Care and Outcomes of Asian-American Acute Myocardial Infarction Patients: Findings From the American Heart Association Get With The Guidelines-Coronary Artery Disease Program

Background— Asian-Americans represent an important United States minority population, yet there are limited data regarding the clinical care and outcomes of Asian-Americans following acute myocardial infarction (AMI). Using data from the American Heart Association Get With The Guidelines-Coronary Artery Disease (GWTG-CAD) program, we compared use of and trends in evidence-based care AMI processes and outcome in Asian-American versus white patients. Methods and Results— We analyzed 107 403 AMI patients (4412 Asian-Americans, 4.1%) from 382 United States centers participating in the Get With The Guidelines-Coronary Artery Disease program between 2003 and 2008. Use of 6 AMI performance measures, composite “defect-free” care (proportion receiving all eligible performance measures), door-to-balloon time, and in-hospital mortality were examined. Trends in care over this time period were explored. Compared with whites, Asian-American AMI patients were significantly older, more likely to be covered by Medicaid and recruited in the west region, and had a higher prevalence of diabetes, hypertension, heart failure, and smoking. In-hospital unadjusted mortality was higher among Asian-American patients. Overall, Asian-Americans were comparable with whites regarding the baseline quality of care, except that Asian-Americans were less likely to get smoking cessation counseling (65.6% versus 81.5%). Asian-American AMI patients experienced improvement in the 6 individual measures (P⩽0.048), defect-free care (P<0.001), and door-to-balloon time (P<0.001). The improvement rates were similar for both Asian-Americans and whites. Compared with whites, the adjusted in-hospital mortality rate was higher for Asian-Americans (adjusted relative risk: 1.16; 95% confidence interval: 1.00–1.35; P=0.04). Conclusions— Evidence-based care for AMI processes improved significantly over the period of 2003 to 2008 for Asian-American and white patients in the Get With The Guidelines-Coronary Artery Disease program. Differences in care between Asian-Americans and whites, when present, were reduced over time.

[1]  Antonio Pflüger,et al.  Executive Summary. , 2012, Journal of the ICRU.

[2]  Diversity in cardiovascular outcomes among Chinese and South Asian patients. , 2010, Circulation.

[3]  C. Ghosh A national health agenda for Asian Americans and Pacific Islanders. , 2010, JAMA.

[4]  Deepak L. Bhatt,et al.  Comparative determinants of 4-year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis. , 2010, JAMA.

[5]  T. Assimes,et al.  Call to action: cardiovascular disease in Asian Americans: a science advisory from the American Heart Association. , 2010, Circulation.

[6]  Deepak L. Bhatt,et al.  Advancing the care of cardiac patients using registry data: going where randomized clinical trials dare not. , 2010, JAMA.

[7]  Sidney C. Smith,et al.  Racial and Ethnic Differences in the Treatment of Acute Myocardial Infarction: Findings From the Get With The Guidelines-Coronary Artery Disease Program , 2010, Circulation.

[8]  C. Cannon,et al.  Are quality improvements associated with the Get With the Guidelines-Coronary Artery Disease (GWTG-CAD) program sustained over time? A longitudinal comparison of GWTG-CAD hospitals versus non-GWTG-CAD hospitals. , 2010, American heart journal.

[9]  J. Ornato,et al.  2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST‐Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update) , 2009, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[10]  Elizabeth DeLong,et al.  ACC/AHA classification of care metrics: performance measures and quality metrics: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. , 2008, Journal of the American College of Cardiology.

[11]  L. Haw,et al.  RACIAL VARIATION IN THE USE OF CORONARY-REVASCULARIZATION PROCEDURES , 2008 .

[12]  H. Krumholz,et al.  ACC/AHA 2008 performance measures for adults with ST-elevation and non-ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures (Writing Committee to develop performance measures for ST-elevation and non-ST-eleva , 2008, Circulation.

[13]  Sidney C. Smith,et al.  Improved treatment of hospitalized coronary artery disease patients with the get with the guidelines program. , 2007, Critical pathways in cardiology.

[14]  Deepak L. Bhatt,et al.  One-year cardiovascular event rates in outpatients with atherothrombosis. , 2007, JAMA.

[15]  E. Huang,et al.  Cardiovascular health disparities: a systematic review of health care interventions. , 2007, Medical care research and review : MCRR.

[16]  M. Budoff,et al.  Subclinical coronary atherosclerosis: racial profiling is necessary! , 2006, American heart journal.

[17]  A. Folsom,et al.  The effect of novel cardiovascular risk factors on the ethnic-specific odds for peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis (MESA). , 2006, Journal of the American College of Cardiology.

[18]  Elizabeth R DeLong,et al.  Association between hospital process performance and outcomes among patients with acute coronary syndromes. , 2006, JAMA.

[19]  Deepak L. Bhatt,et al.  International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. , 2006, JAMA.

