Inflammation and cancer: how hot is the link?

[1]  T. Chisesi,et al.  Tumor necrosis factor-alpha and B-cell growth factor induce leukemic hairy cells to proliferate in vitro. , 1991, Cancer detection and prevention.

[2]  J. Niloff,et al.  Tumor necrosis factor expression by human ovarian carcinoma in vivo. , 1991, Cancer research.

[3]  Philipp Lirk,et al.  Inducible nitric oxide synthase--time for reappraisal. , 2002, Current drug targets. Inflammation and allergy.

[4]  A. Cerami,et al.  Tumor necrosis factor alpha/cachectin is a growth factor for thymocytes. Synergistic interactions with other cytokines , 1988, The Journal of experimental medicine.

[5]  B. Aggarwal,et al.  Tumor necrosis factors: developments during the last decade. , 1996, European cytokine network.

[6]  A. Fauci,et al.  IL-6 and tumor necrosis factor-alpha. Autocrine and paracrine cytokines involved in B cell function. , 1991, Journal of immunology.

[7]  G. Booker,et al.  The subtle side to hypoxia inducible factor (HIFα) regulation , 2003 .

[8]  M. Turner,et al.  TUMOUR NECROSIS FACTOR AS AN AUTOCRINE TUMOUR GROWTH FACTOR FOR CHRONIC B-CELL MALIGNANCIES , 1988, The Lancet.

[9]  F. Balkwill,et al.  The chemokine network in cancer--much more than directing cell movement. , 2004, The International journal of developmental biology.

[10]  Raymond N DuBois,et al.  Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer. , 2003, Cancer research.

[11]  M. Okano,et al.  FROM BURKITT'S LYMPHOMA TO CHRONIC ACTIVE EPSTEIN-BARR VIRUS (EBV) INFECTION: An Expanding Spectrum of EBV-Associated Diseases , 2001, Pediatric hematology and oncology.

[12]  W. Isaacs,et al.  Modulation of CXCL14 (BRAK) expression in prostate cancer , 2005, The Prostate.

[13]  W. Jelkmann,et al.  Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1. , 1999, Blood.

[14]  L. Ährlund‐Richter,et al.  Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling. , 1999, Cancer research.

[15]  H. Hollema,et al.  Expression of cyclooxygenase-2 and inducible nitric oxide synthase in human ovarian tumors and tumor-associated macrophages. , 2001, Cancer research.

[16]  A. Ristimäki,et al.  Expression of cyclooxygenase-2 in human gastric carcinoma. , 1997, Cancer research.

[17]  G. Fantuzzi,et al.  IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[18]  C. Van Waes,et al.  Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma. , 2001, Cancer research.

[19]  B. Aggarwal,et al.  Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates. , 1998, The Journal of biological chemistry.

[20]  J. Schiller,et al.  Tumor necrosis factor, but not other hematopoietic growth factors, prolongs the survival of hairy cell leukemia cells. , 1992, Leukemia research.

[21]  J. Fitzpatrick,et al.  WHAT IS THE ROLE OF INFLAMMATION IN THE PATHOGENESIS OF PROSTATE CANCER? , 2007, BJU international.

[22]  W. Schmiegel,et al.  Inverse regulation of human ERBB2 and epidermal growth factor receptors by tumor necrosis factor alpha. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[23]  H. Fujiki,et al.  Helicobacter pylori membrane protein 1: a new carcinogenic factor of Helicobacter pylori. , 2001, Cancer research.

[24]  Yun-Jin Jung,et al.  IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[25]  G. Schettini,et al.  CXCR4 Activation Induces Epidermal Growth Factor Receptor Transactivation in an Ovarian Cancer Cell Line , 2004, Annals of the New York Academy of Sciences.

[26]  A. Arlt,et al.  Autocrine production of interleukin 1beta confers constitutive nuclear factor kappaB activity and chemoresistance in pancreatic carcinoma cell lines. , 2002, Cancer research.

[27]  B. Aggarwal,et al.  Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro. , 1985, Science.

[28]  M. Mai,et al.  Essential roles of tumor necrosis factor receptor p55 in liver metastasis of intrasplenic administration of colon 26 cells. , 2002, Cancer research.

