Contact-free monitoring of circulation and perfusion dynamics based on the analysis of thermal imagery.

Acute circulatory disorders are commonly associated with systemic inflammatory response (SIRS) and sepsis. During sepsis, microcirculatory perfusion is compromised leading to tissue hypoperfusion and potentially to multiple organ dysfunction. In the present study, acute lung injury (ALI), one of the major causes leading to SIRS and sepsis, was experimentally induced in six female pigs. To investigate the progress of body temperature distribution, measurements with a long-wave infrared camera were carried out. Temperature centralization was evidenced during ALI owing to impairments of peripheral perfusion. In addition, statistical analysis demonstrated strong correlations between (a) standard deviation of the skin temperature distribution (SD) and shock index (SI) (p<0.0005), (b) SD and mean arterial pressure (MAP) (p<0.0005), (c) ΔT/Δx and SI (p<0.0005), as well as between (d) ΔT/Δx and MAP (p<0.0005). For clarification purposes, ΔT/Δx is a parameter implemented to quantify the spatial temperature gradient. This pioneering study created promising results. It demonstrated the capacity of infrared thermography as well as of the indexes, SD and ΔT/Δx, to detect impairments in both circulation and tissue perfusion.

[1]  B. Markovitz,et al.  Is Shock Index Associated With Outcome in Children With Sepsis/Septic Shock?* , 2013, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

[2]  Steffen Leonhardt,et al.  Infrared thermography for detailed registration of thermoregulation in premature infants , 2013, Journal of perinatal medicine.

[3]  Nathan Shapiro,et al.  Shock Index and Early Recognition of Sepsis in the Emergency Department: Pilot Study , 2013, The western journal of emergency medicine.

[4]  S. Leonhardt,et al.  Analysis of regional compliance in a porcine model of acute lung injury , 2012, Respiratory Physiology & Neurobiology.

[5]  Jamie Perin,et al.  Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000 , 2012, The Lancet.

[6]  A. Marra,et al.  Decreasing Mortality in Severe Sepsis and Septic Shock Patients by Implementing a Sepsis Bundle in a Hospital Setting , 2011, PloS one.

[7]  Abbas K. Abbas,et al.  Neonatal non-contact respiratory monitoring based on real-time infrared thermography , 2011, Biomedical engineering online.

[8]  Gregory F. Lewis,et al.  A novel method for extracting respiration rate and relative tidal volume from infrared thermography. , 2011, Psychophysiology.

[9]  Arthur S Slutsky,et al.  Ventilator-induced lung injury and sepsis: two sides of the same coin? , 2011, Minerva anestesiologica.

[10]  Bob D Guenther,et al.  Thermoregulation and Thermography in Neonatal Physiology and Disease , 2011, Biological research for nursing.

[11]  R. Daniels.  Surviving the first hours in sepsis: getting the basics right (an intensivist's perspective). , 2011, The Journal of antimicrobial chemotherapy.

[12]  T. O'Shea,et al.  Heart rate characteristics: physiomarkers for detection of late-onset neonatal sepsis. , 2010, Clinics in perinatology.

[13]  G. Wishart,et al.  The accuracy of digital infrared imaging for breast cancer detection in women undergoing breast biopsy. , 2010, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[14]  G Machin,et al.  New standards for devices used for the measurement of human body temperature , 2010, Journal of medical engineering & technology.

[15]  P. Tsao,et al.  Neonatal sepsis: a 6-year analysis in a neonatal care unit in Taiwan. , 2009, Pediatrics and neonatology.

[16]  M. Levy,et al.  Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 , 2007, Intensive Care Medicine.

[17]  Marc Garbey,et al.  Contact-Free Measurement of Cardiac Pulse Based on the Analysis of Thermal Imagery , 2007, IEEE Transactions on Biomedical Engineering.

[18]  R. Dellinger,et al.  Hemodynamic optimization of sepsis-induced tissue hypoperfusion , 2006, Critical care.

[19]  P. Carmeliet,et al.  Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality , 2006, The Journal of experimental medicine.

[20]  K. Wood,et al.  Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock* , 2006, Critical care medicine.

[21]  C. Sprung,et al.  Sepsis in European intensive care units: Results of the SOAP study* , 2006, Critical care medicine.

[22]  S. Cousens,et al.  4 million neonatal deaths: When? Where? Why? , 2005, The Lancet.

[23]  R. Bellomo,et al.  Vital organ blood flow during hyperdynamic sepsis. , 2003, Chest.

[24]  Mitchell M. Levy,et al.  2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference , 2003, Intensive Care Medicine.

[25]  E. Ivers,et al.  Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock , 2001 .

[26]  G. Clermont,et al.  Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care , 2001, Critical care medicine.

[27]  M. Ragaller,et al.  Monitoring of organ dysfunction in sepsis/systemic inflammatory response syndrome: novel strategies. , 2001, Journal of the American Society of Nephrology : JASN.

[28]  F. Stüber.  Effects of genomic polymorphisms on the course of sepsis: is there a concept for gene therapy? , 2001, Journal of the American Society of Nephrology : JASN.

[29]  M. Odeh.  Sepsis, septicaemia, sepsis syndrome, and septic shock: the correct definition and use. , 1996, Postgraduate medical journal.

[30]  J. Edwards,et al.  Shock index: a re-evaluation in acute circulatory failure. , 1992, Resuscitation.

[31]  L. Rowell.  Human Circulation: Regulation During Physical Stress , 1986 .

[32]  K. Messmer.  Traumatic shock in polytrauma: Circulatory parameters, biochemistry, and resuscitation , 1983, World Journal of Surgery.

[33]  T. Love,et al.  THERMOGRAPHY AS AN INDICATOR OF BLOOD PERFUSION , 1980, Annals of the New York Academy of Sciences.

[34]  A. Merla,et al.  Functional Infrared Imaging in Medicine: A Quantitative Diagnostic Approach , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[35]  K. Messmer,et al.  Sepsis and Nutritional Blood Flow , 1994 .

[36]  N. Otsu.  A Threshold Selection Method from Gray-Level Histograms , 1979, IEEE Trans. Syst. Man Cybern..

[37]  T. Chau,et al.  Journal of Neuroengineering and Rehabilitation Open Access Infrared Thermography as an Access Pathway for Individuals with Severe Motor Impairments , 2022 .