Dynamics of Posttranslational Modification Systems: Recent Progress and Future Directions.

Post-translational modification (PTM) of proteins plays a key role in signal transduction, and hence significant effort has gone toward understanding how PTM networks process information. This involves, on the theory side, analyzing the dynamical systems arising from such networks. Which networks are, for instance, bistable? Which networks admit sustained oscillations? Which parameter values enable such behaviors? In this Perspective, we highlight recent progress in this area and point out some important future directions.

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