Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling.
暂无分享,去创建一个
[1] Stephen C Kales,et al. Cbl and human myeloid neoplasms: the Cbl oncogene comes of age. , 2010, Cancer research.
[2] Charles P. Lin,et al. Bone progenitor dysfunction induces myelodysplasia and secondary leukemia , 2010, Nature.
[3] S. Ogawa,et al. Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms , 2010, Cell cycle.
[4] A. Jankowska,et al. Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia. , 2010, Blood.
[5] C. Scott,et al. c-Cbl Promotes T Cell Receptor-induced Thymocyte Apoptosis by Activating the Phosphatidylinositol 3-Kinase/Akt Pathway* , 2010, The Journal of Biological Chemistry.
[6] Ravi Salgia,et al. CBL Is Frequently Altered in Lung Cancers: Its Relationship to Mutations in MET and EGFR Tyrosine Kinases , 2010, PloS one.
[7] M. McDevitt,et al. Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[8] J. Duyster,et al. E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease. , 2009, Blood.
[9] C. O'keefe,et al. Application of array‐based whole genome scanning technologies as a cytogenetic tool in haematological malignancies , 2009, British journal of haematology.
[10] M. Loh,et al. Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. , 2009, Blood.
[11] S. Ogawa,et al. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms , 2009, Nature.
[12] W. Hiddemann,et al. CBL Exon 8/9 Mutants Activate the FLT3 Pathway and Cluster in Core Binding Factor/11q Deletion Acute Myeloid Leukemia/Myelodysplastic Syndrome Subtypes , 2009, Clinical Cancer Research.
[13] A. Hall,et al. Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. , 2008, Blood.
[14] R. Arceci. PML targeting eradicates quiescent leukaemia-initiating cells , 2009 .
[15] M. McDevitt,et al. 250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies. , 2008, Cancer research.
[16] R. Salgia,et al. Novel Transforming Mutations of CBL in Human Acute Myeloid Leukemia , 2008 .
[17] S. Ogawa,et al. Genome-Wide Analysis of MDS/MPD Disclosed Frequent Homozygous C-Cbl mutations Tightly Associated with 11q-UPD , 2008 .
[18] B. Löwenberg,et al. Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias , 2008, Haematologica.
[19] P. Aplan,et al. Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl. , 2008, Blood.
[20] R. Flavell,et al. The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells. , 2008, Genes & development.
[21] E. Dzierzak,et al. Fine-tuning of hematopoietic stem cell homeostasis: novel role for ubiquitin ligase. , 2008, Genes & development.
[22] M. Oksvold,et al. The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgE-activated mast cells. , 2008, Molecular immunology.
[23] M. Caligiuri,et al. Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia. , 2007, Blood.
[24] Chunaram Choudhary,et al. Flt3-dependent transformation by inactivating c-Cbl mutations in AML. , 2007, Blood.
[25] P. Chambon,et al. A Microenvironment-Induced Myeloproliferative Syndrome Caused by Retinoic Acid Receptor γ Deficiency , 2007, Cell.
[26] Christian Steidl,et al. Essential role of Jun family transcription factors in PU.1 knockdown–induced leukemic stem cells , 2006, Nature Genetics.
[27] T. Owaidah,et al. Cytogenetics, molecular and ultrastructural characteristics of biphenotypic acute leukemia identified by the EGIL scoring system , 2006, Leukemia.
[28] Ivan Dikic,et al. The Cbl interactome and its functions , 2005, Nature Reviews Molecular Cell Biology.
[29] W. Langdon,et al. Loss of c‐Cbl RING finger function results in high‐intensity TCR signaling and thymic deletion , 2005, The EMBO journal.
[30] W. Langdon,et al. c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses. , 2005, The Biochemical journal.
[31] J. Dick,et al. Cancer stem cells: lessons from leukemia. , 2005, Trends in cell biology.
[32] D. Bonnet. Normal and leukaemic stem cells , 2005, British journal of haematology.
[33] S. E. Jacobsen,et al. Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients. , 2005, Blood.
[34] I. Weissman,et al. JunB Deficiency Leads to a Myeloproliferative Disorder Arising from Hematopoietic Stem Cells , 2004, Cell.
[35] J. Radich,et al. The role of FLT3 in haematopoietic malignancies , 2003, Nature Reviews Cancer.
[36] D. Bowtell,et al. A Mouse with a Loss-of-function Mutation in the c-Cbl TKB Domain Shows Perturbed Thymocyte Signaling without Enhancing the Activity of the ZAP-70 Tyrosine Kinase , 2003, The Journal of experimental medicine.
[37] F. Walker,et al. RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation. , 2001, Molecular cell.
[38] Ping Wang,et al. Structure of a c-Cbl–UbcH7 Complex RING Domain Function in Ubiquitin-Protein Ligases , 2000, Cell.
[39] B. Pulendran,et al. Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. , 2000, Blood.
[40] H. Nishina,et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b , 2000, Nature.
[41] A Ciechanover,et al. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. , 1999, Molecular cell.
[42] T. Hunter,et al. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. , 1999, Science.
[43] M. Naramura,et al. Altered thymic positive selection and intracellular signals in Cbl-deficient mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[44] D. Bowtell,et al. Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice , 1998, Molecular and Cellular Biology.
[45] S. Orkin,et al. The transcriptional control of hematopoiesis. , 1996, Blood.
[46] P. Sternberg,et al. Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl , 1995, Science.
[47] M. Caligiuri,et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice , 1994, Nature.
[48] S. Klinken,et al. v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. , 1989, Proceedings of the National Academy of Sciences of the United States of America.