Irreversible electroporation of the pancreas: Definitive local therapy without systemic effects

The use of thermal tumor ablative techniques in the pancreas is limited due to the risk of pancreatitis and damage to major vascular structures. Irreversible electroporation (IRE) is a non‐thermal ablation technique that could allow ablation in the pancreas while preserving vital surrounding blood vessels. The aim of this study was to assess the safety and ablation volume of IRE in porcine pancreatic tissue.

[1]  Rafael V. Davalos,et al.  The Feasibility of Irreversible Electroporation for the Treatment of Breast Cancer and Other Heterogeneous Systems , 2009, Annals of Biomedical Engineering.

[2]  L. Mir,et al.  Therapeutic perspectives of in vivo cell electropermeabilization. , 2001, Bioelectrochemistry.

[3]  Boris Rubinsky,et al.  The Effect of Irreversible Electroporation on Blood Vessels , 2007, Technology in cancer research & treatment.

[4]  E. Patterson,et al.  Radiofrequency ablation of porcine liver in vivo: effects of blood flow and treatment time on lesion size. , 1998, Annals of surgery.

[5]  Boris Rubinsky,et al.  In vivo results of a new focal tissue ablation technique: irreversible electroporation , 2006, IEEE Transactions on Biomedical Engineering.

[6]  Jon F Edd,et al.  Mathematical Modeling of Irreversible Electroporation for Treatment Planning , 2007, Technology in cancer research & treatment.

[7]  Boris Rubinsky,et al.  In vivo imaging of irreversible electroporation by means of electrical impedance tomography , 2009, Physics in medicine and biology.

[8]  A. Siriwardena,et al.  Development and Validation of an Experimental Model for the Assessment of Radiofrequency Ablation of Pancreatic Parenchyma , 2005, Pancreas.

[9]  Y. Glinka,et al.  Electroporation-enhanced nonviral gene transfer for the prevention or treatment of immunological, endocrine and neoplastic diseases. , 2006, Current gene therapy.

[10]  G. Gazelle,et al.  EUS-guided radiofrequency ablation in the pancreas: results in a porcine model. , 1999, Gastrointestinal endoscopy.

[11]  Rafael V. Davalos,et al.  Pilot study of irreversible electroporation for intracranial surgery , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[12]  Stephen T Kee,et al.  Imaging Guided Percutaneous Irreversible Electroporation: Ultrasound and Immunohistological Correlation , 2007, Technology in cancer research & treatment.

[13]  A. Siriwardena,et al.  Radiofrequency ablation of the pancreas. II: Intra-operative ablation of non-resectable pancreatic cancer. A description of technique and initial outcome. , 2005, JOP : Journal of the pancreas.

[14]  Boris Rubinsky,et al.  Irreversible Electroporation: A New Ablation Modality — Clinical Implications , 2007, Technology in cancer research & treatment.

[15]  A. Siriwardena,et al.  Radiofrequency ablation of the pancreas. I: Definition of optimal thermal kinetic parameters and the effect of simulated portal venous circulation in an ex-vivo porcine model. , 2005, JOP : Journal of the pancreas.

[16]  Boris Rubinsky,et al.  Electrical field and temperature model of nonthermal irreversible electroporation in heterogeneous tissues. , 2009, Journal of biomechanical engineering.

[17]  D Miklavcic,et al.  Efficiency of high- and low-voltage pulse combinations for gene electrotransfer in muscle, liver, tumor, and skin. , 2008, Human gene therapy.

[18]  Sergio Silvestri,et al.  EUS-guided Nd:YAG laser ablation of normal pancreatic tissue: a pilot study in a pig model. , 2010, Gastrointestinal endoscopy.

[19]  Boris Rubinsky,et al.  Tumor Ablation with Irreversible Electroporation , 2007, PloS one.

[20]  Boris Rubinsky,et al.  Optimal parameters for the destruction of prostate cancer using irreversible electroporation. , 2008, The Journal of urology.

[21]  M. Giovannini.  Concentration-dependent ablation of pancreatic tissue by EUS-guided ethanol injection. , 2007, Gastrointestinal endoscopy.

[22]  Raphael C. Lee,et al.  Cell Injury by Electric Forces , 2005, Annals of the New York Academy of Sciences.

[23]  José Juan Escobar-Chávez,et al.  Electroporation as an Efficient Physical Enhancer for Skin Drug Delivery , 2009, Journal of clinical pharmacology.

[24]  H. Mugishima,et al.  Application of radiofrequency ablation for giant solid pseudopapillary tumor of the pancreas , 2010, Pediatrics international : official journal of the Japan Pediatric Society.

[25]  Boris Rubinsky,et al.  Irreversible Electroporation: Implications for Prostate Ablation , 2007, Technology in cancer research & treatment.

[26]  Boris Rubinsky,et al.  Mass Transfer Model for Drug Delivery in Tissue Cells with Reversible Electroporation. , 2008, International journal of heat and mass transfer.

[27]  B. Rubinsky,et al.  Tissue Ablation with Irreversible Electroporation , 2005, Annals of Biomedical Engineering.