Relationship between level of circulating endothelial progenitor cells and severity of ischemic chronic heart failure with preserved left ventricular ejection fraction

sclerosis in patients cohort with angiographically determined coronary artery disease. The most important independent predictors of lower circulating levels of EPC with the phenotype CD14 + CD309 + Tie2 + are CHF (OR = 1.45, 95% CI = 1.12-1.88; P = 0.004), type 2 diabetes (OR = 1.21, 95% CI = 1.10-1.40; P = 0.008), NT-pro-BNP> 154 fmol / mL (OR = 1.13, 95% CI = 1.04-1.18; P = 0.003), hyperlipidemia (OR = 1.12, 95% CI = 1.05-1.23; P = 0.005), as well as the presence of three or more traditional cardiovascular risk factors (OR = 1.31, 95% CI = 1.12-1.49; P = 0.008). Conclusion: The negative impact of cardiovascular risk factors in respect of the manifestation of ischemic CHF may be mediated by non-hematopoietic deficiency of circulating EPC, whose mobilization from peripheral tissues is reduced in the early stages of myocardial dysfunction.