[29]  N. Fausto,et al.  Impaired Preneoplastic Changes and Liver Tumor Formation in Tumor Necrosis Factor Receptor Type 1 Knockout Mice , 2000, The Journal of experimental medicine.

[30]  A. Komori,et al.  Tumor necrosis factor acts as a tumor promoter in BALB/3T3 cell transformation. , 1993, Cancer research.

[31]  T. Gilmore,et al.  Immortalized embryonic mouse fibroblasts lacking the RelA subunit of transcription factor NF-κB have a malignantly transformed phenotype , 2002, Oncogene.

[32]  C. Woodworth,et al.  Interleukin 1 alpha and tumor necrosis factor alpha stimulate autocrine amphiregulin expression and proliferation of human papillomavirus-immortalized and carcinoma-derived cervical epithelial cells. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[33]  Yudong D. He,et al.  Gene expression profiling predicts clinical outcome of breast cancer , 2002, Nature.

[34]  B. Aggarwal.  Tumor necrosis factors (TNF): A double-edged sword , 2000 .

[35]  R. Pathmanathan,et al.  Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma. , 2003, Cancer research.

[36]  R. Langer,et al.  Coexpression of cyclooxygenases (COX-1, COX-2) and vascular endothelial growth factors (VEGF-A, VEGF-C) in esophageal adenocarcinoma. , 2005, Cancer research.

[37]  L. Trentin,et al.  Expression and regulation of tumor necrosis factor, interleukin-2, and hematopoietic growth factor receptors in B-cell chronic lymphocytic leukemia. , 1994, Blood.

[38]  K. Schrör,et al.  Cyclooxygenase-2 expression in human esophageal carcinoma. , 1999, Cancer research.

[39]  G. Otsuka,et al.  Inhibition of nuclear factor-kappaB activation confers sensitivity to tumor necrosis factor-alpha by impairment of cell cycle progression in human glioma cells. , 1999, Cancer research.

[40]  Erwin G. Van Meir,et al.  Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system. , 1992, Cancer research.

[41]  L. Old,et al.  Human tumor necrosis factor produced by human B-cell lines: synergistic cytotoxic interaction with human interferon. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[42]  Andy J. Minn,et al.  Genes that mediate breast cancer metastasis to lung , 2005, Nature.

[43]  G. Otsuka,et al.  Inhibition of Nuclear Factor-κB Activation Confers Sensitivity to Tumor Necrosis Factor-α by Impairment of Cell Cycle Progression in Human Glioma Cells , 1999 .

[44]  L. Mahmoud,et al.  Tumor necrosis factor and human acute leukemia. , 1994, Leukemia & lymphoma.

[45]  B. Aggarwal,et al.  Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2. , 2002, Carcinogenesis.

[46]  H. Heimpel,et al.  Tumor necrosis factor induces proliferation of neoplastic B cells from chronic lymphocytic leukemia. , 1989, Blood.

[47]  Christine Dreyer,et al.  Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors , 1992, Cell.

[48]  Michael Karin,et al.  IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis , 2005, Cell.

[49]  J. Lehmann,et al.  Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[50]  P. Ratcliffe,et al.  HIF hydroxylation and cellular oxygen sensing , 2004, Biological chemistry.

[51]  F. Sinicrope,et al.  Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. , 2002, Cancer research.

[52]  A. Tzankov,et al.  Over‐expression of tumor necrosis factor‐alpha in bone marrow biopsies from patients with myelodysplastic syndromes: relationship to anemia and prognosis , 2005, European journal of haematology.

[53]  A. Richmond,et al.  Constitutive IkappaB kinase activity correlates with nuclear factor-kappaB activation in human melanoma cells. , 2001, Cancer research.

[54]  J. Masferrer,et al.  Direct evidence for a role of cyclooxygenase 2-derived prostaglandin E2 in human head and neck xenograft tumors. , 2002, Cancer research.

[55]  W. Digel,et al.  Receptors for tumor necrosis factor on neoplastic B cells from chronic lymphocytic leukemia are expressed in vitro but not in vivo. , 1990, Blood.

[56]  M. Kondo,et al.  Expression of cyclooxygenase-1 and -2 in human colorectal cancer. , 1995, Cancer research.

