Trypanosoma brucei Glycogen Synthase Kinase-3, A Target for Anti-Trypanosomal Drug Development: A Public-Private Partnership to Identify Novel Leads
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Tod P. Holler | L. Maes | Richard O. Oduor | W. V. Van Voorhis | K. Ojo | D. Pryde | James E. J. Mills | Gareth P. Williams | T. Parkinson | Louis Maes | Francois Bertelli | T. Holler | F. Bertelli | Wesley C. Van Voorhis | Kayode K. Ojo | James Mills | David C. Pryde | Tanya Parkinson
[1] M. Roussel,et al. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. , 1998, Genes & development.
[2] Simone Sciabola,et al. High-Throughput Biochemical Kinase Selectivity Assays: Panel Development and Screening Applications , 2009, Journal of biomolecular screening.
[3] P. Kennedy. The continuing problem of human African trypanosomiasis (sleeping sickness) , 2008, Annals of neurology.
[4] Thomas D. Y. Chung,et al. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays , 1999, Journal of biomolecular screening.
[5] M. Dumas,et al. Treatment of human African trypanosomiasis. , 1983, Bulletin of the World Health Organization.
[6] M. Dumas,et al. Treatment perspectives for human African trypanosomiasis , 2003, Fundamental & clinical pharmacology.
[7] Jeffrey Jie-Lou Liao,et al. Molecular recognition of protein kinase binding pockets for design of potent and selective kinase inhibitors. , 2007, Journal of medicinal chemistry.
[8] Hilmar Weinmann,et al. Drug discovery process for kinase inhibitors. , 2005, Chembiochem : a European journal of chemical biology.
[9] Dustin J Maly,et al. Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors , 2010, Nature Structural &Molecular Biology.
[10] Kozo Nakamura,et al. GSK-3β Controls Osteogenesis through Regulating Runx2 Activity , 2007, PloS one.
[11] P. Greengard,et al. Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease , 2001, The Journal of Biological Chemistry.
[12] Kirk W. Johnson,et al. Modulation of muscle insulin resistance by selective inhibition of GSK-3 in Zucker diabetic fatty rats. , 2003, American journal of physiology. Endocrinology and metabolism.
[13] S. Knapp,et al. Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors. , 2003, Journal of molecular biology.
[14] C. Decaestecker,et al. In vitro antiprotozoal, antimicrobial and antitumor activity of Pavetta crassipes K. Schum leaf extracts. , 2010, Journal of ethnopharmacology.
[15] T. Hunter,et al. The Protein Kinase Complement of the Human Genome , 2002, Science.
[16] M. Barrett,et al. Chemotherapy of human African trypanosomiasis. , 2002, Current pharmaceutical design.
[17] B. Doble,et al. GSK-3: tricks of the trade for a multi-tasking kinase , 2003, Journal of Cell Science.
[18] Ana Martínez,et al. Glycogen synthase kinase 3 (GSK‐3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation , 2002, Medicinal research reviews.
[19] J. Woodgett,et al. Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation , 2000, Nature.
[20] L. Maes,et al. Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'. , 2006, Journal of ethnopharmacology.
[21] Hilmar Weinmann Dr. and,et al. Editorial: Drug Discovery Process for Kinease Inhibitors , 2005 .
[22] Els Torreele,et al. Drug development for neglected diseases: a deficient market and a public-health policy failure , 2002, The Lancet.
[23] Hilmar Weinmann,et al. Editorial: Drug Discovery Process for Kinease Inhibitors , 2005 .
[24] Timothy N C Wells,et al. Glycogen Synthase Kinase 3 Is a Potential Drug Target for African Trypanosomiasis Therapy , 2008, Antimicrobial Agents and Chemotherapy.
[25] R. Nusse,et al. β-catenin: a key mediator of Wnt signaling , 1998 .
[26] H. Eldar-Finkelman,et al. Long-Term Treatment with Novel Glycogen Synthase Kinase-3 Inhibitor Improves Glucose Homeostasis in ob/ob Mice: Molecular Characterization in Liver and Muscle , 2006, Journal of Pharmacology and Experimental Therapeutics.
[27] R. Jope,et al. The glamour and gloom of glycogen synthase kinase-3. , 2004, Trends in biochemical sciences.
[28] P. Simarro,et al. Eliminating Human African Trypanosomiasis: Where Do We Stand and What Comes Next> , 2008, PLoS medicine.
[29] C. Naula,et al. Protein kinases as drug targets in trypanosomes and Leishmania. , 2005, Biochimica et biophysica acta.
[30] R. Moon,et al. The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. , 1996, Genes & development.
[31] C. Doerig. Protein kinases as targets for anti-parasitic chemotherapy. , 2004, Biochimica et Biophysica Acta.
[32] G L Snyder,et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? , 2001, The Journal of biological chemistry.
[33] M. Barrett,et al. Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis , 2009, Brain : a journal of neurology.