TTK inhibition increases cisplatin sensitivity in high-grade serous ovarian carcinoma through the mTOR/autophagy pathway

[1]  Haibo Zhang,et al.  TTK inhibitor promotes radiosensitivity of liver cancer cells through p21. , 2021, Biochemical and biophysical research communications.

[2]  D. Matei,et al.  Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. , 2021, Journal of the National Comprehensive Cancer Network : JNCCN.

[3]  Hongxia Huang,et al.  TTK regulates proliferation and apoptosis of gastric cancer cells through the Akt‐mTOR pathway , 2020, FEBS open bio.

[4]  H. Briem,et al.  Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase. , 2020, Journal of medicinal chemistry.

[5]  A. Rogalska,et al.  Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer , 2020, Journal of Hematology & Oncology.

[6]  J. Hung,et al.  Upregulation of Thr/Tyr kinase Increases the Cancer Progression by Neurotensin and Dihydropyrimidinase-Like 3 in Lung Cancer , 2020, International journal of molecular sciences.

[7]  S. Merajver,et al.  TTK inhibition radiosensitizes basal-like breast cancer through impaired homologous recombination. , 2020, The Journal of clinical investigation.

[8]  D. Lin,et al.  Silencing TTK expression inhibits the proliferation and progression of prostate cancer. , 2019, Experimental cell research.

[9]  Xiaofei Chen,et al.  Mitotic checkpoint kinase Mps1/TTK predicts prognosis of colon cancer patients and regulates tumor proliferation and differentiation via PKCα/ERK1/2 and PI3K/Akt pathway , 2019, Medical Oncology.

[10]  B. Kong,et al.  PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma , 2019, Cell Death & Disease.

[11]  Yu Liu,et al.  Down-regulation of OGT promotes cisplatin resistance by inducing autophagy in ovarian cancer , 2018, Theranostics.

[12]  W. Huh,et al.  Rad52 phosphorylation by Ipl1 and Mps1 contributes to Mps1 kinetochore localization and spindle assembly checkpoint regulation , 2017, Proceedings of the National Academy of Sciences.

[13]  C. Sunkel,et al.  Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing , 2017, eLife.

[14]  C. Der,et al.  Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability , 2017, PloS one.

[15]  A. Faisal,et al.  Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy , 2017, British Journal of Cancer.

[16]  T. Mak,et al.  Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer , 2017, Proceedings of the National Academy of Sciences.

[17]  Xiao-fang Sheng,et al.  HLF/miR-132/TTK axis regulates cell proliferation, metastasis and radiosensitivity of glioma cells. , 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[18]  E. White,et al.  Recent insights into the function of autophagy in cancer , 2016, Genes & development.

[19]  R. V. van Montfort,et al.  Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach. , 2016, Journal of medicinal chemistry.

[20]  M. Bookman Optimal primary therapy of ovarian cancer. , 2016, Annals of oncology : official journal of the European Society for Medical Oncology.

[21]  J. Ellenberg,et al.  ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores , 2016, The Journal of cell biology.

[22]  P. Lienau,et al.  Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity , 2016, Molecular Cancer Therapeutics.

[23]  Taejeong Bae,et al.  Restoration of paclitaxel resistance by CDK1 intervention in drug-resistant ovarian cancer. , 2015, Carcinogenesis.

[24]  Jian Huang,et al.  TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells , 2015, Oncotarget.

[25]  R. Medema,et al.  Molecular basis underlying resistance to Mps1/TTK inhibitors , 2015, Oncogene.

[26]  X. Yao,et al.  Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment , 2015, Proceedings of the National Academy of Sciences.

[27]  R. Medema,et al.  Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model. , 2015, Annals of oncology : official journal of the European Society for Medical Oncology.

[28]  Yusuke Nakamura,et al.  A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity. , 2015, Bioorganic & medicinal chemistry.

[29]  Narendra Kumar Patel,et al.  The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents. , 2015, Journal of medicinal chemistry.

[30]  Yusuke Nakamura,et al.  Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity. , 2015, Journal of medicinal chemistry.

[31]  K. Camphausen,et al.  Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins , 2014, Molecular Cancer Research.

[32]  U. Gruneberg,et al.  PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing , 2014, The Journal of cell biology.

[33]  Dan-dan Wang,et al.  Expression and Function Analysis of Mitotic Checkpoint Genes Identifies TTK as a Potential Therapeutic Target for Human Hepatocellular Carcinoma , 2014, PloS one.

[34]  Gen Sheng Wu,et al.  Role of Autophagy in Cisplatin Resistance in Ovarian Cancer Cells* , 2014, The Journal of Biological Chemistry.

[35]  L. Galluzzi,et al.  Characterization of novel MPS1 inhibitors with preclinical anticancer activity , 2013, Cell Death and Differentiation.

[36]  Stephen S. Taylor,et al.  The Spindle Assembly Checkpoint , 2012, Current Biology.

[37]  Zhihao Zhuang Faculty Opinions recommendation of Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy. , 2012 .

[38]  Xuedong Liu,et al.  The MPS1 family of protein kinases. , 2012, Annual review of biochemistry.

[39]  E. White Deconvoluting the context-dependent role for autophagy in cancer , 2012, Nature Reviews Cancer.

[40]  C. Her,et al.  MutS homologue hMSH5: role in cisplatin-induced DNA damage response , 2012, Molecular Cancer.

[41]  Aaron Rogers,et al.  Characterization of the Cellular and Antitumor Effects of MPI-0479605, a Small-Molecule Inhibitor of the Mitotic Kinase Mps1 , 2011, Molecular Cancer Therapeutics.

[42]  Kenneth P. Nephew,et al.  Rethinking ovarian cancer: recommendations for improving outcomes , 2011, Nature Reviews Cancer.

[43]  Riccardo Colombo,et al.  Synthesis and SAR of new pyrazolo[4,3-h]quinazoline-3-carboxamide derivatives as potent and selective MPS1 kinase inhibitors. , 2011, Bioorganic & medicinal chemistry letters.

[44]  E. Gabrielson,et al.  High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells , 2011, Proceedings of the National Academy of Sciences.

[45]  Antonella Isacchi,et al.  Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. , 2010, Cancer research.

[46]  Taebo Sim,et al.  Small Molecule Kinase Inhibitors Provide Insight into Mps1 Cell Cycle Function , 2010, Nature chemical biology.

[47]  Kai Stoeber,et al.  Cdc7 Kinase Is a Predictor of Survival and a Novel Therapeutic Target in Epithelial Ovarian Carcinoma , 2009, Clinical Cancer Research.

[48]  Chao Zhang,et al.  Chemical Genetics Reveals a Role for Mps1 Kinase in Kinetochore Attachment during Mitosis , 2005, Current Biology.

[49]  Eric L. Weiss,et al.  The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint , 1996, The Journal of cell biology.

[50]  N. Jiang,et al.  Protein kinase TTK promotes proliferation and migration and mediates epithelial-mesenchymal transition in human bladder cancer cells. , 2018, International journal of clinical and experimental pathology.

[51]  Geert J P L Kops,et al.  Joined at the hip: kinetochores, microtubules, and spindle assembly checkpoint signaling. , 2015, Trends in cell biology.

[52]  D. Rubinsztein,et al.  Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies , 2009, Cell Death and Differentiation.