Bio-hybrid electronic and photonic devices

Bio-hybrid devices, combining electronic and photonic components with cells, tissues, and organs, hold potential for advancing our understanding of biology, physiology, and pathologies and for treating a wide range of conditions and diseases. In this review, I describe the devices, materials, and technologies that enable bio-hybrid devices and provide examples of their utilization at multiple biological scales ranging from the subcellular to whole organs. Finally, I describe the outcomes of a National Science Foundation (NSF)–funded workshop envisioning potential applications of these technologies to improve health outcomes and quality of life.

[1]  Michael R. Bryan,et al.  Disposable photonics for cost-effective clinical bioassays: application to COVID-19 antibody testing. , 2021, Lab on a chip.

[2]  S. Y. Siew,et al.  Review of Silicon Photonics Technology and Platform Development , 2021, Journal of Lightwave Technology.

[3]  M. Fussenegger,et al.  Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice , 2020, Science.

[4]  Wenshuai Chen,et al.  Cellulose‐Based Flexible Functional Materials for Emerging Intelligent Electronics , 2020, Advanced materials.

[5]  V. Tsukruk,et al.  Biopolymeric photonic structures: design, fabrication, and emerging applications. , 2020, Chemical Society reviews.

[6]  Tal Dvir,et al.  Engineering Smart Hybrid Tissues with Built-In Electronics , 2020, iScience.

[7]  Stephanie Naufel,et al.  DARPA investment in peripheral nerve interfaces for prosthetics, prescriptions, and plasticity , 2019, Journal of Neuroscience Methods.

[8]  Bozhi Tian,et al.  Nano-enabled cellular engineering for bioelectric studies , 2019, Nano Research.

[9]  Kaushik Parida,et al.  Emerging Soft Conductors for Bioelectronic Interfaces , 2019, Advanced Functional Materials.

[10]  M. Griffith,et al.  Manipulating nanoscale structure to control functionality in printed organic photovoltaic, transistor and bioelectronic devices , 2019, Nanotechnology.

[11]  Jonathan R Soucy,et al.  Instrumented Microphysiological Systems for Real-Time Measurement and Manipulation of Cellular Electrochemical Processes , 2019, iScience.

[12]  Wen-Yih Chen,et al.  Field-Effect Transistor Biosensors for Biomedical Applications: Recent Advances and Future Prospects , 2019, Sensors.

[13]  Douglas D. Coolbaugh,et al.  The AIM Photonics MPW: A Highly Accessible Cutting Edge Technology for Rapid Prototyping of Photonic Integrated Circuits , 2019, IEEE Journal of Selected Topics in Quantum Electronics.

[14]  C. Dagdeviren,et al.  The Future of Neuroimplantable Devices: A Materials Science and Regulatory Perspective , 2019, Advanced materials.

[15]  Bozhi Tian,et al.  Nanowired Bioelectric Interfaces. , 2019, Chemical reviews.

[16]  Caterina Ciminelli,et al.  Silicon photonic biosensors , 2019, IET Optoelectronics.

[17]  John A Rogers,et al.  Bio-Integrated Wearable Systems: A Comprehensive Review. , 2019, Chemical reviews.

[18]  Feng Yan,et al.  Functionalized Organic Thin Film Transistors for Biosensing. , 2019, Accounts of chemical research.

[19]  H. Choi,et al.  Light‐responsive nanomedicine for biophotonic imaging and targeted therapy , 2019, Advanced drug delivery reviews.

[20]  Dae-Hyeong Kim,et al.  Wearable and Implantable Soft Bioelectronics Using Two-Dimensional Materials. , 2018, Accounts of chemical research.

[21]  Xuanhe Zhao,et al.  Hydrogel bioelectronics. , 2019, Chemical Society reviews.

[22]  Menahem Y. Rotenberg,et al.  Optical stimulation of cardiac cells with a polymer-supported silicon nanowire matrix , 2018, Proceedings of the National Academy of Sciences.

[23]  B. Tian,et al.  Inorganic semiconductor biointerfaces , 2018, Nature Reviews Materials.

[24]  D. Rincon-Limas,et al.  Bringing Light to Transcription: The Optogenetics Repertoire , 2018, Front. Genet..

[25]  Zhiwen Liu,et al.  Polymeric biomaterials for biophotonic applications , 2018, Bioactive materials.

