Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma.
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[1] B. Ferruà,et al. Regulation of interleukin 2 synthesis by cAMP in human T cells. , 1987, Journal of immunology.
[2] R. Coffman,et al. Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures , 1988, The Journal of experimental medicine.
[3] G. Kammer. The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response. , 1988, Immunology today.
[4] M. Gougerot-Pocidalo,et al. Differential regulation of IL 6, IL 1 A, IL 1β and TNFα production in LPS-stimulated human monocytes: Role of cyclic AMP , 1990 .
[5] N. Turner,et al. Characterization of guinea-pig eosinophil phosphodiesterase activity. Assessment of its involvement in regulating superoxide generation. , 1991, Biochemical pharmacology.
[6] C. Deutsch,et al. Cyclic AMP directly inhibits IL-2 receptor expression in human T cells: expression of both p55 and p75 subunits is affected. , 1991, Journal of immunology.
[7] S. Døskeland,et al. Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3',5'-cyclic adenosine monophosphate on cell replication in human T lymphocytes. , 1992, The Journal of biological chemistry.
[8] S. Durham,et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. , 1992, The New England journal of medicine.
[9] T. Torphy,et al. Beta-adrenoceptors, cAMP and airway smooth muscle relaxation: challenges to the dogma. , 1994, Trends in pharmacological sciences.
[10] L. Lichtenstein,et al. IL-13 expression at the sites of allergen challenge in patients with asthma. , 1995, Journal of immunology.
[11] J. Pène,et al. Role of cyclic nucleotides and nitric oxide in blood mononuclear cell IgE production stimulated by IL-4. , 1995, Cytokine.
[12] J. Nadel,et al. Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. , 1995, Cellular signalling.
[13] V. Lagente,et al. Selective inhibition of phosphodiesterase type IV suppresses the chemotactic responsiveness of rat eosinophils in vitro. , 1996, European journal of pharmacology.
[14] P. Foster,et al. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model , 1996, The Journal of experimental medicine.
[15] R. Looney,et al. Regulation of IgE and cytokine production by cAMP: implications for extrinsic asthma. , 1996, Clinical immunology and immunopathology.
[16] J. Beleta,et al. Inhibition of eotaxin‐mediated human eosinophil activation and migration by the selective cyclic nucleotide phosphodiesterase type 4 inhibitor rolipram , 1997, British journal of pharmacology.
[17] S. Christensen,et al. Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig. , 1998, The Journal of pharmacology and experimental therapeutics.
[18] D B Corry,et al. Requirement for IL-13 independently of IL-4 in experimental asthma. , 1998, Science.
[19] D D Donaldson,et al. Interleukin-13: central mediator of allergic asthma , 1998 .
[20] M. Houslay,et al. The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions. , 1998, Advances in pharmacology.
[21] T. Torphy. Phosphodiesterase isozymes: molecular targets for novel antiasthma agents. , 1998, American journal of respiratory and critical care medicine.
[22] S. Christensen,et al. SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions. , 1998, The Journal of pharmacology and experimental therapeutics.
[23] W. P. Kuo,et al. Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[24] I. C. Almeida,et al. Differential inhibitory mechanism of cyclic AMP on TNF‐α and IL‐12 synthesis by macrophages exposed to microbial stimuli , 1999, British journal of pharmacology.
[25] R. Wange,et al. Specific CD3 epsilon association of a phosphodiesterase 4B isoform determines its selective tyrosine phosphorylation after CD3 ligation. , 1999, Journal of immunology.
[26] S. Jin,et al. Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[27] E. Gelfand,et al. Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice. , 2000, American journal of respiratory cell and molecular biology.
[28] M. Jordana,et al. IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[29] R. Pauwels,et al. Specific Migratory Dendritic Cells Rapidly Transport Antigen from the Airways to the Thoracic Lymph Nodes , 2001, The Journal of experimental medicine.
[30] D. Umetsu,et al. Critical Role for IL-13 in the Development of Allergen-Induced Airway Hyperreactivity1 , 2001, The Journal of Immunology.
[31] S. Yamamoto,et al. Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs. , 2001, Journal of Pharmacology and Experimental Therapeutics.
[32] M. Mäkelä,et al. Tumor Necrosis Factor- α Negatively Regulates Airway Hyperresponsiveness through γδ T Cells , 2001 .
[33] S. Jin,et al. Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. , 2002, The Journal of clinical investigation.
[34] D. Corry,et al. Interleukins-4, -5, and -13: emerging therapeutic targets in allergic disease. , 2002, Pharmacology & therapeutics.
[35] S. Jin,et al. Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[36] J. Madrenas,et al. Regulation of T-Cell Activation by Phosphodiesterase 4B2 Requires Its Dynamic Redistribution during Immunological Synapse Formation , 2003, Molecular and Cellular Biology.
[37] D. Umetsu,et al. PDE4D plays a critical role in the control of airway smooth muscle contraction , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[38] Tomas Mustelin,et al. Positive and negative regulation of T-cell activation through kinases and phosphatases. , 2003, The Biochemical journal.
[39] S. Mackenzie,et al. The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma , 2004, Respiratory research.
[40] M. Pruniaux,et al. Nonredundant Function of Phosphodiesterases 4D and 4B in Neutrophil Recruitment to the Site of Inflammation1 , 2004, The Journal of Immunology.
[41] M. Zaccolo,et al. TCR- and CD28-Mediated Recruitment of Phosphodiesterase 4 to Lipid Rafts Potentiates TCR Signaling1 , 2004, The Journal of Immunology.
[42] S. Orkin,et al. A Critical Role for Eosinophils in Allergic Airways Remodeling , 2004, Science.
[43] Lauren Cohn,et al. Asthma: mechanisms of disease persistence and progression. , 2004, Annual review of immunology.
[44] S. Jin,et al. Specific Role of Phosphodiesterase 4B in Lipopolysaccharide-Induced Signaling in Mouse Macrophages 1 , 2005, The Journal of Immunology.
[45] B. Lipworth. Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease , 2005, The Lancet.
[46] S. Reiken,et al. Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias , 2005, Cell.
[47] M. Tsai,et al. Mast Cell-Associated TNF Promotes Dendritic Cell Migration1 , 2006, The Journal of Immunology.
[48] M. Conti,et al. Differential Expression and Function of Phosphodiesterase 4 (PDE4) Subtypes in Human Primary CD4+ T Cells: Predominant Role of PDE4D1 , 2007, The Journal of Immunology.
[49] E. Génin,et al. Evidence for a Locus in 1p31 Region Specifically Linked to the Co-Morbidity of Asthma and Allergic Rhinitis in the EGEA Study , 2007, Human Heredity.
[50] S. Galli,et al. Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice. , 2007, The Journal of allergy and clinical immunology.
[51] D. Spina,et al. PDE4 inhibitors: current status , 2008, British journal of pharmacology.
[52] F. Martinez,et al. Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials , 2009, The Lancet.
[53] R. Tsujita,et al. Discovery of selective PDE4B inhibitors. , 2009, Bioorganic & medicinal chemistry letters.