[20]  H. Krumholz,et al.  ACC/AHA clinical performance measures for adults with ST-elevation and non-ST-elevation myocardial infarction. Commentary , 2006 .

[21]  Jane A. Linderbaum,et al.  ACC/AHA clinical performance measures for adults with ST-elevation and non-ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures (Writing Committee to Develop Performance Measures on ST-Elevation and Non-ST-El , 2006, Circulation.

[22]  G. Friedman,et al.  Risk of Hemorrhagic Stroke in Asian American Ethnic Groups , 2005, Neuroepidemiology.

[23]  E. Benjamin,et al.  Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: executive summary. , 2005, Circulation.

[24]  S. Daniels,et al.  Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Obesity, Metabolic Syndrome, and Hypertension Writing Group. , 2005, Circulation.

[25]  W. Gibler,et al.  Racial Variations in Treatment and Outcomes of Black and White Patients With High-Risk Non–ST-Elevation Acute Coronary Syndromes: Insights From CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines?) , 2005, Circulation.

[26]  E. Benjamin,et al.  Discovering the Full Spectrum of Cardiovascular Disease: Minority Health Summit 2003: Report of the Outcomes Writing Group , 2005, Circulation.

[27]  Deepak L. Bhatt,et al.  Utilization of early invasive management strategies for high-risk patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE Quality Improvement Initiative. , 2005, JAMA.

[28]  N. Kressin,et al.  Racial differences in cardiac catheterization as a function of patients' beliefs. , 2004, American journal of public health.

[29]  Harlan M Krumholz,et al.  Racial and ethnic differences in time to acute reperfusion therapy for patients hospitalized with myocardial infarction. , 2004, JAMA.

[30]  S. Fortmann,et al.  Coronary heart disease mortality for six ethnic groups in California, 1990-2000. , 2004, Annals of epidemiology.

[31]  R. Gliklich,et al.  Get with the guidelines for cardiovascular secondary prevention: pilot results. , 2004, Archives of internal medicine.

[32]  G. Zou,et al.  A modified poisson regression approach to prospective studies with binary data. , 2004, American journal of epidemiology.

[33]  U. C. Bureau Statistical Abstract of the United States , 2004 .

[34]  R. Gliklich,et al.  Using "get with the guidelines" to improve cardiovascular secondary prevention. , 2003, Joint Commission journal on quality and safety.

[35]  P. Heidenreich,et al.  Racial Disparity in Cardiac Procedures and Mortality Among Long‐Term Survivors of Cardiac Arrest , 2003, Circulation.

[36]  E. Braunwald,et al.  Assessing the effect of publication of clinical guidelines on the management of unstable angina and non-ST elevation myocardial infarction in the TIMI III (1990-1993) and the GUARANTEE (1995-1996) Registries. , 2002, Critical pathways in cardiology.

[37]  Robert Parrish,et al.  Improving quality of care for acute myocardial infarction: The Guidelines Applied in Practice (GAP) Initiative. , 2002, JAMA.

[38]  N. Kressin,et al.  Racial Differences in Health-Related Beliefs, Attitudes, and Experiences of VA Cardiac Patients: Scale Development and Application , 2002, Medical care.

[39]  N. Kressin,et al.  Racial Differences in the Use of Invasive Cardiovascular Procedures: Review of the Literature and Prescription for Future Research , 2001, Annals of Internal Medicine.

[40]  B. Tilley,et al.  Use of odds ratio or relative risk to measure a treatment effect in clinical trials with multiple correlated binary outcomes: data from the NINDS t‐PA stroke trial , 2001, Statistics in medicine.

[41]  A. Gawlinski,et al.  Improved treatment of coronary heart disease by implementation of a Cardiac Hospitalization Atherosclerosis Management Program (CHAMP). , 2001, The American journal of cardiology.

[42]  K. Labresh,et al.  Get with the guidelines. , 2013, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[43]  W. Rogers,et al.  Management and outcomes for black patients with acute myocardial infarction in the reperfusion era , 1998 .

[44]  W. Rogers,et al.  Management and outcomes for black patients with acute myocardial infarction in the reperfusion era. National Registry of Myocardial Infarction 2 Investigators. , 1998, The American journal of cardiology.

[45]  R. Califf,et al.  Racial variation in the use of coronary-revascularization procedures. Are the differences real? Do they matter? , 1997, The New England journal of medicine.

[46]  E. Braunwald,et al.  Influence of race, sex, and age on management of unstable angina and non-Q-wave myocardial infarction: The TIMI III registry. , 1996 .

[47]  Moon S. Chen,et al.  A Debunking of the Myth of Healthy Asian Americans and Pacific Islanders , 1995, American journal of health promotion : AJHP.

[48]  J. Lin-Fu Asian and Pacific Islander Americans: An Overview of Demographic Characteristics and Health Care Issues. , 1993, Asian American and Pacific Islander journal of health.

[49]  S. Zeger,et al.  Longitudinal data analysis using generalized linear models , 1986 .