The novel inhibitor of the heterotrimeric G-protein complex, BIM-46187, elicits anti-hyperalgesic properties and synergizes with morphine.

[1]  J. Gutkind,et al.  G-protein-coupled receptors and cancer , 2007, Nature Reviews Cancer.

[2]  D. Zaharevitz,et al.  Anticancer Activity of BIM-46174, a New Inhibitor of the Heterotrimeric Gα/Gβγ Protein Complex , 2006 .

[3]  Alan V. Smrcka,et al.  Differential Targeting of Gßγ-Subunit Signaling with Small Molecules , 2006, Science.

[4]  T. Meert,et al.  A preclinical comparison between different opioids: antinociceptive versus adverse effects , 2005, Pharmacology Biochemistry and Behavior.

[5]  S. Powers,et al.  G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers , 2004, Oncogene.

[6]  Clifford J. Woolf,et al.  Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management , 2004, Annals of Internal Medicine.

[7]  A. Ahmadiani,et al.  Involvement of Interleukin‐1β in Systemic Morphine Effects on Paw Oedema in a Mouse Model of Acute Inflammation , 2004, Scandinavian journal of immunology.

[8]  Anita Preininger,et al.  Insights into G protein structure, function, and regulation. , 2003, Endocrine reviews.

[9]  R. Amann,et al.  Effects of Morphine on Oedema and Tissue Concentration of Nerve Growth Factor in Experimental Inflammation of the Rat Paw , 2002, Pharmacology.

[10]  V. Neugebauer,et al.  Peripheral metabotropic glutamate receptors as drug targets for pain relief , 2002, Expert opinion on therapeutic targets.

[11]  N. Dhanasekaran,et al.  Transforming G proteins , 2001, Oncogene.

[12]  Ronald J. Tallarida,et al.  Drug Synergism and Dose-Effect Data Analysis , 2000 .

[13]  G. Guilbaud,et al.  Effects of intraplantar morphine on paw edema and pain-related behaviour in a rat model of repeated acute inflammation , 1999, PAIN.

[14]  R. Gross,et al.  Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids , 1999 .

[15]  M. Connor,et al.  OPIOID RECEPTOR SIGNALLING MECHANISMS , 1999, Clinical and experimental pharmacology & physiology.

[16]  M. Freissmuth,et al.  G proteins as drug targets , 1999, Cellular and Molecular Life Sciences CMLS.

[17]  A. Latronico,et al.  Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors. , 1998, The Journal of clinical endocrinology and metabolism.

[18]  S. Ho,et al.  Intrathecal ketamine reduces morphine requirements in patients with terminal cancer pain , 1996, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[19]  F. De Conno,et al.  Antidepressants in Cancer Pain , 1991, Journal of Palliative Care.

[20]  R. Dubner,et al.  Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia , 1990, Pain.

[21]  D. Carr,et al.  Neuropeptides and pain. , 1990, Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression.

[22]  Gary J. Bennett,et al.  A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man , 1988, Pain.

[23]  K. Gyires,et al.  Morphine inhibits the carrageenan‐induced oedema and the chemoluminescence of leucocytes stimulated by zymosan , 1985, The Journal of pharmacy and pharmacology.

[24]  R. Lo,et al.  A method for measurement of analgesic activity on inflamed tissue. , 1957 .

[25]  Dianqing Wu,et al.  Differential targeting of Gbetagamma-subunit signaling with small molecules. , 2006, Science.

[26]  D. Zaharevitz,et al.  Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric Galpha/Gbetagamma protein complex. , 2006, Cancer research.

[27]  H. Zeilhofer Synaptic modulation in pain pathways. , 2005, Reviews of physiology, biochemistry and pharmacology.

[28]  R. Gross,et al.  Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[29]  J. Pin,et al.  Pharmacology and functions of metabotropic glutamate receptors. , 1997, Annual review of pharmacology and toxicology.

[30]  A Cowan,et al.  Statistical analysis of drug-drug and site-site interactions with isobolograms. , 1989, Life sciences.

[31]  L. O. Randall,et al.  A method for measurement of analgesic activity on inflamed tissue. , 1957, Archives internationales de pharmacodynamie et de therapie.