Relationship between level of circulating endothelial progenitor cells and severity of ischemic chronic heart failure with preserved left ventricular ejection fraction
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sclerosis in patients cohort with angiographically determined coronary artery disease. The most important independent predictors of lower circulating levels of EPC with the phenotype CD14 + CD309 + Tie2 + are CHF (OR = 1.45, 95% CI = 1.12-1.88; P = 0.004), type 2 diabetes (OR = 1.21, 95% CI = 1.10-1.40; P = 0.008), NT-pro-BNP> 154 fmol / mL (OR = 1.13, 95% CI = 1.04-1.18; P = 0.003), hyperlipidemia (OR = 1.12, 95% CI = 1.05-1.23; P = 0.005), as well as the presence of three or more traditional cardiovascular risk factors (OR = 1.31, 95% CI = 1.12-1.49; P = 0.008). Conclusion: The negative impact of cardiovascular risk factors in respect of the manifestation of ischemic CHF may be mediated by non-hematopoietic deficiency of circulating EPC, whose mobilization from peripheral tissues is reduced in the early stages of myocardial dysfunction.
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