Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria.

[1]  N. Plesnila,et al.  Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. , 2008, Cell metabolism.

[2]  Matthew J. Rardin,et al.  Dual Specificity Phosphatases 18 and 21 Target to Opposing Sides of the Mitochondrial Inner Membrane , 2008, Journal of Biological Chemistry.

[3]  H. Kuhn,et al.  Role for glutathione peroxidase-4 in brain development and neuronal apoptosis: specific induction of enzyme expression in reactive astrocytes following brain injury. , 2007, Free radical biology & medicine.

[4]  A. Richardson,et al.  Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity , 2006, Journal of neuroscience research.

[5]  D. Green,et al.  Connected to Death: The (Unexpurgated) Mitochondrial Pathway of Apoptosis , 2005, Science.

[6]  Qing Zhao,et al.  Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors , 2005, Nature chemical biology.

[7]  D. Newmeyer,et al.  Mitochondrial Release of Pro-apoptotic Proteins , 2005, Journal of Biological Chemistry.

[8]  A. Girotti,et al.  Role of mitochondrial cardiolipin peroxidation in apoptotic photokilling of 5-aminolevulinate-treated tumor cells. , 2005, Archives of biochemistry and biophysics.

[9]  W. Bradley,et al.  Cytochrome c Association with the Inner Mitochondrial Membrane Is Impaired in the CNS of G93A-SOD1 Mice , 2005, The Journal of Neuroscience.

[10]  A. Richardson,et al.  Transgenic Mice Overexpressing Glutathione Peroxidase 4 Are Protected against Oxidative Stress-induced Apoptosis* , 2004, Journal of Biological Chemistry.

[11]  P. Tsao,et al.  Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease. , 2004, Blood.

[12]  M. MacDonald,et al.  Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release. , 2004, Human molecular genetics.

[13]  J. Andersen,et al.  Oxidative stress in neurodegeneration: cause or consequence? , 2004, Nature Reviews Neuroscience.

[14]  G. Paradies,et al.  Role of Reactive Oxygen Species and Cardiolipin in the Release of Cytochrome C from Mitochondria , 2022 .

[15]  P. Champion,et al.  Resonance Raman investigations of cytochrome c conformational change upon interaction with the membranes of intact and Ca2+-exposed mitochondria. , 2003, Biochemistry.

[16]  Jason G. Belter,et al.  The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. , 2003, Free radical biology & medicine.

[17]  H. Imai,et al.  Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. , 2003, Free radical biology & medicine.

[18]  Jake Jacobson,et al.  Intracellular distribution of the fluorescent dye nonyl acridine orange responds to the mitochondrial membrane potential: implications for assays of cardiolipin and mitochondrial mass , 2002, Journal of neurochemistry.

[19]  G. Pérez-Yarza,et al.  Implication of mitochondria-derived ROS and cardiolipin peroxidation in N-(4-hydroxyphenyl)retinamide-induced apoptosis , 2002, British Journal of Cancer.

[20]  Sten Orrenius,et al.  Cytochrome c release from mitochondria proceeds by a two-step process , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[21]  A. Girotti,et al.  Hyperresistance to cholesterol hydroperoxide-induced peroxidative injury and apoptotic death in a tumor cell line that overexpresses glutathione peroxidase isotype-4. , 2001, Free radical biology & medicine.

[22]  I. Fridovich,et al.  Subcellular Distribution of Superoxide Dismutases (SOD) in Rat Liver , 2001, The Journal of Biological Chemistry.

[23]  Freya Q. Schafer,et al.  Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy. , 2001, Free radical biology & medicine.

[24]  J C Reed,et al.  Mechanisms of apoptosis. , 2000, The American journal of pathology.

[25]  H. Imai,et al.  Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis. , 2000, The Biochemical journal.

[26]  R. Brigelius-Flohé,et al.  Overexpression of PHGPx inhibits hydroperoxide-induced oxidation, NFkappaB activation and apoptosis and affects oxLDL-mediated proliferation of rabbit aortic smooth muscle cells. , 2000, Atherosclerosis.

[27]  J. Janin,et al.  The Human nm23-H4 Gene Product Is a Mitochondrial Nucleoside Diphosphate Kinase* , 2000, The Journal of Biological Chemistry.

