Alveolar rhabdomyosarcoma associated with disseminated intravascular coagulation and a unique factor VIII antigen.

Disseminated intravascular coagulation (DIC) has been described in association with many tumors. We describe a patient with alveolar rhabdomyosarcoma in whom DIC developed with the initiation of chemotherapy. The patient achieved complete remission of his tumor for 14 months. An unusual factor VIII antigen was identified on crossed immunoelectrophoresis that was present at initial diagnosis, disappeared with remission, and returned with relapse of the tumor.

[1]  J. Rodés,et al.  Increased factor VIII complex and defective ristocetin-induced platelet aggregation in liver disease. , 1977, Thrombosis research.

[2]  A. Eldor,et al.  Alveolar rhabdomyosarcoma presenting as subacute intravascular coagulation. , 1977, Journal of clinical pathology.

[3]  K. Denson.  The ratio of factor VIII-related antigen and factor VIII biological activity as an index of hypercoagulability and intravascular clotting. , 1977, Thrombosis research.

[4]  J. Simeon,et al.  Electrophoretic heterogeneity of normal factor VIII/Von Willebrand protein, and abnormal electrophoretic mobility in patients with Von Willebrand's disease. , 1976, The Journal of laboratory and clinical medicine.

[5]  D. Harkness,et al.  In vivo and in vitro effects of thrombin and plasmin on human factor VIII (ahf) , 1976, American journal of hematology.

[6]  T. Edgington,et al.  Factor-VIII-related antigen: multiple molecular forms in human plasma. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[7]  H. Weiss,et al.  Quantitative assay of a plasma factor deficient in von Willebrand's disease that is necessary for platelet aggregation. Relationship to factor VIII procoagulant activity and antigen content. , 1973, The Journal of clinical investigation.

[8]  Ruymann Fb,et al.  Therapeutic approaches to factor X deficiency with emphasis on the use of a new clotting-factor concentrate (Konyne). , 1971 .

[9]  C. Merskey,et al.  The Defibrination Syndrome: Clinical Features and Laboratory Diagnosis , 1967, British journal of haematology.

[10]  I. Ingram,et al.  The determination of plasma fibrinogen by the clot-weight method. , 1952, The Biochemical journal.