Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4.

[1]  M. Forgac.  Structure, function and regulation of the vacuolar (H+)‐ATPases , 1998, FEBS letters.

[2]  F. Brodsky,et al.  A Dominant-negative Clathrin Mutant Differentially Affects Trafficking of Molecules with Distinct Sorting Motifs in the Class II Major Histocompatibility Complex (MHC) Pathway , 1998, The Journal of cell biology.

[3]  B. Peterlin,et al.  Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus , 1997, Journal of virology.

[4]  M. Greenberg,et al.  Co‐localization of HIV‐1 Nef with the AP‐2 adaptor protein complex correlates with Nef‐induced CD4 down‐regulation , 1997, The EMBO journal.

[5]  J. Bonifacino,et al.  Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family. , 1997, Virology.

[6]  K. Krause,et al.  Nef-mediated Clathrin-coated Pit Formation , 1997, The Journal of cell biology.

[7]  M. Daucher,et al.  Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Yuan Zhang,et al.  Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[9]  R. Desrosiers,et al.  A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation , 1997, Journal of virology.

[10]  J. Bonifacino,et al.  Linking cargo to vesicle formation: receptor tail interactions with coat proteins. , 1997, Current opinion in cell biology.

[11]  J. Skowroński,et al.  Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling , 1997, The EMBO journal.

[12]  C. Doyle,et al.  Nef proteins encoded by human and simian immunodeficiency viruses induce the accumulation of endosomes and lysosomes in human T cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[13]  T. Stevens,et al.  Structure, function and regulation of the vacuolar (H+)-ATPase. , 1997, Annual review of cell and developmental biology.

[14]  A. Abo,et al.  CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1 , 1996, Current Biology.

[15]  J. Bonifacino,et al.  Sequence requirements for the recognition of tyrosine‐based endocytic signals by clathrin AP‐2 complexes. , 1996, The EMBO journal.

[16]  C. Cheng‐Mayer,et al.  Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques , 1996, Current Biology.

[17]  A. Wilde,et al.  In vivo phosphorylation of adaptors regulates their interaction with clathrin , 1996, The Journal of cell biology.

[18]  H. Geuze,et al.  The tyrosine‐based lysosomal targeting signal in lamp‐1 mediates sorting into Golgi‐derived clathrin‐coated vesicles. , 1996, The EMBO journal.

[19]  R. Siliciano,et al.  Human Immunodeficiency Virus Type 1 Envelope Protein Endocytosis Mediated by a Highly Conserved Intrinsic Internalization Signal in the Cytoplasmic Domain of gp41 Is Suppressed in the Presence of the Pr55 Precursor Protein , 1996 .

[20]  J. Marsh,et al.  Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family , 1996, Journal of virology.

[21]  S. Grzesiek,et al.  The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR. , 1996, Biochemistry.

[22]  Bradley L. Smith,et al.  The HIV Nef Protein Associates with Protein Kinase C Theta* , 1996, The Journal of Biological Chemistry.

[23]  J. Otto,et al.  Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-Iiodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site (*) , 1996, The Journal of Biological Chemistry.

[24]  D. Olive,et al.  Physical and Functional Interaction of Nef with Lck , 1996, The Journal of Biological Chemistry.

[25]  D. Trono,et al.  Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation. , 1996, Virology.

[26]  G. Milanesi,et al.  Nef-CD4 physical interaction sensed with the yeast two-hybrid system. , 1996, Virology.

[27]  A. Fauci,et al.  Immunopathogenesis of HIV infection. , 1996, Annual review of microbiology.

[28]  J. Bonifacino,et al.  An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans‐Golgi network localization and internalization from the cell surface. , 1995, The EMBO journal.

[29]  R. Desrosiers,et al.  Identification of a nef allele that causes lymphocyte activation and acute disease in Macaque monkeys , 1995, Cell.

[30]  D. Trono,et al.  HIV accessory proteins: Leading roles for the supporting cast , 1995, Cell.

[31]  W C Greene,et al.  Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef , 1995, Journal of virology.

[32]  Y. Yarden,et al.  Roles for a Cytoplasmic Tyrosine and Tyrosine Kinase Activity in the Interactions of Neu Receptors with Coated Pits (*) , 1995, The Journal of Biological Chemistry.

