The transcriptome of human mammary epithelial cells infected with the HCMV-DB strain displays oncogenic traits

[1]  Amit Kumar,et al.  The Human Cytomegalovirus Strain DB Activates Oncogenic Pathways in Mammary Epithelial Cells , 2018, EBioMedicine.

[2]  P. Tomasec,et al.  The pentameric complex drives immunologically covert cell–cell transmission of wild-type human cytomegalovirus , 2017, Proceedings of the National Academy of Sciences.

[3]  J. Díaz-Chávez,et al.  Overexpression of p53 protein is a marker of poor prognosis in Mexican women with breast cancer. , 2017, Oncology reports.

[4]  R. Kalejta,et al.  Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins , 2017, The Journal of Biological Chemistry.

[5]  Haluk Resat,et al.  Constitutive activation of STAT3 in breast cancer cells: A review , 2016, International journal of cancer.

[6]  Zigang Dong,et al.  Implications of Genetic and Epigenetic Alterations of CDKN2A (p16INK4a) in Cancer , 2016, EBioMedicine.

[7]  T. Rebbeck,et al.  Distinct microbiological signatures associated with triple negative breast cancer , 2015, Scientific Reports.

[8]  M. Weekes,et al.  Human cytomegalovirus: taking the strain , 2015, Medical Microbiology and Immunology.

[9]  Brent J. Ryckman,et al.  A viral regulator of glycoprotein complexes contributes to human cytomegalovirus cell tropism , 2015, Proceedings of the National Academy of Sciences.

[10]  L. Castellano,et al.  Mammosphere formation assay from human breast cancer tissues and cell lines. , 2015, Journal of visualized experiments : JoVE.

[11]  R. Rappuoli,et al.  Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes , 2015, Proceedings of the National Academy of Sciences.

[12]  R. Büttner,et al.  c-myc copy number gain is a powerful prognosticator of disease outcome in cervical dysplasia , 2014, Oncotarget.

[13]  J. Joyce,et al.  Pericellular proteolysis in cancer , 2014, Genes & development.

[14]  M. Ando,et al.  Activated PI3K/AKT and MAPK pathways are potential good prognostic markers in node-positive, triple-negative breast cancer. , 2014, Annals of oncology : official journal of the European Society for Medical Oncology.

[15]  Amit Kumar,et al.  The Oncogenic Potential of Human Cytomegalovirus and Breast Cancer , 2014, Front. Oncol..

[16]  Yongchao Ge,et al.  Human Cytomegalovirus Modulates Monocyte-Mediated Innate Immune Responses during Short-Term Experimental Latency In Vitro , 2014, Journal of Virology.

[17]  S. Warming,et al.  Mechanism for neutralizing activity by the anti-CMV gH/gL monoclonal antibody MSL-109 , 2014, Proceedings of the National Academy of Sciences.

[18]  A. Krešo,et al.  Evolution of the cancer stem cell model. , 2014, Cell stem cell.

[19]  P. Maes,et al.  Genomic and Functional Characteristics of Human Cytomegalovirus Revealed by Next-Generation Sequencing , 2014, Viruses.

[20]  Gene W. Yeo,et al.  Human Cytomegalovirus Infection of Human Embryonic Stem Cell-Derived Primitive Neural Stem Cells Is Restricted at Several Steps but Leads to the Persistence of Viral DNA , 2014, Journal of Virology.

[21]  J. Zavadil,et al.  Global reprogramming of the cellular translational landscape facilitates cytomegalovirus replication. , 2014, Cell reports.

[22]  A. Brass,et al.  A Novel DDB2-ATM Feedback Loop Regulates Human Cytomegalovirus Replication , 2013, Journal of Virology.

[23]  Frederick S. Vizeacoumar,et al.  RB1 Status in Triple Negative Breast Cancer Cells Dictates Response to Radiation Treatment and Selective Therapeutic Drugs , 2013, PloS one.

[24]  D. Quail,et al.  Microenvironmental regulation of tumor progression and metastasis , 2014 .

[25]  J. Dopazo,et al.  Mammosphere Formation in Breast Carcinoma Cell Lines Depends upon Expression of E-cadherin , 2013, PloS one.

[26]  M. Sypabekova,et al.  Role of viruses in the development of breast cancer , 2013, Infectious Agents and Cancer.

[27]  J. Jensen,et al.  Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection , 2013, PLoS genetics.

[28]  Xiaoqiang Tang.  Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer. , 2013, Cancer letters.

[29]  Amit Kumar,et al.  HCMV Activates the IL-6-JAK-STAT3 Axis in HepG2 Cells and Primary Human Hepatocytes , 2013, PloS one.

