Indium Mediated Reduction of Nitro and Azide Groups in the Presence of HCl in Aqueous Media

Indium mediated reduction of azide and nitro groups in the presence of HCl (1.5 equiv based on indium) at room tempera- ture in aqueous THF successfully provided the corresponding amine in high to quantitative yields. Under the same reaction condi- tions, selective reduction of azide and nitro group in the presence of vinyl group could be accomplished.