Near-infrared optical sensors based on single-walled carbon nanotubes

Molecular detection using near-infrared light between 0.9 and 1.3 eV has important biomedical applications because of greater tissue penetration and reduced auto-fluorescent background in thick tissue or whole-blood media. Carbon nanotubes have a tunable near-infrared emission that responds to changes in the local dielectric function but remains stable to permanent photobleaching. In this work, we report the synthesis and successful testing of solution-phase, near-infrared sensors, with β-D-glucose sensing as a model system, using single-walled carbon nanotubes that modulate their emission in response to the adsorption of specific biomolecules. New types of non-covalent functionalization using electron-withdrawing molecules are shown to provide sites for transferring electrons in and out of the nanotube. We also show two distinct mechanisms of signal transduction—fluorescence quenching and charge transfer. The results demonstrate new opportunities for nanoparticle optical sensors that operate in strongly absorbing media of relevance to medicine or biology.

[1]  D. Delpy,et al.  Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation. , 1988, Biochimica et biophysica acta.

[2]  L. Peter,et al.  Dynamic aspects of semiconductor photoelectrochemistry , 1990 .

[3]  L. B. Ebert Science of fullerenes and carbon nanotubes , 1996 .

[4]  L. Gorton,et al.  Prussian-Blue-based amperometric biosensors in flow-injection analysis. , 1996, Talanta.

[5]  M. Dresselhaus,et al.  Physical properties of carbon nanotubes , 1998 .

[6]  A Heller,et al.  Implanted electrochemical glucose sensors for the management of diabetes. , 1999, Annual review of biomedical engineering.

[7]  Lin Xia,et al.  Structure and Function of Ferricyanide in the Formation of Chromate Conversion Coatings on Aluminum Aircraft Alloy , 1999 .

[8]  L. Gorton,et al.  Amperometric biosensor for glutamate using prussian blue-based "artificial peroxidase" as a transducer for hydrogen peroxide. , 2000, Analytical chemistry.

[9]  Lo Gorton,et al.  Prussian Blue- and lactate oxidase-based amperometric biosensor for lactic acid , 2001 .

[10]  O. Rolinski,et al.  Near-infrared fluorescence lifetime assay for serum glucose based on allophycocyanin-labeled concanavalin A. , 2001, Analytical biochemistry.

[11]  D Compagnone,et al.  Construction and analytical characterization of Prussian-Blue-based carbon paste electrodes and their assembly as oxidase enzyme sensors. , 2001, Analytical chemistry.

[12]  R. Smalley,et al.  Functionalization of carbon nanotubes by electrochemical reduction of aryl diazonium salts: a bucky paper electrode. , 2001, Journal of the American Chemical Society.

[13]  R. A. Ware,et al.  A novel reagentless sensing system for measuring glucose based on the galactose/glucose-binding protein. , 2001, Analytical biochemistry.

[14]  J. Hafner,et al.  Chirality-dependent G-band Raman intensity of carbon nanotubes , 2001 .

[15]  Characterization of glucose oxidase immobilization onto mica carrier by atomic force microscopy and kinetic studies. , 2002, Biomolecular engineering.

[16]  R. Smalley,et al.  Structure-Assigned Optical Spectra of Single-Walled Carbon Nanotubes , 2002, Science.

[17]  A biosensor based on transient photoeffects at a silicon electrode , 2002 .

[18]  J. Tour,et al.  Covalent chemistry of single-wall carbon nanotubes , 2002 .

[19]  M. Dresselhaus,et al.  Double resonance raman spectrain disordered graphite and singlewall carbon nanotubes , 2002 .

[20]  M. Dresselhaus,et al.  Probing phonon dispersion relations of graphite by double resonance Raman scattering. , 2001, Physical review letters.

[21]  Ray H. Baughman,et al.  Direct electron transfer of glucose oxidase on carbon nanotubes , 2002 .

[22]  V. C. Moore,et al.  Band Gap Fluorescence from Individual Single-Walled Carbon Nanotubes , 2002, Science.

[23]  Koji Nakano,et al.  Self-assembling monolayer formation of glucose oxidase covalently attached on 11-aminoundecanethiol monolayers on gold. , 2003, Chemical communications.

[24]  J. Frangioni In vivo near-infrared fluorescence imaging. , 2003, Current opinion in chemical biology.

[25]  M. Shim,et al.  Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[26]  V. C. Moore,et al.  Individually suspended single-walled carbon nanotubes in various surfactants , 2003 .

[27]  M. Zheng,et al.  DNA-assisted dispersion and separation of carbon nanotubes , 2003, Nature materials.

[28]  Interfacial Dissociation and Unfolding of Glucose Oxidase , 2003 .

[29]  V. C. Moore,et al.  The role of surfactant adsorption during ultrasonication in the dispersion of single-walled carbon nanotubes. , 2003, Journal of nanoscience and nanotechnology.

[30]  M. Dresselhaus,et al.  Structure-Based Carbon Nanotube Sorting by Sequence-Dependent DNA Assembly , 2003, Science.

[31]  L. Novotný,et al.  Simultaneous Fluorescence and Raman Scattering from Single Carbon Nanotubes , 2003, Science.

[32]  L. Tilley,et al.  Characterization of a series of far-red-absorbing thiobarbituric acid oxonol derivatives as fluorescent probes for biological applications. , 2003, Analytical biochemistry.

[33]  R. Smalley,et al.  Electronic Structure Control of Single-Walled Carbon Nanotube Functionalization , 2003, Science.

[34]  Carter Kittrell,et al.  Reversible, Band-Gap-Selective Protonation of Single-Walled Carbon Nanotubes in Solution , 2003 .

[35]  Vishal Saxena,et al.  Degradation kinetics of indocyanine green in aqueous solution. , 2003, Journal of pharmaceutical sciences.

[36]  K. Okazaki,et al.  Absolute potential of the Fermi level of isolated single-walled carbon nanotubes , 2003 .

[37]  T. Mihaljevic,et al.  Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping , 2004, Nature Biotechnology.

[38]  M. Fuhrer,et al.  Extraordinary Mobility in Semiconducting Carbon Nanotubes , 2004 .

[39]  M. Strano,et al.  Resonant Raman excitation profiles of individually dispersed single walled carbon nanotubes in solution , 2004 .