[57]  James B. Mitchell,et al.  Nuclear Factor-κB is an Important Modulator of the Altered Gene Expression Profile and Malignant Phenotype in Squamous Cell Carcinoma , 2004, Cancer Research.

[58]  P. Khavari,et al.  Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB , 1998 .

[59]  J. Puzas,et al.  Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB. , 2000, Cancer research.

[60]  L. Marnett,et al.  Oxyradicals and DNA damage. , 2000, Carcinogenesis.

[61]  J. Rüschoff,et al.  Enhancement of experimental metastasis by tumor necrosis factor , 1993, The Journal of experimental medicine.

[62]  E. Folch-Puy,et al.  Oxygen Free Radicals and the Systemic Inflammatory Response , 2004, IUBMB life.

[63]  M. Andreeff,et al.  Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells. , 2005, Blood.

[64]  H. Shepard,et al.  Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α , 1987, Nature.

[65]  B. Aggarwal,et al.  Nuclear factor-kappaB: a friend or a foe in cancer? , 2004, Biochemical pharmacology.

[66]  F. Balkwill,et al.  Epithelial cancer cell migration: a role for chemokine receptors? , 2001, Cancer research.

[67]  G. Booker,et al.  The subtle side to hypoxia inducible factor (HIFalpha) regulation. , 2003, European journal of biochemistry.

[68]  W. Schmiegel,et al.  Tumor necrosis factor alpha induces the expression of transforming growth factor alpha and the epidermal growth factor receptor in human pancreatic cancer cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[69]  M. Sherman,et al.  An association of cervical inflammation with high-grade cervical neoplasia in women infected with oncogenic human papillomavirus (HPV). , 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[70]  A. Castonguay,et al.  Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents. , 1998, Carcinogenesis.

[71]  B. Aggarwal,et al.  Nuclear factor-kappaB: a friend or a foe in cancer? , 2004, Biochemical pharmacology.

[72]  I. Fidler,et al.  Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells. , 2000, Cancer research.

[73]  M. Burdick,et al.  Cyclooxygenase-2-Dependent Expression of Angiogenic CXC Chemokines ENA-78/CXC Ligand (CXCL) 5 and Interleukin-8/CXCL8 in Human Non-Small Cell Lung Cancer , 2004, Cancer Research.

[74]  H. Ljunggren,et al.  Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappaB inhibition. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[75]  L. Ellis,et al.  Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways. , 2003, Cancer research.

[76]  H. Vinters,et al.  Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: evidence for the expression of a multitranscript family. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[77]  James B. Mitchell,et al.  Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma. , 2004, Cancer research.

[78]  Irina Kusmartseva,et al.  Constitutive production of proinflammatory cytokines RANTES, MIP-1beta and IL-18 characterizes LGL leukemia. , 2005, International journal of oncology.

[79]  B. Babior.  Phagocytes and oxidative stress. , 2000, The American journal of medicine.

[80]  K. O'Reilly,et al.  Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[81]  D. Alberts,et al.  Association between Cyclooxygenase expression and colorectal adenoma characteristics. , 2003, Cancer research.

[82]  Seaver,et al.  Nitric oxide as a secretory product of mammalian cells , 2004 .

[83]  P. Vogt,et al.  Tumor necrosis factor alpha and interleukin 1 alpha induce anchorage independence in v-jun transgenic murine cells. , 1993, Cancer research.

[84]  H. Mizoguchi,et al.  Stimulatory effect of tumor necrosis factor-alpha on the growth of CMK, a human megakaryoblastic leukemia cell line. , 1992, Leukemia research.

[85]  G. Casey,et al.  Breast Cancer Metastasis Suppressor 1 Inhibits Gene Expression by Targeting Nuclear Factor-κB Activity , 2005 .

[86]  D. Trisciuoglio,et al.  relA over-expression reduces tumorigenicity and activates apoptosis in human cancer cells , 2001, British Journal of Cancer.

[87]  T. Mcclanahan,et al.  Involvement of chemokine receptors in breast cancer metastasis , 2001, Nature.

[88]  Razelle Kurzrock,et al.  Autocrine interleukin-6 production in renal cell carcinoma: evidence for the involvement of p53. , 2002, Cancer research.