[33]  D. Baltimore,et al.  Proline‐rich (PxxP) motifs in HIV‐1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down‐regulation of CD4. , 1995, The EMBO journal.

[34]  Q. Liu,et al.  Activity and in vitro reassembly of the coated vesicle (H+)-ATPase requires the 50-kDa subunit of the clathrin assembly complex AP-2. , 1994, The Journal of biological chemistry.

[35]  D. Richman,et al.  Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1. , 1994, Virology.

[36]  B. Cullen.  The role of Nef in the replication cycle of the human and simian immunodeficiency viruses. , 1994, Virology.

[37]  M. Harris,et al.  Myristoylation-dependent binding of HIV-1 Nef to CD4. , 1994, Journal of molecular biology.

[38]  S. Rhee,et al.  Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4 , 1994, Journal of Virology.

[39]  C. Cheng‐Mayer,et al.  HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. , 1994, Immunity.

[40]  G. Aldrovandi,et al.  Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity , 1994, Journal of virology.

[41]  M. Lenburg,et al.  Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain , 1994, Cell.

[42]  E. Roilides.  Host defense abnormalities as causes of increased susceptibility to infections in children with HIV infection. , 1994, Zentralblatt fur Bakteriologie : international journal of medical microbiology.

[43]  C. Thurieau,et al.  The 50 kDa protein subunit of assembly polypeptide (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on threonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides. , 1993, The Biochemical journal.

[44]  T. Stevens,et al.  VMA13 encodes a 54-kDa vacuolar H(+)-ATPase subunit required for activity but not assembly of the enzyme complex in Saccharomyces cerevisiae. , 1993, The Journal of biological chemistry.

[45]  O. Danos,et al.  Reduced cell surface expression of processed human immunodeficiency virus type 1 envelope glycoprotein in the presence of Nef , 1993, Journal of virology.

[46]  I. Jones,et al.  Legitimate and illegitimate cleavage of human immunodeficiency virus glycoproteins by furin , 1993, Journal of virology.

[47]  B. Cullen,et al.  Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection , 1993, The Journal of experimental medicine.

[48]  M. Forgac,et al.  The coated vesicle vacuolar (H+)-ATPase associates with and is phosphorylated by the 50-kDa polypeptide of the clathrin assembly protein AP-2. , 1993, The Journal of biological chemistry.

[49]  F. Brodsky,et al.  Adaptor self‐aggregation, adaptor‐receptor recognition and binding of alpha‐adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin‐coated pits. , 1993, The EMBO journal.

[50]  S. Elledge,et al.  The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. , 1993, Genes & development.

[51]  J. Garcia,et al.  The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4 , 1993, Journal of virology.

[52]  R. Desrosiers,et al.  Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. , 1992, Science.

[53]  T. Andrésson,et al.  Bovine papillomavirus E5 oncoprotein binds to the 16K component of vacuolar H+-ATPases , 1991, Nature.

[54]  D. Baltimore,et al.  Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[55]  R. Desrosiers,et al.  Importance of the nef gene for maintenance of high virus loads and for development of AIDS , 1991, Cell.

[56]  J. Garcia,et al.  Serine phosphorylation-independent downregulation of cell-surface CD4 by nef , 1991, Nature.

[57]  D. Richman,et al.  Alternative splice acceptor utilization during human immunodeficiency virus type 1 infection of cultured cells , 1990, Journal of virology.

[58]  M. Reitz,et al.  Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages , 1990, Journal of virology.

[59]  R. Axel,et al.  CD4: Collaborator in immune recognition and HIV infection , 1990, Cell.

[60]  R. Schlegel,et al.  The E5 oncoprotein of bovine papillomavirus binds to a 16 kd cellular protein. , 1990, The EMBO journal.

[61]  J. Parnes.  Molecular biology and function of CD4 and CD8. , 1989, Advances in immunology.

[62]  R. Desrosiers,et al.  Use of Infectious Molecular Clones of Simian Immunodeficiency Virus for Pathogenesis Studies , 1989, Journal of medical primatology.

[63]  Gilcher Ro.  Human retroviruses and AIDS. , 1988 .

[64]  P. Luciw,et al.  Molecular biology of HIV. , 1988, AIDS.

[65]  B. Guy,et al.  HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product , 1987, Nature.

[66]  J. Mcdougal,et al.  Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry. , 1986, Journal of immunology.