Chronic obstructive pulmonary disease • 3: Experimental animal models of pulmonary emphysema

The use of genetically manipulated mice together with traditional animal studies are steadily increasing our knowledge of the factors important in determining alveolar formation and destruction in emphysema. A review of the animal models used to study emphysema is presented.

[1]  G. Peces-Barba,et al.  Oral N-acetylcysteine attenuates elastase-induced pulmonary emphysema in rats. , 2004, Chest.

[2]  M. Hind,et al.  Pre- and postnatal lung development, maturation, and plasticity - Temporal/spatial expression of retinoid binding proteins and RAR isoforms in the postnatal lung , 2002 .

[3]  Tasuku Honjo,et al.  Fibulin-5/DANCE is essential for elastogenesis in vivo , 2002, Nature.

[4]  Xiang‐Dong Wang,et al.  Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response. , 2002, American journal of respiratory cell and molecular biology.

[5]  J. Keane,et al.  Severity of elastase-induced emphysema is decreased in tumor necrosis factor-alpha and interleukin-1beta receptor-deficient mice. , 2002, Laboratory investigation; a journal of technical methods and pathology.

[6]  J. Keane,et al.  Severity of Elastase-Induced Emphysema Is Decreased in Tumor Necrosis Factor-α and Interleukin-1β Receptor-Deficient Mice , 2002, Laboratory Investigation.

[7]  W. Hardie,et al.  Dose-dependent lung remodeling in transgenic mice expressing transforming growth factor-alpha. , 2001, American journal of physiology. Lung cellular and molecular physiology.

[8]  B. Trapnell,et al.  Alveolar macrophage deficiency in osteopetrotic mice deficient in macrophage colony-stimulating factor is spontaneously corrected with age and associated with matrix metalloproteinase expression and emphysema. , 2001, Blood.

[9]  T. Mak,et al.  Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3). , 2001, The Journal of clinical investigation.

[10]  S. Shapiro,et al.  End-stage chronic obstructive pulmonary disease: the cigarette is burned out but inflammation rages on. , 2001, American journal of respiratory and critical care medicine.

[11]  Simon C Watkins,et al.  Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor. , 2001, Developmental biology.

[12]  J. Whitsett,et al.  Surfactant Protein D Regulates NF-κB and Matrix Metalloproteinase Production in Alveolar Macrophages via Oxidant-Sensitive Pathways1 , 2001, The Journal of Immunology.

[13]  L. Lim,et al.  Transcription factors in mouse lung development and function. , 2001, American journal of physiology. Lung cellular and molecular physiology.

[14]  D. Warburton,et al.  Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis. , 2001, Developmental biology.

[15]  E. Haller,et al.  Identification of a Novel Lipopolysaccharide-Inducible Gene with Key Features of Both a Kinase Anchor Proteins and chs1/beige Proteins1 , 2001, The Journal of Immunology.

[16]  D A Lynch,et al.  Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. , 2001, American journal of respiratory and critical care medicine.

[17]  M. Fujita,et al.  Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension. , 2001, American journal of physiology. Lung cellular and molecular physiology.

[18]  R. Homer,et al.  Interferon γ Induction of Pulmonary Emphysema in the Adult Murine Lung , 2000, The Journal of experimental medicine.

[19]  P. Hirth,et al.  Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. , 2000, The Journal of clinical investigation.

[20]  P. Chambon,et al.  Retinoic acid receptor-beta: an endogenous inhibitor of the perinatal formation of pulmonary alveoli. , 2000, Physiological genomics.

[21]  B. Ma,et al.  Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. , 2000, The Journal of clinical investigation.

[22]  M. Keating,et al.  Impaired distal airway development in mice lacking elastin. , 2000, American journal of respiratory cell and molecular biology.

[23]  D. Keene,et al.  New Insights into the Assembly of Extracellular Microfibrils from the Analysis of the Fibrillin 1 Mutation in the Tight skin Mouse , 2000, The Journal of cell biology.

[24]  P. Chambon,et al.  Mice bearing deletions of retinoic acid receptors demonstrate reduced lung elastin and alveolar numbers. , 2000, American journal of respiratory cell and molecular biology.

[25]  D. Massaro,et al.  Retinoic acid treatment partially rescues failed septation in rats and in mice. , 2000, American journal of physiology. Lung cellular and molecular physiology.

[26]  S. Shapiro,et al.  Animal models for COPD. , 2000, Chest.

[27]  David Warburton,et al.  The molecular basis of lung morphogenesis , 2000, Mechanisms of Development.

[28]  R. Flavell,et al.  Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung. , 2000, American journal of respiratory cell and molecular biology.

[29]  N. Ishida,et al.  The prepro vasoactive intestinal contractor (VIC)/endothelin-2 gene (EDN2): structure, evolution, production, and embryonic expression. , 2000, Genomics.

[30]  B. Gilks,et al.  Acute cigarette smoke-induced connective tissue breakdown is mediated by neutrophils and prevented by alpha1-antitrypsin. , 2000, American journal of respiratory cell and molecular biology.

[31]  P. Calverley,et al.  The challenge of providing better care for patients with chronic obstructive pulmonary disease: the poor relation of airways obstruction? , 2000, Thorax.

[32]  R. Nagai,et al.  Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life. , 2000, American journal of respiratory cell and molecular biology.

[33]  J. Rossant,et al.  The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis. , 1999, Development.

[34]  Liping Huang,et al.  The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency , 1999, Nature Genetics.

[35]  G. Lungarella,et al.  Ultrastructure of lung elastin and collagen in mouse models of spontaneous emphysema. , 1999, Matrix biology : journal of the International Society for Matrix Biology.

