Formulation and In-Vitro Characterisation of Fast Disintegrating Tablets of Ziprosidone

The present work investigates enhancement of dissolution profile of Ziprasidone using super disintegrants like croscaramellose sodium and sodium starch glycolate. Ziprasidone fast disintegrating tablets (FDT) can be prepared direct compression method. Effect of disintegrants on disintegration and dissolution parameters was studied. Disintegrating time and dissolution parameter (T50% and T90%) decreased with increases in the level of croscarmellose sodium and sodium starch glycolate. It was concluded that the ZF6 formulation with croscaramellose sodium (6%) as super disintegrating agent shows good drug release on ziprasidone tablet formulation.