p76MDM2 Inhibits the Ability of p90MDM2to Destabilize p53*
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L. Saucedo | M. E. Perry | S. Mendrysa | S M Mendrysa | M E Perry | P. Tannous | L J Saucedo | P Tannous | M Holubar | Marisa Holubar
[1] A. Levine,et al. Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene , 1995, Molecular medicine.
[2] T. Tursz,et al. Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells , 1998, Oncogene.
[3] A. Levine,et al. The mdm-2 gene is induced in response to UV light in a p53-dependent manner. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[4] S. Mai,et al. Enhanced p53 activity and accumulation in response to DNA damage upon DNA transfection. , 1995, Oncogene.
[5] A. Levine,et al. Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes. , 1993, Oncogene.
[6] M. Oren,et al. Mdm2 promotes the rapid degradation of p53 , 1997, Nature.
[7] P. Meltzer,et al. Amplification of a gene encoding a p53-associated protein in human sarcomas , 1992, Nature.
[8] Ken Chen,et al. The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53 , 1998, Cell.
[9] C. Prives. Signaling to p53 Breaking the MDM2–p53 Circuit , 1998, Cell.
[10] A. Levine,et al. Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6 , 1998, Molecular and Cellular Biology.
[11] Guillermina Lozano,et al. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53 , 1995, Nature.
[12] A. Levine,et al. Nucleo‐cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein , 1998, The EMBO journal.
[13] R. Honda,et al. Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53 , 1999, The EMBO journal.
[14] L. Saucedo,et al. The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19ARF , 1999, Journal of Virology.
[15] J. Blaydes,et al. The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2 , 1998, Oncogene.
[16] D. Lane,et al. Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo. , 1995, Journal of cell science.
[17] A. Levine,et al. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation , 1992, Cell.
[18] C J Kemp,et al. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. , 1994, Cancer research.
[19] Hirofumi Tanaka,et al. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 , 1997, FEBS letters.
[20] P. Meltzer,et al. p53 Mutation and MDM2 amplification in human soft tissue sarcomas. , 1993, Cancer research.
[21] Yoichi Taya,et al. DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2 , 1997, Cell.
[22] W. Maltzman,et al. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells , 1984, Molecular and cellular biology.
[23] S. Lowe,et al. E1A signaling to p53 involves the p19(ARF) tumor suppressor. , 1998, Genes & development.
[24] J. Landers,et al. Physical and functional interaction between wild-type p53 and mdm2 proteins , 1994, Molecular and cellular biology.
[25] D. George,et al. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. , 1991, The EMBO journal.
[26] Lawrence A. Donehower,et al. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53 , 1995, Nature.
[27] Yue Xiong,et al. ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways , 1998, Cell.
[28] A. Levine,et al. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[29] B. Vogelstein,et al. p53 functions as a cell cycle control protein in osteosarcomas , 1990, Molecular and cellular biology.
[30] B. Vogelstein,et al. Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[31] M. Oren,et al. Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. , 1994, Genes & development.
[32] A. Levine,et al. P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[33] L. Saucedo,et al. Regulation of transcriptional activation of mdm2 gene by p53 in response to UV radiation. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[34] L. Saucedo,et al. Multiple Murine Double Minute Gene 2 (MDM2) Proteins Are Induced by Ultraviolet Light* , 1999, The Journal of Biological Chemistry.
[35] A. Balmain,et al. The p53 response to ionising radiation in adult and developing murine tissues. , 1996, Oncogene.
[36] A. Levine,et al. Mapping of the p53 and mdm-2 interaction domains. , 1993, Molecular and cellular biology.
[37] A. Levine,et al. p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts. , 1991, Genes & development.
[38] A. van der Eb,et al. A new technique for the assay of infectivity of human adenovirus 5 DNA. , 1973, Virology.
[39] A. Levine,et al. The p53-mdm-2 autoregulatory feedback loop. , 1993, Genes & development.
[40] A. Levine,et al. The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain , 1996, Molecular medicine.
[41] A. Levine,et al. Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines , 1987, Molecular and cellular biology.
[42] Bert Vogelstein,et al. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 , 1993, Nature.
[43] D. Livingston,et al. p300/MDM2 complexes participate in MDM2-mediated p53 degradation. , 1998, Molecular cell.
[44] D. Neal,et al. Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer , 1996, Nature Medicine.
[45] Stephen N. Jones,et al. Regulation of p53 stability by Mdm2 , 1997, Nature.
[46] M. Oren,et al. mdm2 expression is induced by wild type p53 activity. , 1993, The EMBO journal.