[36]  J. Lasky,et al.  Emphysematous lesions, inflammation, and fibrosis in the lungs of transgenic mice overexpressing platelet-derived growth factor. , 1999, The American journal of pathology.

[37]  M Aguet,et al.  VEGF is required for growth and survival in neonatal mice. , 1999, Development.

[38]  C. Deng,et al.  FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. , 1998, Development.

[39]  R. Flavell,et al.  Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes. , 1997, The Journal of clinical investigation.

[40]  C. Betsholtz,et al.  Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development. , 1997, Development.

[41]  S. Shapiro,et al.  Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. , 1997, Science.

[42]  D. Massaro,et al.  Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats , 1997, Nature Medicine.

[43]  G. Turino,et al.  Further investigation of the use of intratracheally administered hyaluronic acid to ameliorate elastase-induced emphysema. , 1997, Experimental lung research.

[44]  S. Shapiro,et al.  Mighty mice: transgenic technology "knocks out" questions of matrix metalloproteinase function. , 1997, Matrix biology : journal of the International Society for Matrix Biology.

[45]  M. Lovett,et al.  Identification of the homologous beige and Chediak–Higashi syndrome genes , 1996, Nature.

[46]  C. Betsholtz,et al.  PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis , 1996, Cell.

[47]  S. Jimenez,et al.  A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation. , 1996, Genome research.

[48]  R. Evans,et al.  Compound mutants for retinoic acid receptor (RAR)β and RARα1 reveal developmental functions for multiple RARβ isoforms , 1996, Mechanisms of Development.

[49]  A. Churg,et al.  Mineral dusts cause elastin and collagen breakdown in the rat lung: a potential mechanism of dust-induced emphysema. , 1996, American journal of respiratory and critical care medicine.

[50]  G. Lungarella,et al.  A scanning electron microscopic investigation of genetic emphysema in tight-skin, pallid, and beige mice, three different C57 BL/6J mutants. , 1996, Laboratory investigation; a journal of technical methods and pathology.

[51]  R. Evans,et al.  Compound mutants for retinoic acid receptor (RAR) beta and RAR alpha 1 reveal developmental functions for multiple RAR beta isoforms. , 1996, Mechanisms of development.

[52]  J. Stone,et al.  Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity , 1995, Nature Medicine.

[53]  L. Fabbri,et al.  Effect of oxidant air pollutants on the respiratory system: insights from experimental animal research. , 1995, The European respiratory journal.

[54]  M. D. de Santi,et al.  Pallid mice with genetic emphysema. Neutrophil elastase burden and elastin loss occur without alteration in the bronchoalveolar lavage cell population. , 1995, Laboratory investigation; a journal of technical methods and pathology.

[55]  G. Turino,et al.  Modulation of airspace enlargement in elastase-induced emphysema by intratracheal instillment of hyaluronidase and hyaluronic acid. , 1995, Experimental lung research.

[56]  P. Lockhart,et al.  Mutations in the murine homologue of the Menkes gene in dappled and blotchy mice , 1994, Nature Genetics.

[57]  M. D. de Santi,et al.  The pallid mouse. A model of genetic alpha 1-antitrypsin deficiency. , 1993, Laboratory investigation; a journal of technical methods and pathology.

[58]  Y. Okada,et al.  Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema , 1992, Cell.

[59]  A. Harf,et al.  Prevention of leucocyte elastase-induced emphysema in mice by heparin fragments. , 1991, The European respiratory journal.

[60]  A. Churg,et al.  Cigarette smoke causes physiologic and morphologic changes of emphysema in the guinea pig. , 1990, The American review of respiratory disease.

[61]  G. Snider,et al.  Cadmium-chloride-induced air-space enlargement with interstitial pulmonary fibrosis is not associated with destruction of lung elastin. Implications for the pathogenesis of human emphysema. , 1988, The American review of respiratory disease.

[62]  M. Yamauchi,et al.  Structural crosslinking of lung connective tissue collagen in the blotchy mouse. , 1987, Experimental lung research.

[63]  G. Snider,et al.  Animal models of emphysema. , 1986, The American review of respiratory disease.

[64]  V. Ferrans,et al.  Hereditary emphysema in the tight-skin mouse. Evaluation of pathogenesis. , 2015, The American review of respiratory disease.

[65]  D. Niewoehner,et al.  Lung fibrosis and emphysema: divergent responses to a common injury? , 1982, Science.

[66]  R. Crystal,et al.  Elastin fragments attract macrophage precursors to diseased sites in pulmonary emphysema. , 1981, Science.

[67]  B. Starcher,et al.  The effect of lathyrogens on the evolution of elastase-induced emphysema. , 2015, The American review of respiratory disease.

[68]  R. Mecham,et al.  Chemotactic activity of elastin-derived peptides. , 1980, The Journal of clinical investigation.

[69]  C. Kuhn,et al.  Emphysema-like changes in the lungs of the blotchy mouse. , 1976, The American review of respiratory disease.

[70]  R. Senior,et al.  The induction of emphysema with elastase. II. Changes in connective tissue. , 1976, Laboratory investigation; a journal of technical methods and pathology.

[71]  H. O. Sweet,et al.  Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton. , 1976, The American journal of pathology.

[72]  J. Coalson,et al.  Pulmonary intravascular leukocyte sequestration. A potential mechanism of lung injury. , 1974, The American review of respiratory disease.

[73]  P. Gross,et al.  EXPERIMENTAL EMPHYSEMA: ITS PRODUCTION WITH PAPAIN IN NORMAL AND SILICOTIC RATS. , 1965, Archives of environmental health.