[26]  Xing Sheng,et al.  Biocompatible and Implantable Optical Fibers and Waveguides for Biomedicine , 2018, Materials.

[27]  J. Travas-sejdic,et al.  Molecular Approach to Conjugated Polymers with Biomimetic Properties. , 2018, Accounts of chemical research.

[28]  Xiao Yang,et al.  Mesh electronics: a new paradigm for tissue-like brain probes , 2018, Current Opinion in Neurobiology.

[29]  Wei Qi,et al.  Self-assembled polymer nanocomposites for biomedical application , 2018 .

[30]  J. Víteček,et al.  Evaluation and improvement of organic semiconductors’ biocompatibility towards fibroblasts and cardiomyocytes , 2018 .

[31]  G. Braun,et al.  Graphene biointerfaces for optical stimulation of cells , 2018, Science Advances.

[32]  Bozhi Tian,et al.  Rational Design of Semiconductor Nanostructures for Functional Subcellular Interfaces. , 2018, Accounts of chemical research.

[33]  Michal Cifra,et al.  Roadmap on semiconductor–cell biointerfaces , 2018, Physical biology.

[34]  M. Nair,et al.  Near-infrared biophotonics-based nanodrug release systems and their potential application for neuro-disorders , 2018, Expert opinion on drug delivery.

[35]  Bozhi Tian,et al.  Photoelectrochemical modulation of neuronal activity with free-standing coaxial silicon nanowires , 2018, Nature Nanotechnology.

[36]  Tal Dvir,et al.  Tissue–electronics interfaces: from implantable devices to engineered tissues , 2018 .

[37]  Bozhi Tian,et al.  Nanoscale silicon for subcellular biointerfaces. , 2017, Journal of materials chemistry. B.

[38]  Xiao Yang,et al.  Syringe-injectable mesh electronics integrate seamlessly with minimal chronic immune response in the brain , 2017, Proceedings of the National Academy of Sciences.

[39]  Rona S. Gertner,et al.  CMOS nanoelectrode array for all-electrical intracellular electrophysiological imaging. , 2017, Nature nanotechnology.

[40]  Yidan Wang,et al.  Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice , 2017, Science Translational Medicine.

[41]  Seunghun Hong,et al.  Nanoscale hybrid systems based on carbon nanotubes for biological sensing and control , 2017, Bioscience reports.

[42]  Houyu Wang,et al.  Recent Advances in Silicon Nanomaterial-Based Fluorescent Sensors , 2017, Sensors.

[43]  Stefan Kalies,et al.  Modulation of cardiomyocyte activity using pulsed laser irradiated gold nanoparticles. , 2017, Biomedical optics express.

[44]  John F. Zimmerman,et al.  Cellular uptake and dynamics of unlabeled freestanding silicon nanowires , 2016, Science Advances.

[45]  Sungwoo Nam,et al.  Bioelectronics with two-dimensional materials , 2016 .

[46]  Michael C. McAlpine,et al.  3D Printed Bionic Nanodevices. , 2016, Nano today.

[47]  Jia Liu,et al.  Three-dimensional mapping and regulation of action potential propagation in nanoelectronics innervated tissues , 2016, Nature nanotechnology.

[48]  Md. Sajibul Alam Bhuyan,et al.  Synthesis of graphene , 2016, International Nano Letters.

[49]  Huanyu Cheng,et al.  Bioresorbable silicon electronic sensors for the brain , 2016, Nature.

[50]  Mary A. Arugula,et al.  Review—Nanocarbon-Based Multi-Functional Biointerfaces: Design and Applications , 2016 .

[51]  Mandeep Singh,et al.  Printable and flexible electronics: from TFTs to bioelectronic devices , 2015 .

[52]  T. Hua,et al.  Flexible Organic Electronics in Biology: Materials and Devices , 2015, Advanced materials.

[53]  Soohyung Park,et al.  A Review of Patterned Organic Bioelectronic Materials and their Biomedical Applications , 2015, Advanced materials.

[54]  C. Lieber,et al.  Three-dimensional macroporous nanoelectronic networks as minimally invasive brain probes. , 2015, Nature materials.

[55]  N. Voelcker,et al.  Applications of zero-valent silicon nanostructures in biomedicine. , 2015, Nanomedicine.