[28]  T. Sugawara,et al.  The Cytosolic Antioxidant Copper/Zinc-Superoxide Dismutase Prevents the Early Release of Mitochondrial Cytochrome c in Ischemic Brain after Transient Focal Cerebral Ischemia in Mice , 2000, The Journal of Neuroscience.

[29]  R. Brigelius-Flohé.  Tissue-specific functions of individual glutathione peroxidases. , 1999, Free radical biology & medicine.

[30]  H. Imai,et al.  Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Suppresses Apoptosis Mediated by a Mitochondrial Death Pathway* , 1999, The Journal of Biological Chemistry.

[31]  Stephan J. Sigrist,et al.  Oxygen Stress: A Regulator of Apoptosis in Yeast , 1999, The Journal of cell biology.

[32]  H. Imai,et al.  Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Plays a Major Role in Preventing Oxidative Injury to Cells* , 1999, The Journal of Biological Chemistry.

[33]  T. Jabs.  Reactive oxygen intermediates as mediators of programmed cell death in plants and animals. , 1999, Biochemical pharmacology.

[34]  D. Green.  Apoptotic Pathways The Roads to Ruin , 1998, Cell.

[35]  Mark P. Mattson,et al.  Prevention of Mitochondrial Injury by Manganese Superoxide Dismutase Reveals a Primary Mechanism for Alkaline-induced Cell Death* , 1998, The Journal of Biological Chemistry.

[36]  V. Skulachev.  Cytochrome c in the apoptotic and antioxidant cascades , 1998, FEBS letters.

[37]  A. Colell,et al.  Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species , 1997, The Journal of Biological Chemistry.

[38]  H. Imai,et al.  Overexpression of phospholipid hydroperoxide glutathione peroxidase suppressed cell death due to oxidative damage in rat basophile leukemia cells (RBL-2H3). , 1996, Biochemical and biophysical research communications.

[39]  H. Manev,et al.  Removal of serum from primary cultures of cerebellar granule neurons induces oxidative stress and DNA fragmentation: Protection with antioxidants and glutamate receptor antagonists , 1996, Journal of neuroscience research.

[40]  Q. Sun,et al.  Expression of human phospholipid hydroperoxide glutathione peroxidase gene for protection of host cells from lipid hydroperoxide-mediated injury. , 1996, Biochemical and biophysical research communications.

[41]  F. Antunes,et al.  PHGPx and phospholipase A2/GPx: comparative importance on the reduction of hydroperoxides in rat liver mitochondria. , 1995, Free radical biology & medicine.

[42]  J. Tschopp,et al.  Bcl‐2 protects from oxidative damage and apoptotic cell death without interfering with activation of NF‐κB by TNF , 1994, FEBS letters.

[43]  H. Blöcker,et al.  Phospholipid-hydroperoxide glutathione peroxidase. Genomic DNA, cDNA, and deduced amino acid sequence. , 1994, The Journal of biological chemistry.

[44]  J. Coyle,et al.  Oxidative stress, glutamate, and neurodegenerative disorders. , 1993, Science.

[45]  C. Cotman,et al.  Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[46]  M. Ratinaud,et al.  10N-nonyl acridine orange interacts with cardiolipin and allows the quantification of this phospholipid in isolated mitochondria. , 1992, European journal of biochemistry.

[47]  C. V. Smith,et al.  Evidence for participation of lipid peroxidation and iron in diquat-induced hepatic necrosis in vivo. , 1987, Molecular pharmacology.

[48]  Y. Fujiki,et al.  Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum , 1982, The Journal of cell biology.

[49]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[50]  C. Schnaitman,et al.  ENZYMATIC PROPERTIES OF THE INNER AND OUTER MEMBRANES OF RAT LIVER MITOCHONDRIA , 1968, The Journal of cell biology.

[51]  W. J. Dyer,et al.  A rapid method of total lipid extraction and purification. , 1959, Canadian journal of biochemistry and physiology.

[52]  E. Cadenas,et al.  One-electron transfer reactions of diquat radical to different reduction intermediates of oxygen. Formation of hydroxyl radical and electronically excited states. , 1988, Free radical biology & medicine.

[53]  H. Nissen,et al.  Analysis of phospholipids in human semen by high-performance liquid chromatography. , 1983, Journal of chromatography.