[30]  J. Hartman,et al.  High Prevalence of Human Cytomegalovirus Proteins and Nucleic Acids in Primary Breast Cancer and Metastatic Sentinel Lymph Nodes , 2013, PloS one.

[31]  M. L. Simpson,et al.  An Endogenous Accelerator for Viral Gene Expression Confers a Fitness Advantage , 2012, Cell.

[32]  Peter Kraft,et al.  Prediction of breast cancer risk by genetic risk factors, overall and by hormone receptor status , 2012, Journal of Medical Genetics.

[33]  Karin Jirström,et al.  The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients , 2012, BMC Cancer.

[34]  T. Kowalik,et al.  Genetic Analysis of Cytomegalovirus in Malignant Gliomas , 2012, Journal of Virology.

[35]  M. Szyf.  DNA methylation signatures for breast cancer classification and prognosis , 2012, Genome Medicine.

[36]  C. Cobbs,et al.  Human cytomegalovirus US28 found in glioblastoma promotes an invasive and angiogenic phenotype. , 2011, Cancer research.

[37]  P. Siesjö,et al.  Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target. , 2011, The Journal of clinical investigation.

[38]  A. Asplund,et al.  High-Risk HPV Infection and CIN Grade Correlates to the Expression of c-myc, CD4+, FHIT, E-cadherin, Ki-67, and p16INK4a , 2011, Journal of lower genital tract disease.

[39]  X. Chen,et al.  Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. , 2011, The Journal of clinical investigation.

[40]  G. Herbein,et al.  Cytomegalovirus and Tumors: Two Players for One Goal-Immune Escape , 2011, The open virology journal.

[41]  Nicholas B. Levine,et al.  Glioma-Associated Cytomegalovirus Mediates Subversion of the Monocyte Lineage to a Tumor Propagating Phenotype , 2011, Clinical Cancer Research.

[42]  C. Cobbs,et al.  Detection of human cytomegalovirus in normal and neoplastic breast epithelium , 2010, Herpesviridae.

[43]  F. Dalenc,et al.  Manipulating Protein Acetylation in Breast Cancer: A Promising Approach in Combination with Hormonal Therapies? , 2010, Journal of biomedicine & biotechnology.

[44]  T. Shenk,et al.  Experimental human cytomegalovirus latency in CD14+ monocytes , 2010, Proceedings of the National Academy of Sciences.

[45]  E. Molloy,et al.  Human Cytomegalovirus UL144 Is Associated with Viremia and Infant Development Sequelae in Congenital Infection , 2010, Journal of Clinical Microbiology.

[46]  Marco Siderius,et al.  HCMV-Encoded Chemokine Receptor US28 Mediates Proliferative Signaling Through the IL-6–STAT3 Axis , 2010, Science Signaling.

[47]  Johan Staaf,et al.  Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns , 2010, Breast Cancer Research.

[48]  M. Karin,et al.  Immunity, Inflammation, and Cancer , 2010, Cell.

[49]  P. Griffiths,et al.  Sequences of complete human cytomegalovirus genomes from infected cell cultures and clinical specimens , 2010, The Journal of general virology.

[50]  G. Chan,et al.  Activation of EGFR on monocytes is required for human cytomegalovirus entry and mediates cellular motility , 2009, Proceedings of the National Academy of Sciences.

[51]  M. Jarvis,et al.  A Human Cytomegalovirus gO-Null Mutant Fails To Incorporate gH/gL into the Virion Envelope and Is Unable To Enter Fibroblasts and Epithelial and Endothelial Cells , 2009, Journal of Virology.

[52]  Shang-Kwei Wang,et al.  Human cytomegalovirus UL76 induces chromosome aberrations , 2009, Journal of Biomedical Science.

[53]  K. Khan,et al.  Bcl-3-Regulated Transcription from Major Immediate-Early Promoter of Human Cytomegalovirus in Monocyte-Derived Macrophages1 , 2009, The Journal of Immunology.

[54]  K. Chin,et al.  Protein Acetylation and Histone Deacetylase Expression Associated with Malignant Breast Cancer Progression , 2009, Clinical Cancer Research.

[55]  S. Kyo,et al.  Activation of telomerase by human cytomegalovirus. , 2009, Journal of the National Cancer Institute.

[56]  Holger Hannemann,et al.  The Presence of p53 Influences the Expression of Multiple Human Cytomegalovirus Genes at Early Times Postinfection , 2009, Journal of Virology.

[57]  Brent J. Ryckman,et al.  HCMV gH/gL/UL128–131 interferes with virus entry into epithelial cells: Evidence for cell type-specific receptors , 2008, Proceedings of the National Academy of Sciences.

[58]  D. Coen,et al.  Phosphorylation of Retinoblastoma Protein by Viral Protein with Cyclin-Dependent Kinase Function , 2008, Science.