[89]  R. Millar,et al.  Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1. , 2002, Cancer research.

[90]  S. Tsuji,et al.  Effects of interferon-β on the cytokine production of astrocytes , 2005, Journal of Neuroimmunology.

[91]  T. Hagemann,et al.  Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK. , 2005, Journal of immunology.

[92]  M. Andreeff,et al.  Indole-3-carbinol suppresses NF-κB and IκBα kinase activation, causing inhibition of expression of NF-κB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells , 2005 .

[93]  R. Schmid,et al.  Nuclear factor-kappaB is constitutively active in C-cell carcinoma and required for RET-induced transformation. , 2001, Cancer research.

[94]  S. Yamamoto,et al.  Inhibition of two-stage skin carcinogenesis as well as complete skin carcinogenesis by oral administration of TMK688, a potent lipoxygenase inhibitor. , 1994, Carcinogenesis.

[95]  J. Shah,et al.  Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck. , 1999, Cancer research.

[96]  W. Jelkmann,et al.  Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1 , 1999 .

[97]  G. Wahl,et al.  p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy. , 2002, Cancer cell.

[98]  D. Ribatti,et al.  Effects of transforming growth factor-beta1 and tumour necrosis factor-alpha on cultured fibroblasts from skin fibroma as modulated by toremifene. , 2002, International journal of cancer.

[99]  S. Chanock,et al.  Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma. , 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[100]  L. Ben-Porat,et al.  Sun exposure and mortality from melanoma. , 2005, Journal of the National Cancer Institute.

[101]  B. Aggarwal,et al.  Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor necrosis factor (TNF) gene inhibit TNF production and block the TNF-dependent growth of human glioblastoma tumor cells. , 1996, Cancer research.

[102]  D. Ribatti,et al.  Effects of transforming growth factor‐β1 and tumour necrosis factor‐α on cultured fibroblasts from skin fibroma as modulated by toremifene , 2002 .

[103]  F. Balkwill.  Tumor necrosis factor or tumor promoting factor? , 2002, Cytokine & growth factor reviews.

[104]  R. Bast,et al.  Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression. , 1993, Cancer research.

[105]  D. Bostwick,et al.  Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. , 1999, Cancer research.

[106]  N. Nara,et al.  Growth potentiating activity of endogenous production of interleukin-1 and tumor necrosis factor alpha in blast cells of acute myeloblastic leukemia. , 1993, Experimental hematology.

[107]  A. Mantovani,et al.  Cancer: Inflammation by remote control , 2005, Nature.

[108]  R. DuBois,et al.  Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[109]  C. Bogdan.  Nitric oxide and the regulation of gene expression. , 2001, Trends in cell biology.

[110]  B. Aggarwal,et al.  Nuclear factor-kappaB: the enemy within. , 2004, Cancer cell.

[111]  K. Vousden,et al.  Role of NF-kappaB in p53-mediated programmed cell death. , 2000, Nature.

[112]  D. Beer,et al.  Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells. , 2000, Cancer research.

[113]  B. Aggarwal,et al.  Cigarette smoke condensate activates nuclear transcription factor-κB through phosphorylation and degradation of IκBα: correlation with induction of cyclooxygenase-2 , 2002 .

[114]  B. Wong,et al.  Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke. , 2005, Carcinogenesis.

[115]  F. Lanza,et al.  Evidence for a role of TNF-related apoptosis-inducing ligand (TRAIL) in the anemia of myelodysplastic syndromes. , 2005, The American journal of pathology.

[116]  B. Aggarwal,et al.  Regulation of proliferation, survival and apoptosis by members of the TNF superfamily. , 2003, Biochemical pharmacology.

[117]  U. Kelavkar,et al.  Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis. , 2001, Carcinogenesis.

[118]  Stefano Landi,et al.  Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer. , 2003, Cancer research.

[119]  R. Greil,et al.  Up-Regulation of Functional Chemokine Receptor CCR3 in Human Renal Cell Carcinoma , 2005, Clinical Cancer Research.

[120]  N. Terrault,et al.  Hepatitis C and hepatocellular carcinoma , 2001, Current treatment options in oncology.