[56]  Bozhi Tian,et al.  Free-Standing Kinked Silicon Nanowires for Probing Inter- and Intracellular Force Dynamics. , 2015, Nano letters.

[57]  Zhigang Suo,et al.  Syringe-injectable electronics. , 2015, Nature nanotechnology.

[58]  G. Wallace,et al.  Nano-bioelectronics via dip-pen nanolithography , 2015 .

[59]  Changqi Huan,et al.  Silicon nanoparticles: Preparation, properties, and applications , 2014 .

[60]  C. Fan,et al.  Silicon nanomaterials platform for bioimaging, biosensing, and cancer therapy. , 2014, Accounts of chemical research.

[61]  M. Spira,et al.  Multi-electrode array technologies for neuroscience and cardiology. , 2013, Nature nanotechnology.

[62]  Charles M. Lieber,et al.  Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. , 2012, Nature materials.

[63]  Huanyu Cheng,et al.  A Physically Transient Form of Silicon Electronics , 2012, Science.

[64]  Gilles Horowitz,et al.  Advances in organic transistor-based biosensors: from organic electrochemical transistors to electrolyte-gated organic field-effect transistors , 2012, Analytical and Bioanalytical Chemistry.

[65]  Lief E. Fenno,et al.  The development and application of optogenetics. , 2011, Annual review of neuroscience.

[66]  Zhenhui Kang,et al.  Small-sized silicon nanoparticles: new nanolights and nanocatalysts. , 2011, Nanoscale.

[67]  B. Nabet,et al.  In Vitro Biocompatibility of n‐Type and Undoped Silicon Nanowires , 2011 .

[68]  Joseph E Marine,et al.  50th Anniversary of the first successful permanent pacemaker implantation in the United States: historical review and future directions. , 2010, The American journal of cardiology.

[69]  Charles M. Lieber,et al.  Three-Dimensional, Flexible Nanoscale Field-Effect Transistors as Localized Bioprobes , 2010, Science.

[70]  Andrew F M Johnstone,et al.  Microelectrode arrays: a physiologically based neurotoxicity testing platform for the 21st century. , 2010, Neurotoxicology.

[71]  Austin R. Duke,et al.  Optical pacing of the embryonic heart , 2010, Nature photonics.

[72]  Bozhi Tian,et al.  Nanowire transistor arrays for mapping neural circuits in acute brain slices , 2010, Proceedings of the National Academy of Sciences.

[73]  Raúl J. Martín-Palma,et al.  Biomedical applications of nanostructured porous silicon: a review , 2010 .

[74]  Michael Levin,et al.  Bioelectric controls of cell proliferation: Ion channels, membrane voltage and the cell cycle , 2009, Cell cycle.

[75]  Charles M Lieber,et al.  Flexible electrical recording from cells using nanowire transistor arrays , 2009, Proceedings of the National Academy of Sciences.

[76]  J. Mink,et al.  Deep brain stimulation. , 2006, Annual review of neuroscience.

[77]  G. Clark The multiple-channel cochlear implant: the interface between sound and the central nervous system for hearing, speech, and language in deaf people—a personal perspective , 2006, Philosophical Transactions of the Royal Society B: Biological Sciences.

[78]  John A. Pedersen,et al.  Mechanobiology in the Third Dimension , 2005, Annals of Biomedical Engineering.

[79]  K. Deisseroth,et al.  Millisecond-timescale, genetically targeted optical control of neural activity , 2005, Nature Neuroscience.

[80]  E. Bamberg,et al.  Channelrhodopsin-2, a directly light-gated cation-selective membrane channel , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[81]  H. Fukuzawa,et al.  Archaeal-type rhodopsins in Chlamydomonas: model structure and intracellular localization. , 2003, Biochemical and biophysical research communications.

[82]  E. Bamberg,et al.  Channelrhodopsin-1: A Light-Gated Proton Channel in Green Algae , 2002, Science.

[83]  Oleg A. Sineshchekov,et al.  Two rhodopsins mediate phototaxis to low- and high-intensity light in Chlamydomonas reinhardtii , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[84]  G. Gross,et al.  Stimulation of monolayer networks in culture through thin-film indium-tin oxide recording electrodes , 1993, Journal of Neuroscience Methods.

[85]  G. Loeb,et al.  A miniature microelectrode array to monitor the bioelectric activity of cultured cells. , 1972, Experimental cell research.