Loss of growth factor receptor signaling in the oral mucosa during primary SIV infection may enhance apoptosis and promote pathogenesis

Background  The development of susceptibility to secondary pathogenic infections in the oral cavity during HIV infection is likely to result from or coincide with deterioration of the local mucosal immune system.

[1]  P. Froment,et al.  Mdm2 exerts pro-apoptotic activities by antagonizing insulin-like growth factor-I-mediated survival , 2008, Cell cycle.

[2]  Guillermina Lozano,et al.  Mdm2 and Mdm4 Loss Regulates Distinct p53 Activities , 2008, Molecular Cancer Research.

[3]  Jay K Kolls,et al.  Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut , 2008, Nature Medicine.

[4]  F. X. Lü,et al.  Oral Mucosal Immunity and HIV/SIV Infection , 2007, Journal of dental research.

[5]  M. Sułkowska,et al.  Insulin‐Like Growth Factor‐I Receptor Correlates with Connexin 26 and Bcl‐xL Expression in Human Colorectal Cancer , 2006, Annals of the New York Academy of Sciences.

[6]  G. Wahl,et al.  Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4 , 2006, Cell Death and Differentiation.

[7]  R. Blumenthal,et al.  Human β-Defensins Suppress Human Immunodeficiency Virus Infection: Potential Role in Mucosal Protection , 2005, Journal of Virology.

[8]  Michael D. George,et al.  Early Antiretroviral Therapy for Simian Immunodeficiency Virus Infection Leads to Mucosal CD4+ T-Cell Restoration and Enhanced Gene Expression Regulating Mucosal Repair and Regeneration , 2005, Journal of Virology.

[9]  D. Coppola,et al.  Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway. , 2003, Cancer research.

[10]  C. Ho,et al.  Immunohistochemical expression of angiogenic cytokines and their receptors in reactive benign lymph nodes and non-Hodgkin lymphoma. , 2003, Annals of diagnostic pathology.

[11]  M. Pollak,et al.  Insulin-like growth factor-I antagonizes the antiproliferative effects of cyclooxygenase-2 inhibitors on BxPC-3 pancreatic cancer cells. , 2002, Cancer research.

[12]  S. Challacombe,et al.  Oral mucosal immunity and HIV infection: current status. , 2002, Oral diseases.

[13]  M. Simon,et al.  Antiretroviral Agents Restore Mycobacterium-Specific T-Cell Immune Responses and Facilitate Controlling a Fatal Tuberculosis-Like Disease in Macaques Coinfected with Simian Immunodeficiency Virus andMycobacterium bovis BCG , 2001, Journal of Virology.

[14]  M. Murphey-Corb,et al.  Rhesus lymphocryptovirus infection during the progression of SAIDS and SAIDS-associated lymphoma in the rhesus macaque. , 2000, AIDS research and human retroviruses.

[15]  P. Didier,et al.  B-Cell Leukemia in a Rhesus Macaque (Macaca mulatta) Infected with Simian Immunodeficiency Virus , 2000, Leukemia & lymphoma.

[16]  A. Schmidt,et al.  Activation in vivo of retroperitoneal fibromatosis-associated herpesvirus, a simian homologue of human herpesvirus-8. , 1999, The Journal of general virology.

[17]  O. Larsson,et al.  Expression of the insulin-like growth factor-1 receptor and its anti-apoptotic effect in malignant melanoma: a potential therapeutic target , 1998, Melanoma research.

[18]  J. Capitanio,et al.  Cytomegalovirus and simian immunodeficiency virus coinfection: longitudinal study of antibody responses and disease progression. , 1997, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

[19]  M. Hidalgo,et al.  EGFR inhibitor-mediated apoptosis in solid tumors. , 2007, Journal of experimental therapeutics & oncology.

[20]  Arnab Chakravarti,et al.  Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. , 2002, Cancer research.