[121]  G. Casey,et al.  Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity. , 2005, Cancer research.

[122]  Dallas Jones,et al.  Emerging roles of PPARS in inflammation and immunity , 2002, Nature Reviews Immunology.

[123]  H. Petri,et al.  Population based studies of biological antirheumatic drug use in southern Sweden: comparison with pharmaceutical sales , 2005, Annals of the rheumatic diseases.

[124]  J. Blay,et al.  Interleukin (IL)-10 and IL-6 are produced in vivo by non-Hodgkin's lymphoma cells and act as cooperative growth factors. , 1996, Cancer research.

[125]  M. Wilson,et al.  Co-localization of macrophage inflammatory protein-3alpha (Mip-3alpha) and its receptor, CCR6, promotes pancreatic cancer cell invasion. , 2004, Cancer journal.

[126]  B. Aggarwal.  Signalling pathways of the TNF superfamily: a double-edged sword , 2003, Nature Reviews Immunology.

[127]  A. Bisceglie,et al.  Hepatitis C and Hepatocellular Carcinoma , 1995, Seminars in liver disease.

[128]  S. Weitzman,et al.  Mechanisms of carcinogenesis and clinical features of asbestos-associated cancers. , 1996, Cancer investigation.

[129]  P. Treuting,et al.  Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice. , 2006, Cancer research.

[130]  M. Jourdan,et al.  Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. , 1989, Blood.

[131]  M. Smyth,et al.  Tumor Necrosis Factor Sustains the Generalized Lymphoproliferative Disorder ( gld ) Phenotype , 2000, The Journal of experimental medicine.

[132]  K. Lam,et al.  B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses , 2001, Molecular and Cellular Biology.

[133]  Z. Estrov,et al.  Role of interleukin-1 inhibitory molecules in therapy of acute and chronic myelogenous leukemia. , 1993, Leukemia & lymphoma.

[134]  A. Abdel‐Mageed,et al.  Activation of nuclear factor kappaB: potential role in metallothionein-mediated mitogenic response. , 1998, Cancer research.

[135]  T. Billiar,et al.  Molecular biology of nitric oxide synthases , 1998, Cancer and Metastasis Reviews.

[136]  J. Gershenwald,et al.  Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis. , 1997, The American journal of pathology.

[137]  A. Haman,et al.  Tumor necrosis factor alpha stimulates the growth of the clonogenic cells of acute myeloblastic leukemia in synergy with granulocyte/macrophage colony-stimulating factor , 1989, The Journal of experimental medicine.

[138]  R. Peek,et al.  Helicobacter infection and gastric neoplasia , 2006, The Journal of pathology.

[139]  P. Dhawan,et al.  Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. , 2002, Cancer research.

[140]  Jennifer Y. Zhang,et al.  NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. , 2003, Nature.

[141]  Jingqing Yang,et al.  Constitutive IκB Kinase Activity Correlates with Nuclear Factor-κB Activation in Human Melanoma Cells , 2001 .

[142]  F. Sinicrope,et al.  Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. , 2002, Cancer research.

[143]  M. Taketo,et al.  Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis. , 2003, Cancer research.

[144]  L. Neckers,et al.  IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis , 2003 .

[145]  Sankar Ghosh,et al.  NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[146]  B. Spiegelman,et al.  Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer , 1999 .

[147]  Steffen Mühldorfer,et al.  Activation of NFκB Represents the Central Event in the Neoplastic Progression Associated with Barrett's Esophagus: A Possible Link to the Inflammation and Overexpression of COX-2, PPARγ and Growth Factors , 2004, Digestive Diseases and Sciences.

[148]  R. DuBois,et al.  Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells , 1998, Cell.

[149]  T. Hagemann,et al.  Macrophages Induce Invasiveness of Epithelial Cancer Cells Via NF-κB and JNK1 , 2005, The Journal of Immunology.

[150]  T. Fahey,et al.  Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer. , 1999, Cancer research.

[151]  Shishir Shishodia,et al.  Molecular targets of dietary agents for prevention and therapy of cancer. , 2006, Biochemical pharmacology.

[152]  K. Takeda,et al.  Identity of differentiation inducing factor and tumour necrosis factor , 1986, Nature.

