Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attack (CROMIS-2): a multicentre observational cohort study

M. Power | D. Werring | H. Jäger | T. Yousry | A. Charidimou | J. Staals | S. Maguire | J. Bamford | Mark White | K. Harkness | K. Muir | A. Parry-Jones | R. Al‐Shahi Salman | H. Houlden | M. Bhargava | A. Hedstrom | K. Chatterjee | G. Ambler | E. Richards | M. Doherty | A. Bhalla | A. Rudd | J. Corrigan | C. Eglinton | D. Mangion | N. Sprigg | G. Banerjee | G. Lip | E. Mckenzie | R. Veltkamp | J. Birns | A. Steele | M. Mamun | D. Manawadu | C. Roffe | M. Randall | H. Kingwell | M. Brown | E. Flossmann | D. Hargroves | S. Andole | D. Cohen | E. Warburton | A. Mistri | H. Emsley | C. Schofield | Kari Saastamoinen | K. Dani | L. Shaw | J. Sword | A. Mohd Nor | F. Harrington | Matthew Smith | K. Mahawish | B. Esisi | C. Cullen | Arumug Nallasivam | C. Price | L. Sekaran | Harald Proschel | Prabel Datta | A. Manoj | M. Burn | C. Patterson | E. Giallombardo | N. Smyth | S. Mansoor | Ijaz Anwar | S. Ispoglou | D. Chadha | Sanjeevikumar Meenakishundaram | Jon F Scott | Vinodh Krishnamurthy | Prasanna Aghoram | M. Mccormick | P. O'mahony | M. Cooper | Lillian Choy | P. Wilkinson | S. Leach | I. Burger | G. Gunathilagan | P. Guyler | Michelle L. Davis | Kath Pasco | R. Luder | M. Sajid | J. Okwera | T. England | Janet Putterill | D. Vahidassr | C. Shakeshaft | P. Owusu-Agyei | B. Gregary | K. Dunne | B. Hairsine | R. Erande | O. Redjep | P. Murphy | A. Misra | E. Amis | S. Mashate | R. Gascoyne | D. Bruce | E. Brown | G. Rogers | C. Watchurst | D. Walstow | I. Wynter | L. Makawa | D. Waugh | A. Needle | V. Riddell | A. Buck | N. Temple | A. Hardwick | N. Persad | G. Courtauld | A. Bowring | G. Fletcher | P. López | H. Maguire | D. Button | B. Madigan | K. Storey | T. Thompson | T. Marsden | S. Tysoe | F. Watson | E. Young | B. Bhaskaran | P. Fitzell | Z. Mellor | B. Kumar | S. Crawford | P. Farren | A. Banaras | J. Aeron-Thomas | Nicola C. Day | S. Subramonian | C. Holmes | D. Cotterill | R. Evans | M. Carpenter | S. Kausar | Garryck Tan | Mia Porteous | Hannah Cohen | V. Nguyen | S. Punekar | Frances Justin | M. Tate | Mushiya Mpelembue | Jane Perez | D. Epstein | Sagal Kullane | N. Bhupathiraju | T. Ingram | Madeleine McKee | P. Anderton | Pankaj Sharma | Rachel Marsh | John Aeron-Thomas | C. Edwards | Anthea Parry | Jagdish Sharma | Lynne Connell | Amelia Daniel | Belinda Wroath | L. Burgess | Simon Sharpe | D. Wilson | Banher Sandhu | Michael Haley | M. Mpelembue | J. O’Connell | N. Butler | Chukwuka Orefo | Cassilda Peixoto | Evelyne Burssens | David C. Wilson | Shagufta Khan | R. Gallifent | G. Tallón | John Prasanna Elaine Peter Sreeman Ijaz John Azra Aian Aeron-Thomas Aghoram Amis Anderton Andole An | Aian Barry | Ruth Bellfied | Aienne Benford | Aian Blight | Kerry Bunworth | Mauian Burton | C. Douglas | Abduelbaset Elmarimi | Senussi Hussein | L. Iveson | V. Johnson | Karen Kee | M. Keeling | Agnieszka Kieliszkowska | Sana Leason | Clare McGolick | Habib Rehman | Anew Smith | G. Storey | Jennifer Teke | Anouk van der Kwaak | Sarah Wilson-Owen | Martin M. Brown | Amelia Daniel | J. Teke | Mark White | Collette Edwards | Sissi Ispoglou | David Wilson | P. Lopez | Rachel Gallifent | J. Perez | A. Daniel | David Wilson | Duncan Wilson | L. Connell | M. McKee | A. Blight | A. Kieliszkowska | S. Leason

[1]  G. Lip,et al.  Major bleeding and intracranial hemorrhage risk prediction in patients with atrial fibrillation: Attention to modifiable bleeding risk factors or use of a bleeding risk stratification score? A nationwide cohort study. , 2018, International journal of cardiology.

[2]  V. Mok,et al.  Brain microbleeds, anticoagulation, and hemorrhage risk , 2017, Neurology.

