Adenosine deaminase activity in patients with ovarian neoplasms

PurposeThe aim of this study was to investigate the serum and peritoneal fluid adenosine deaminase (ADA) activity in patients with benign and malignant ovarian neoplasms.MethodsThis is a prospective cross-sectional study performed in Cukurova University, Department of Gynecologic Oncology. Eighty-four patients with ovarian mass were included in this study within 13 months. The levels of serum and peritoneal fluid ADA levels were measured and compared in patients with benign and malignant ovarian neoplasms and also low- and high-grade malignant tumors.ResultsSerum and peritoneal fluid ADA levels were found to be significantly higher in patients with ovarian cancers as compared with benign ovarian tumors (p = 0.001). Additionally, ADA levels were found to be significantly different according to the histopathological subtypes and grade of ovarian cancers. However, there was no significant difference for ADA levels between the benign and low-grade malignant tumors. There was an important correlation between the peritoneal fluid and serum ADA levels.ConclusionsSerum and peritoneal fluid ADA levels were found to be higher in malignant ovarian neoplasms. This finding may be useful to understand the biochemically characteristics of malignant ovarian tumors and ADA may be a useful biomarker in diagnosis and management of ovarian tumors.

[1]  H. Biri,et al.  Activities of DNA turnover and free radical metabolizing enzymes in cancerous human prostate tissue. , 1999, Cancer investigation.

[2]  Y. Kuwabara,et al.  Serum Adenosine Deaminase Activity in Women with Pre-Eclampsia , 2003, Gynecologic and Obstetric Investigation.

[3]  Hans Ulrich Bergmeyer,et al.  Methods of Enzymatic Analysis , 2019 .

[4]  R. Leoncini,et al.  Enzyme activities controlling adenosine levels in normal and neoplastic tissues , 2004, Medical oncology.

[5]  M. B. Amar,et al.  Peritoneal tubercu losis , 2011 .

[6]  S. E. Lind,et al.  Adenosine-mediated killing of cultured epithelial cancer cells. , 2000, Cancer research.

[7]  Alfred Böcking,et al.  Diagnostic accuracy of effusion cytology , 1999, Diagnostic cytopathology.

[8]  R. Sarı,et al.  Correlation of serum levels of adenosine deaminase activity and its isoenzymes with disease activity in rheumatoid arthritis. , 2003, Clinical and experimental rheumatology.

[9]  B. Gupta,et al.  Sensitivity, Specificity, Negative and Positive Predictive Values of Adenosine Deaminase in Patients of Tubercular and Non-Tubercular Serosal Effusion in India , 2010, Journal of clinical medicine research.

[10]  C. Gakis.  Adenosine deaminase (ADA) isoenzymes ADA1 and ADA2: diagnostic and biological role. , 1996, The European respiratory journal.

[11]  M. Daidone,et al.  Purine salvage enzyme activities in normal and neoplastic human tissues. , 1990, Cancer biochemistry biophysics.

[12]  R. Kryscio,et al.  Ovarian volume related to age. , 2000, Gynecologic oncology.

[13]  M. Aghaei,et al.  Diagnostic value of adenosine deaminase activity in benign and malignant breast tumors. , 2010, Archives of medical research.

[14]  M. Kurdoğlu,et al.  Pelvic-peritoneal tuberculosis simulating peritoneal carcinomatosis: high clinical suspicion and a minimally invasive procedure , 2009, Archives of Gynecology and Obstetrics.

[15]  M. Arrese,et al.  Value of Adenosine Deaminase (ADA) in Ascitic Fluid for the Diagnosis of Tuberculous Peritonitis: A Meta-analysis , 2006, Journal of clinical gastroenterology.

[16]  Ashok Agarwal,et al.  Potential Markers for Detection and Monitoring of Ovarian Cancer , 2011, Journal of oncology.

[17]  Huanzhong Shi,et al.  Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: a meta-analysis. , 2008, Respiratory Medicine.

[18]  N. Kurata.  [Adenosine deaminase]. , 2020, Nihon rinsho. Japanese journal of clinical medicine.

[19]  F. Karami-Tehrani,et al.  Adenosine deaminase activity in the serum and malignant tumors of breast cancer: the assessment of isoenzyme ADA1 and ADA2 activities. , 2005, Clinical biochemistry.

[20]  Shunji Suzuki,et al.  Serum adenosine deaminase activity in women with hyperemesis gravidarum. , 2002, Clinica chimica acta; international journal of clinical chemistry.

[21]  A. Sevinç,et al.  Non-Hodgkin lymphoma with high adenosine deaminase levels mimicking peritoneal tuberculosis: An unusual presentation , 2006, Leukemia & lymphoma.

[22]  H. Akgül,et al.  Activities of adenosine deaminase and 5′-nucleotidase in cancerous and noncancerous human colorectal tissues , 2000, Medical oncology.

[23]  M. B. Amar,et al.  Peritoneal tuberculosis. , 2011, Clinics and research in hepatology and gastroenterology.

[24]  M. Hatzistilianou,et al.  Adenosine Deaminase Activity and Its Isoenzyme Pattern in Women with Recurrent Spontaneous Abortions , 2004, Gynecologic and Obstetric Investigation.

[25]  B. Zaric,et al.  Differential Diagnosis of Tuberculous and Malignant Pleural Effusions: What is the Role of Adenosine Deaminase? , 2008, Lung.