Diurnal rhythm of the in vivo acetate metabolism to CO2 and nonsaponifiable lipids by neonatal chick.

The in vivo incorporation of acetate into nonsaponifiable lipids was studied in different tissues from 14-day-old chick. Total nonsaponifiable lipids (nmol/30 min/g tissue) were mainly synthesized in testicles and liver. The in vivo CO2 production from acetate by 1-day-old chick did not exhibit diurnal variations. However, in 14-day-old chick, a maximal value was observed in the middle of the light period, while a minimal value was found 9 h after the start of the dark period. No significant diurnal differences were detected in the in vivo acetate incorporation into nonsaponifiable lipids by liver and duodenal mucosa from 1-day-old chick. Nevertheless, a clear diurnal rhythm was found in liver and duodenal mucosa from 14-day-old chick, but not in brain and kidney from animals of the same age. Distribution of radioactivity from (1-14C)acetate among the different constituents of the nonsaponifiable fraction has been also studied at 3-h intervals. Cholesterol was the major sterol formed from acetate by chick liver at any time of day. In duodenal mucosa and kidney, maximal values in the percentage of cholesterol synthesized were observed during the light period.

[1]  D. González-Pacanowska,et al.  Studies on the diurnal rhythm of mevalonate metabolism by sterol and nonsterol pathways and of mevalonate-activating enzymes. , 1985, The International journal of biochemistry.

[2]  D. Fletcher.  The physiological control of appetite in fish , 1984 .

[3]  J. Segovia,et al.  Relationship between inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by cholesterol feeding and short-term changes in membrane fluidity during neonatal development. , 1984, The International journal of biochemistry.

[4]  C. Marco,et al.  Postnatal development of the sterol and nonsterol mevalonate metabolism in chick liver and kidneys. Effect of cholesterol feeding. , 1984, Annals of nutrition & metabolism.

[5]  E. García-Peregrín,et al.  The in vivo incorporation of acetate into different non-saponifiable lipids by neonatal chick tissues. , 1984, Comparative biochemistry and physiology. B, Comparative biochemistry.

[6]  E. García-Peregrín,et al.  Studies of the in vivo metabolism of mevalonic acid in the neonatal chick. , 1983, The International journal of biochemistry.

[7]  E. García-Peregrín,et al.  Incorporation of mevalonate into squalene, lanosterol and cholesterol by different neonatal chick tissues. , 1983, International Journal of Biochemistry.

[8]  E. García-Peregrín,et al.  The in vitro metabolism of mevalonate by sterol and nonsterol pathways in neonatal chick. , 1982, Comparative biochemistry and physiology. B, Comparative biochemistry.

[9]  E. García-Peregrín,et al.  A comparative study of cholesterogenic activities from acetate of neonatal chick liver, kidney and intestinal mucosa. , 1982, Comparative biochemistry and physiology. B, Comparative biochemistry.

[10]  J. Dietschy,et al.  Rates of sterol synthesis and uptake in the major organs of the rat in vivo. , 1981, Journal of lipid research.

[11]  M. D. Suárez,et al.  Different developmental patterns of 3-hydroxy-3-methylglutaryl-CoA reductase in chick tissues according to their role in cholesterogenesis. , 1981, Biology of the neonate.

[12]  A. Fogelman,et al.  Mevalonate metabolism: role of kidneys. , 1976, Science.

[13]  M. Wiley,et al.  The in vitro metabolism of mevalonate by sterol and non-sterol pathways. , 1976, The Journal of biological chemistry.

[14]  B. Ed,et al.  Biochemistry of Polyisoprenoid Biosynthesis , 1976 .

[15]  J. Nordstrom,et al.  Regulation of HMG-CoA reductase. , 1976, Advances in lipid research.

[16]  A. Fogelman,et al.  Metabolism of mevalonate in rats and man not leading to sterols. , 1975, The Journal of biological chemistry.

[17]  J. Edmond,et al.  Transfer of carbon atoms from mevalonate to n-fatty acids. , 1974, The Journal of biological chemistry.

[18]  P. Raskin,et al.  Mevalonate metabolism by renal tissue in vitro. , 1974, Journal of lipid research.

[19]  M. Siperstein,et al.  Studies of the in vivo metabolism of mevalonic acid in the normal rat. , 1973, The Journal of clinical investigation.

[20]  S. Shefer,et al.  HMG CoA reductase of intestinal mucosa and liver of the rat. , 1972, Journal of lipid research.

[21]  Marvin D. Siperstein,et al.  Regulation of cholesterol biosynthesis in normal and malignant tissues. , 1970 .

[22]  A. Kandutsch,et al.  Prevention of cyclic and triton-induced increases in hydroxymethylglutaryl coenzyme A reductase and sterol synthesis by puromycin. , 1969, The Journal of biological chemistry.