Effects of age on elements of insulin-signaling pathway in central nervous system of rats

[1]  S. Woods,et al.  Central nervous system control of food intake , 2000, Nature.

[2]  A. Zaia,et al.  Insulin receptors in the brain cortex of aging mice , 2000, Mechanisms of Ageing and Development.

[3]  M. Yamada,et al.  Shp‐2 Specifically Regulates Several Tyrosine‐Phosphorylated Proteins in Brain‐Derived Neurotrophic Factor Signal , 2000, Journal of neurochemistry.

[4]  L. Velloso,et al.  Insulin induces tyrosine phosphorylation of the insulin receptor and SHC, and SHC/GRB2 association in cerebellum but not in forebrain cortex of rats , 1999, Brain Research.

[5]  C. Kahn,et al.  Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. , 1999, The Journal of clinical investigation.

[6]  S. Bennett,et al.  Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats , 1999, Neuroscience.

[7]  L. Velloso,et al.  Insulin induces tyrosine phosphorylation of Shc and stimulates Shc/GRB2 association in insulin-sensitive tissues of the intact rat , 1998, Endocrine.

[8]  A. Zaia,et al.  Insulin receptors in mouse brain: age-related modifications are corrected by thymus graft , 1997, Mechanisms of Ageing and Development.

[9]  M. Gulisano,et al.  Expression and activation of SH2/PTB-containing ShcA adaptor protein reflects the pattern of neurogenesis in the mammalian brain. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[10]  S. Shoelson,et al.  Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking , 1997, Molecular and cellular biology.

[11]  C. Kahn,et al.  Cross-talk between the insulin and angiotensin signaling systems. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[12]  X. Xu,et al.  Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats , 1995, Neuroscience.

[13]  E. Renard,et al.  Insulin receptor substrate-1 (IRS-1) distribution in the rat central nervous system , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[14]  M. White,et al.  Insulin receptor substrate-1 (IRS-1) expression in rat brain. , 1994, Endocrinology.

[15]  C. Roberts,et al.  Elevated protein tyrosine phosphatase activity and increased membrane viscosity are associated with impaired activation of the insulin receptor kinase in old rats. , 1994, The Biochemical journal.

[16]  C. Kahn,et al.  Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats. , 1993, The Journal of clinical investigation.

[17]  S. Woods,et al.  Insulin in the brain: a hormonal regulator of energy balance. , 1992, Endocrine reviews.

[18]  C. Bondy,et al.  Transient IGF-I gene expression during the maturation of functionally related central projection neurons , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[19]  R. Moxley,et al.  Location of phosphotyrosine-containing proteins by immunocytochemistry in the rat forebrain corresponds to the distribution of the insulin receptor. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[20]  C. Kahn,et al.  Conformational changes in the alpha- and beta-subunits of the insulin receptor identified by anti-peptide antibodies. , 1989, The Journal of biological chemistry.

[21]  C. Jacquemin,et al.  Insulin and insulin-like growth factor 1 receptors during postnatal development of rat brain. , 1988, Brain research.

[22]  C. Pert,et al.  Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas , 1986, Neuroscience.

[23]  M. Raizada,et al.  Adult-level insulin binding is present in term fetal rat CNS membranes , 1982, Brain Research.

[24]  M. Brownstein,et al.  Identification of insulin in rat brain. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[25]  M. Brownstein,et al.  Insulin receptors are widely distributed in the central nervous system of the rat , 1978, Nature.

[26]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[27]  C. Kahn,et al.  A Cascade of Tyrosine Autophosphorylation in the &Subunit Activates the Phosphotransferase of the Insulin Receptor* , 2001 .

[28]  N. Richardson,et al.  Localisation of insulin-like growth factor-I (IGF-I) immunoreactivity in the olivocerebellar system of developing and adult rats. , 1997, Brain research. Developmental brain research.

[29]  C R Carvalho,et al.  Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats. , 1996, Endocrinology.