CALCIUM: A KEY PLAYER IN RAPID COLD-HARDENING

![Figure][1] Some insects are capable of dramatically adjusting their cold tolerance over an extremely short period of time. Early studies in fruit flies showed that a brief pre-treatment of an hour or two to a sub-lethal temperature allowed these individuals to survive what would have

[1]  D. Denlinger,et al.  Rapid cold-hardening in larvae of the Antarctic midge Belgica antarctica: cellular cold-sensing and a role for calcium. , 2008, American journal of physiology. Regulatory, integrative and comparative physiology.