Infiltration of the iris in chronic lymphatic leukaemia.

Case Report A man aged 59 was first seen in February, 1964, complaining of ankle swelling and shortness of breath on exertion. Examination.-There was a grossly enlarged liver and spleen, generalized lymphadenopathy, and mild congestive cardiac failure. Haematological investigation showed Hb 68 per cent., white blood count 102,000/cu. mm. (99 per cent. lymphocytes, 1 per cent. neutrophils), platelets 68,000/cu. mm. Diagnosis.-Chronic lymphatic leukaemia. Treatment.-Chlorambucil was given and the patient's general condition soon improved; after a month, although the haemoglobin remained at only 72 per cent., the total white cell count had fallen to 12,500/cu. mm. (87 per cent. lymphocytes). Progress.-During the next 2 years he remained well and the haemoglobin was maintained at approximately 80 per cent. although the white cell count varied considerably, ranging from 7,400/ cu. mm. (90 per cent. lymphocytes) to 109,000 (98 per cent. lymphocytes).