Chronically Maternal Exposure to Fenvalerate during Medium-Late Pregnancy Accelerated Cognitive Decline in Middle-Aged Offspring Mice

Epidemiological evidence suggests that pesticide exposure may be involved in the pathogenesis of Alzheimer's disease (AD). However, whether maternal exposure to fenvalerate (FV) can affect AD-type behaviors in middle-aged offspring has not been determined yet. In this study, CD-1 mothers received 7.5 mg/kg FV or corn oil by gavage daily during gestational days 8-18. Body weight of the offspring was recorded at ages 4-34 weeks. A battery of behavioral tasks was conducted at 13-month, and 5-month-old mice were set as a young control. The results showed that there was insignificant difference in body weight between the FV-treated and control mice. Compared to the young mice, the middle-aged control mice exhibited decreased burrowing activity, decreased spontaneous exploration and sensorimotor ability, increased anxiety, and impaired abilities of spatial and non-spatial learning and memory. Compared to the controls, the FV-treated mice exhibited similar species-typical behaviors, locomotor activity, sensorimotor abilities, but increased anxiety, and decreased abilities of learning and memory. Our results suggested that chronically maternal exposure to FV at a low dose in medium-late gestation could accelerate the impairment in the behaviors of learning and memory and anxiety in the middle-aged offspring, which experience a normal duration of development.

[1]  Rolf T Hansen,et al.  Senescent-induced dysregulation of cAMP/CREB signaling and correlations with cognitive decline , 2013, Brain Research.

[2]  L. V. Van Eldik,et al.  Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease , 2013, Alzheimer's Research & Therapy.

[3]  A. Tsatsakis,et al.  Linking pesticide exposure and dementia: what is the evidence? , 2013, Toxicology.

[4]  T. Haaf,et al.  Epigenetics of gestational diabetes mellitus and offspring health: the time for action is in early stages of life , 2013, Molecular human reproduction.

[5]  W. Thies,et al.  2013 Alzheimer's disease facts and figures , 2013, Alzheimer's & Dementia.

[6]  K. Bala,et al.  Organochlorine pesticide levels and risk of Alzheimer’s disease in north Indian population , 2013, Human & experimental toxicology.

[7]  K Steenland,et al.  Occupational pesticide exposure and screening tests for neurodegenerative disease among an elderly population in Costa Rica. , 2013, Environmental research.

[8]  S. Øverland,et al.  The fetal origins of adult disease: a narrative review of the epidemiological literature , 2012, JRSM short reports.

[9]  N. Zawia,et al.  Applying epigenetics to Alzheimer's disease via the latent early-life associated regulation (LEARn) model. , 2012, Current Alzheimer research.

[10]  H. Ning,et al.  [Effects of rat maternal fenvalerate exposure on behavior development of rat pubertal female offspring]. , 2012, Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.

[11]  Wei Yang,et al.  Air Pollution, Oxidative Stress, and Alzheimer's Disease , 2012, Journal of environmental and public health.

[12]  Qitao Ran,et al.  Cognitive impairment and increased Aβ levels induced by paraquat exposure are attenuated by enhanced removal of mitochondrial H2O2 , 2012, Neurobiology of Aging.

[13]  Yi Wang,et al.  Pesticides induce spatial memory deficits with synaptic impairments and an imbalanced tau phosphorylation in rats. , 2012, Journal of Alzheimer's disease : JAD.

[14]  Antonio F. Hernández,et al.  Association between environmental exposure to pesticides and neurodegenerative diseases. , 2011, Toxicology and applied pharmacology.

[15]  M. Ishido,et al.  Neurotoxicity of Endocrine Disruptors: Possible Involvement in Brain Development and Neurodegeneration , 2011, Journal of toxicology and environmental health. Part B, Critical reviews.

[16]  Hua Wang,et al.  Gender-specific impairments on cognitive and behavioral development in mice exposed to fenvalerate during puberty. , 2011, Toxicology letters.