[59]  C. Söderberg-Nauclér,et al.  Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer? , 2006, Journal of internal medicine.

[60]  Brent J. Ryckman,et al.  Human Cytomegalovirus Entry into Epithelial and Endothelial Cells Depends on Genes UL128 to UL150 and Occurs by Endocytosis and Low-pH Fusion , 2006, Journal of Virology.

[61]  Alan Cantor,et al.  Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression , 2006, Clinical Cancer Research.

[62]  T. Shenk,et al.  Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[63]  J. Testa,et al.  Perturbations of the AKT signaling pathway in human cancer , 2005, Oncogene.

[64]  H. A. Rogoff,et al.  Human Cytomegalovirus IE1-72 Activates Ataxia Telangiectasia Mutated Kinase and a p53/p21-Mediated Growth Arrest Response , 2005, Journal of Virology.

[65]  Noriko Shirata,et al.  Activation of Ataxia Telangiectasia-mutated DNA Damage Checkpoint Signal Transduction Elicited by Herpes Simplex Virus Infection* , 2005, Journal of Biological Chemistry.

[66]  Goberdhan P Dimri,et al.  Mammary epithelial cell transformation: insights from cell culture and mouse models , 2005, Breast Cancer Research.

[67]  A. Varin,et al.  Mixed cytomegalovirus glycoprotein B genotypes in immunocompromised patients. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[68]  L. Juan,et al.  HCMV IE2‐mediated inhibition of HAT activity downregulates p53 function , 2004, The EMBO journal.

[69]  J. Alexander,et al.  Human Cytomegalovirus Induces Monocyte Differentiation and Migration as a Strategy for Dissemination and Persistence , 2004, Journal of Virology.

[70]  M. Abba,et al.  The c-myc activation in cervical carcinomas and HPV 16 infections. , 2004, Mutation research.

[71]  R. Eeles,et al.  ATM protein overexpression in prostate tumors: possible role in telomere maintenance. , 2004, American journal of clinical pathology.

[72]  R. Myers,et al.  Coding potential of laboratory and clinical strains of human cytomegalovirus , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[73]  C. Cobbs,et al.  High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma. , 2003, The Journal of urology.

[74]  W. Hahn,et al.  Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. , 2003, Cancer cell.

[75]  T. Shenk,et al.  Human Cytomegalovirus pp71 Stimulates Cell Cycle Progression by Inducing the Proteasome-Dependent Degradation of the Retinoblastoma Family of Tumor Suppressors , 2003, Molecular and Cellular Biology.

[76]  D. Galloway,et al.  Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins. , 2003, Carcinogenesis.

[77]  C. Cobbs,et al.  Human cytomegalovirus infection and expression in human malignant glioma. , 2002, Cancer research.

[78]  W. Hahn,et al.  Telomerase activation, cellular immortalization and cancer , 2001, Annals of medicine.

[79]  M. Dell'aquila,et al.  Specific chromosome 1 breaks induced by human cytomegalovirus. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[80]  C. López-Otín,et al.  Breast and prostate cancer: an analysis of common epidemiological, genetic, and biochemical features. , 1998, Endocrine reviews.

[81]  F. Hufert,et al.  Glycoprotein B genotype correlates with cell tropism in vivo of human cytomegalovirus infection , 1998, Journal of medical virology.

[82]  D. Dittmer,et al.  Human cytomegalovirus infection inhibits G1/S transition , 1997, Journal of virology.

[83]  J. Sinclair,et al.  The 72K IE1 and 80K IE2 proteins of human cytomegalovirus independently trans-activate the c-fos, c-myc and hsp70 promoters via basal promoter elements. , 1992, The Journal of general virology.

[84]  T. Albrecht,et al.  Transcriptional activation of cellular oncogenes fos, jun, and myc by human cytomegalovirus , 1991, Journal of virology.

[85]  T. Albrecht,et al.  Activation of proto-oncogenes: an immediate early event in human cytomegalovirus infection. , 1990, Science.

[86]  C. Stace,et al.  Where and why? , 1988, Nature.

[87]  C Tuffnell,et al.  Taking the strain. , 1987, The New Zealand nursing journal. Kai tiaki.

[88]  F. Rapp,et al.  Oncogenic transformation of human embryo lung cells by human cytomegalovirus. , 1976, Science.

[89]  E. Yuliwati,et al.  A Review , 2019, Current Trends and Future Developments on (Bio-) Membranes.

[90]  H. Doerr,et al.  The story of human cytomegalovirus and cancer: increasing evidence and open questions. , 2009, Neoplasia.

[91]  H. zur Hausen,et al.  The search for infectious causes of human cancers: where and why. , 2009, Virology.

[92]  W. Hahn,et al.  Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. , 2001, Genes & development.