[3]  G. Breithardt,et al.  Outcome of Patients Receiving Thrombolytic Therapy While on Rivaroxaban for Nonvalvular Atrial Fibrillation (from Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation). , 2017, The American journal of cardiology.

[4]  A. Charidimou,et al.  Cerebral microbleeds and white matter hyperintensities in cardioembolic stroke patients due to atrial fibrillation: single-centre longitudinal study , 2016, Journal of the Neurological Sciences.

[5]  D. Werring,et al.  Recurrent stroke risk and cerebral microbleed burden in ischemic stroke and TIA , 2016, Neurology.

[6]  D. Werring,et al.  The Clinical Relevance of Microbleeds in Stroke study (CROMIS-2): rationale, design, and methods , 2015, International journal of stroke : official journal of the International Stroke Society.

[7]  Jean-Claude Baron,et al.  Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions. , 2015, Brain : a journal of neurology.

[8]  Manesh R. Patel,et al.  Intracranial Hemorrhage Among Patients With Atrial Fibrillation Anticoagulated With Warfarin or Rivaroxaban: The Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation , 2014, Stroke.

[9]  M. L. Lauzon,et al.  Susceptibility-Weighted Imaging is More Reliable Than T2*-Weighted Gradient-Recalled Echo MRI for Detecting Microbleeds , 2013, Stroke.

[10]  R. Giugliano,et al.  Current and new oral antithrombotics in non-valvular atrial fibrillation: a network meta-analysis of 79 808 patients , 2013, Heart.

[11]  Nick C Fox,et al.  Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration , 2013, The Lancet Neurology.

[12]  Y. D. Kim,et al.  The frequency of cerebral microbleeds increases with CHADS2 scores in stroke patients with non‐valvular atrial fibrillation , 2013, European journal of neurology.

[13]  K. Butcher,et al.  Poor Prognosis in Warfarin-Associated Intracranial Hemorrhage Despite Anticoagulation Reversal , 2012, Stroke.

[14]  Mårten Rosenqvist,et al.  Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study. , 2012, European heart journal.

[15]  O. Benavente,et al.  Cerebral Microbleeds: Histopathological Correlation of Neuroimaging , 2011, Cerebrovascular Diseases.

[16]  D. Singer,et al.  A new risk scheme to predict warfarin-associated hemorrhage: The ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study. , 2011, Journal of the American College of Cardiology.

[17]  Gregory Y H Lip,et al.  A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. , 2010, Chest.

[18]  M. van Buchem,et al.  Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy , 2010, Neurology.

[19]  D Bergqvist,et al.  Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients , 2010, Journal of thrombosis and haemostasis : JTH.

[20]  D. Werring,et al.  The Microbleed Anatomical Rating Scale (MARS) , 2009, Neurology.

[21]  Steven Warach,et al.  Cerebral Microbleeds : A Field Guide to their Detection and Interpretation , 2012 .

[22]  Joanna M Wardlaw,et al.  Improving Interrater Agreement About Brain Microbleeds: Development of the Brain Observer MicroBleed Scale (BOMBS) , 2009, Stroke.

[23]  E. Steyerberg Clinical Prediction Models , 2008, Statistics for Biology and Health.

[24]  P. Kirchhof,et al.  Detection of asymptomatic cerebral microbleeds: a comparative study at 1.5 and 3.0 T. , 2008, Academic radiology.

[25]  M. Aguilar,et al.  Meta-analysis: Antithrombotic Therapy to Prevent Stroke in Patients Who Have Nonvalvular Atrial Fibrillation , 2007, Annals of Internal Medicine.

[26]  M. Rich,et al.  Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF). , 2006, American heart journal.

[27]  S. Schulman,et al.  Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non‐surgical patients , 2005, Journal of thrombosis and haemostasis : JTH.

[28]  G. Albers,et al.  Comparing the guidelines: anticoagulation therapy to optimize stroke prevention in patients with atrial fibrillation. , 2004, Journal of the American College of Cardiology.

[29]  P. Scheltens,et al.  A New Rating Scale for Age-Related White Matter Changes Applicable to MRI and CT , 2001, Stroke.

[30]  P Kapeller,et al.  Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. , 1999, AJNR. American journal of neuroradiology.

[31]  H. Boshuizen,et al.  Multiple imputation of missing blood pressure covariates in survival analysis. , 1999, Statistics in medicine.

[32]  R. Tibshirani The lasso method for variable selection in the Cox model. , 1997, Statistics in medicine.

[33]  A. Alavi,et al.  MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. , 1987, AJR. American journal of roentgenology.

[34]  K. Rexrode,et al.  Prospective Study of Fasting Blood Glucose and Intracerebral Hemorrhagic Risk , 2018, Stroke.

[35]  M. Dichgans,et al.  Superficial siderosis is a warning sign for future intracranial hemorrhage , 2012, Journal of Neurology.

[36]  R. Abbate,et al.  Risk of bleeding in very old atrial fibrillation patients on warfarin: relationship with ageing and CHADS2 score. , 2007, Thrombosis research.