[17]  Shauna M. Stark,et al.  Age-related memory deficits linked to circuit-specific disruptions in the hippocampus , 2011, Proceedings of the National Academy of Sciences.

[18]  Hua Wang,et al.  Acceleration of age-related learning and memory decline in middle-aged CD-1 mice due to maternal exposure to lipopolysaccharide during late pregnancy , 2011, Behavioural Brain Research.

[19]  E. Alleva,et al.  Early exposure to low doses of atrazine affects behavior in juvenile and adult CD1 mice. , 2011, Toxicology.

[20]  M. Skinner.  Fetal origins of adult disease , 2011 .

[21]  P. Hof,et al.  Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease , 2010, International journal of Alzheimer's disease.

[22]  K. Welsh-Bohmer,et al.  Occupational exposure to pesticides increases the risk of incident AD , 2010, Neurology.

[23]  E. Quertemont,et al.  Anxiety in adult female mice following perinatal exposure to chlorpyrifos. , 2010, Neurotoxicology and teratology.

[24]  W. Porter,et al.  Long-term sex selective hormonal and behavior alterations in mice exposed to low doses of chlorpyrifos in utero. , 2010, Reproductive toxicology.

[25]  T. Salthouse.  When does age-related cognitive decline begin? , 2009, Neurobiology of Aging.

[26]  E. M. Reyes-Reyes,et al.  Environmental toxicity, oxidative stress and apoptosis: ménage à trois. , 2009, Mutation research.

[27]  George Perry,et al.  Transgenic Mouse Models of Alzheimer’s Disease: Behavioral Testing and Considerations , 2009 .

[28]  L. Ricceri,et al.  Gestational exposure to the organophosphate chlorpyrifos alters social–emotional behaviour and impairs responsiveness to the serotonin transporter inhibitor fluvoxamine in mice , 2009, Psychopharmacology.

[29]  S. Michalikova,et al.  Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: Effects of low infrared light , 2008, Neurobiology of Learning and Memory.

[30]  A. Ennaceur,et al.  Detailed analysis of the behavior and memory performance of middle-aged male and female CD-1 mice in a 3D maze , 2008, Behavioural Brain Research.

[31]  J. Harrill,et al.  Neurobehavioral toxicology of pyrethroid insecticides in adult animals: a critical review. , 2008, Neurotoxicology and teratology.

[32]  Sanjay Yadav,et al.  Overexpression of cerebral and hepatic cytochrome P450s alters behavioral activity of rat offspring following prenatal exposure to lindane. , 2007, Toxicology and applied pharmacology.

[33]  E. Alleva,et al.  Spatial memory deficits in middle‐aged mice correlate with lower exploratory activity and a subordinate status: role of hippocampal neurotrophins , 2006, The European journal of neuroscience.

[34]  L. Whalley,et al.  A life-course approach to the aetiology of late-onset dementias , 2006, The Lancet Neurology.

[35]  M. Bernardi,et al.  Behavioral and endocrine changes induced by perinatal fenvalerate exposure in female rats. , 2005, Neurotoxicology and teratology.

[36]  R. Haimov-Kochman,et al.  [Fetal programming--the intrauterine origin of adult morbidity]. , 2005, Harefuah.

[37]  Ana Navarro,et al.  Behavioral dysfunction, brain oxidative stress, and impaired mitochondrial electron transfer in aging mice. , 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

[38]  Chopde Ct,et al.  Neurobehavioral effects of low level fenvalerate exposure in mice. , 1997 .

[39]  C. Chopde,et al.  Neurobehavioral effects of low level fenvalerate exposure in mice. , 1997, Indian journal of experimental biology.

[40]  Majeed Sk.  Survey on spontaneous systemic amyloidosis in aging mice. , 1993 .

[41]  S. K. Majeed.  Survey on spontaneous systemic amyloidosis in aging mice. , 1993, Arzneimittel-Forschung.