[153]  W. Jelkmann,et al.  Review: hypoxia-inducible factor-1 (HIF-1): a novel transcription factor in immune reactions. , 2005, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[154]  C. Denkert,et al.  Expression of cyclooxygenase 2 in human malignant melanoma. , 2001, Cancer research.

[155]  R. Ransohoff,et al.  The many roles of chemokines and chemokine receptors in inflammation. , 2006, The New England journal of medicine.

[156]  Peter J. Brown,et al.  Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ , 1997 .

[157]  D. Wang,et al.  Nuclear factor-kappa B activation by the CXC chemokine melanoma growth-stimulatory activity/growth-regulated protein involves the MEKK1/p38 mitogen-activated protein kinase pathway. , 2001, The Journal of biological chemistry.

[158]  James B. Mitchell,et al.  Erratum: Nuclear factor-κB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma (Cancer Research (September 2004) 64 (6511-6523) , 2004 .

[159]  Kazuhiro Usui,et al.  Proinflammatory Cytokine IL-1β Promotes Tumor Growth of Lewis Lung Carcinoma by Induction of Angiogenic Factors: In Vivo Analysis of Tumor-Stromal Interaction1 , 2002, The Journal of Immunology.

[160]  R. Foà,et al.  Production of tumor necrosis factor-alpha by B-cell chronic lymphocytic leukemia cells: a possible regulatory role of TNF in the progression of the disease. , 1990, Blood.

[161]  B. Freedman,et al.  Evidence for voltage modulation of IL-2 production in mitogen-stimulated human peripheral blood lymphocytes. , 1992, Journal of immunology.

[162]  S. Tsuji,et al.  Effects of interferon-beta on the cytokine production of astrocytes. , 2005, Journal of neuroimmunology.

[163]  A. Dennison,et al.  Role of Inflammation in Pancreatic Carcinogenesis and the Implications for Future Therapy , 2005, Pancreatology.

[164]  Debajit K. Biswas,et al.  NF-κB activation in human breast cancer specimens and its role in cell proliferation and apoptosis , 2004 .

[165]  Hiroyuki Yamamoto,et al.  Role of Matrix Metalloproteinase-7 (Matrilysin) in Human Cancer Invasion, Apoptosis, Growth, and Angiogenesis , 2006, Experimental biology and medicine.

[166]  D. Alberts,et al.  Analysis of Cyclooxygenase 2 (COX-2) Expression During Malignant Melanoma Progression , 2003, Cancer biology & therapy.

[167]  H. Kawai,et al.  Down-regulation of nuclear factor kappaB is required for p53-dependent apoptosis in X-ray-irradiated mouse lymphoma cells and thymocytes. , 1999, Cancer research.

[168]  J. Jackson,et al.  Oxidant-induced DNA damage of target cells. , 1988, The Journal of clinical investigation.

[169]  A. Ristimäki,et al.  Expression of cyclooxygenase-2 in human lung carcinoma. , 1998, Cancer research.

[170]  N. Perkins,et al.  p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor. , 2003, Molecular cell.

[171]  Y. Ben-Neriah,et al.  NF-κB functions as a tumour promoter in inflammation-associated cancer , 2004, Nature.

[172]  I. M. Neiman,et al.  [Inflammation and cancer]. , 1974, Patologicheskaia fiziologiia i eksperimental'naia terapiia.

[173]  T. Hla,et al.  The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia. , 2005, Cancer research.

[174]  G. Wahl,et al.  p53 stabilization is decreased upon NFκB activation , 2002 .

[175]  A. Richmond,et al.  Nuclear Factor-κB Activation by the CXC Chemokine Melanoma Growth-stimulatory Activity/Growth-regulated Protein Involves the MEKK1/p38 Mitogen-activated Protein Kinase Pathway* , 2001, The Journal of Biological Chemistry.

[176]  A. Hoffbrand,et al.  Interleukin-6 inhibits apoptosis and tumour necrosis factor induced proliferation of B-chronic lymphocytic leukaemia. , 1996, Leukemia & lymphoma.

[177]  C. Van Waes,et al.  The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma. , 1999, Cancer research.

