line bioprocess monitoring – an academic discipline or an industrial tool? , 1998 .

[50]  Pekka Hänninen,et al.  Ultrasonic enrichment of microspheres for ultrasensitive biomedical analysis in confocal laser-scanning fluorescence detection , 2004 .

[51]  Tomas Hirschfeld,et al.  Internal Reflection Spectroscopy , 1967 .

[52]  Henrik Bruus,et al.  Acoustofluidics 7: The acoustic radiation force on small particles. , 2012, Lab on a chip.

[53]  Bernhard Lendl,et al.  Raman spectroscopy in chemical bioanalysis. , 2004, Current opinion in chemical biology.

[54]  W. Kapmeyer,et al.  Automated nephelometric immunoassays with novel shell/core particles , 1988 .

[55]  J Blitz.  Ultrasonics , 1967 .