[178]  A. Arlt,et al.  Autocrine Production of Interleukin 1β Confers Constitutive Nuclear Factor κB Activity and Chemoresistance in Pancreatic Carcinoma Cell Lines , 2002 .

[179]  A. Fulton,et al.  Selective cyclooxygenase (COX)-1 or COX-2 inhibitors control metastatic disease in a murine model of breast cancer. , 2002, Cancer research.

[180]  Gordon Stamp,et al.  Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. , 2002, Cancer research.

[181]  K. Zuckerman,et al.  The role of type I and type II tumor necrosis factor (TNF) receptors in the ability of TNF-alpha to transduce a proliferative signal in the human megakaryoblastic leukemic cell line Mo7e. , 1998, Cancer research.

[182]  Z. Werb,et al.  New functions for the matrix metalloproteinases in cancer progression , 2002, Nature Reviews Cancer.

[183]  F. Balkwill,et al.  Expression of both TNF-α receptor subtypes is essential for optimal skin tumour development , 2004, Oncogene.

[184]  M. Nair,et al.  From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer , 2006, Expert opinion on therapeutic targets.

[185]  M. Reiss,et al.  Tumor necrosis factor stimulates epithelial tumor cell motility. , 1991, Cancer research.

[186]  L. Nabors,et al.  Tumor necrosis factor alpha induces angiogenic factor up-regulation in malignant glioma cells: a role for RNA stabilization and HuR. , 2003, Cancer research.

[187]  C. Bucana,et al.  Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. , 2000, Cancer research.

[188]  Rinat Abramovitch,et al.  NF-kappaB functions as a tumour promoter in inflammation-associated cancer. , 2004, Nature.

[189]  W. Wu,et al.  Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking. , 2004, Toxicology.

[190]  H. Kuwano,et al.  Significance of contracted cholecystitis lesions as high risk for gallbladder carcinogenesis. , 2001, Cancer letters.

[191]  M. Turner,et al.  Tumor necrosis factor mediates autocrine growth inhibition in a chronic leukemia. , 1989, Journal of immunology.

[192]  C. Brosnan,et al.  Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. , 1990, Journal of immunology.

[193]  Robert C. Bast,et al.  Tumor Necrosis Factor α as an Autocrine and Paracrine Growth Factor for Ovarian Cancer: Monokine Induction of Tumor Cell Proliferation and Tumor Necrosis Factor α Expression , 1993 .

[194]  Andrea Varro,et al.  Helicobacter pylori Induces Plasminogen Activator Inhibitor 2 in Gastric Epithelial Cells through Nuclear Factor-κB and RhoA , 2004, Cancer Research.

[195]  D. Kelleher,et al.  Cellular Proliferation and Activation of NFκB Are Induced by Autocrine Production of Tumor Necrosis Factor α in the Human T Lymphoma Line HuT 78 (*) , 1995, The Journal of Biological Chemistry.

[196]  R. Eeles,et al.  Influence of cytokine gene polymorphisms on the development of prostate cancer. , 2002, Cancer research.

[197]  B. Spiegelman,et al.  Loss-of-function mutations in PPAR gamma associated with human colon cancer. , 1999, Molecular cell.

[198]  K. Vousden,et al.  Role of NF-κB in p53-mediated programmed cell death , 2000, Nature.

[199]  W. Longo,et al.  Colorectal cancer in patients with inflammatory bowel disease. , 2005, Clinical colorectal cancer.

[200]  C. Grommes,et al.  Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists. , 2004, The Lancet. Oncology.

[201]  J. Cusack,et al.  Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB , 1999, Nature Medicine.

[202]  Fraser Dw.  Letter: Whooping-cough vaccination. , 1976, British medical journal.

[203]  J. Blay,et al.  Tumor necrosis factor as an autocrine growth factor for neuroblastoma. , 1992, Cancer research.

[204]  C. Grommes,et al.  Antineoplastic effects of peroxisome proliferatoractivated receptor γ agonists , 2004 .

[205]  H. Kawamata,et al.  Enhancement of transformation in vitro of a nontumorigenic rat urothelial cell line by interleukin 6. , 1995, Cancer research.

[206]  B. Aggarwal,et al.  Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. , 2005, Biochemical pharmacology.

[207]  T. Shono,et al.  Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis , 1997, Molecular and cellular biology.

[208]  Jennifer Y. Zhang,et al.  NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia , 2003, Nature.

[209]  S. Brandt,et al.  NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[210]  R. Clark.  The role of PPARs in inflammation and immunity , 2002, Journal of leukocyte biology.

[211]  D. Hanahan,et al.  MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis , 2000, Cell.

[212]  P. Chiao,et al.  Identification of an autoregulatory feedback pathway involving interleukin-1alpha in induction of constitutive NF-kappaB activation in pancreatic cancer cells. , 2004, The Journal of biological chemistry.

[213]  H. Ljunggren,et al.  Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappaB inhibition. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[214]  H. Nakshatri,et al.  NF-κ B Promotes Breast Cancer Cell Migration and Metastasis by Inducing the Expression of the Chemokine Receptor CXCR4* , 2003, Journal of Biological Chemistry.

[215]  T. Shono,et al.  Cyclooxygenase-2 expression in human gliomas: prognostic significance and molecular correlations. , 2001, Cancer research.

[216]  G. Dong,et al.  Expression of a Dominant-Negative Mutant Inhibitor-κBα of Nuclear Factor-κB in Human Head and Neck Squamous Cell Carcinoma Inhibits Survival, Proinflammatory Cytokine Expression, and Tumor Growth in Vivo , 1999 .

[217]  W. Foulkes,et al.  Tumor necrosis factor and its receptors in human ovarian cancer. Potential role in disease progression. , 1993, The Journal of clinical investigation.

[218]  L. Murray,et al.  Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study. , 2005, World journal of gastroenterology.

[219]  B. Mian,et al.  Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. , 2002, The American journal of pathology.

[220]  A. Sahin,et al.  Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. , 2002, Cancer research.

[221]  P. Chiao,et al.  Identification of an Autoregulatory Feedback Pathway Involving Interleukin-1α in Induction of Constitutive NF-κB Activation in Pancreatic Cancer Cells* , 2004, Journal of Biological Chemistry.

[222]  P. Tripathi.  Nitric oxide and immune response. , 2007, Indian journal of biochemistry & biophysics.

[223]  F. Balkwill,et al.  Expression of both TNF-alpha receptor subtypes is essential for optimal skin tumour development. , 2004, Oncogene.

[224]  A. Sabichi,et al.  Differential expression of cyclooxygenase-2 and its regulation by tumor necrosis factor-alpha in normal and malignant prostate cells. , 2001, Cancer research.

[225]  N. Perkins,et al.  p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor , 2003 .

[226]  P. Vogt,et al.  Tumor Necrosis Factor α and Interleukin 1α Induce Anchorage Independence in v-jun Transgenic Murine Cells , 1993 .

[227]  E. Jabłońska,et al.  TNF family molecules in the serum of patients with B-cell chronic lymphocytic leukemia (B-CLL) , 2005, Leukemia & lymphoma.

[228]  E. Hahn,et al.  Activation of NFkappaB represents the central event in the neoplastic progression associated with Barrett's esophagus: a possible link to the inflammation and overexpression of COX-2, PPARgamma and growth factors. , 2004, Digestive diseases and sciences.

[229]  L. Coussens,et al.  Cancer: An inflammatory link , 2004, Nature.

[230]  C. Van Waes,et al.  Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo. , 1999, Cancer research.

[231]  S. Hamilton-Dutoit,et al.  Intense inflammation in bladder carcinoma is associated with angiogenesis and indicates good prognosis , 2002, British Journal of Cancer.

[232]  P. Khavari,et al.  Alterations in NF-kappaB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappaB. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[233]  Philippe Calmant,et al.  Nuclear factor – κB-dependent regulation of p53 gene expression induced by daunomycin genotoxic drug , 1998, Oncogene.

[234]  D. Bar-Sagi,et al.  Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. , 2004, Cancer cell.

[235]  Alberto Mantovani,et al.  Inflammation and cancer: back to Virchow? , 2001, The Lancet.

[236]  M. Tomonaga,et al.  Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers. , 2001, Cancer research.

[237]  E. Schwarz,et al.  Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone. , 2005, Cancer research.