Problems of somatic mutation and cancer.

Somatic mutation plays a key role in transforming normal cells into cancerous cells. The analysis of cancer progression therefore requires the study of how point mutations and chromosomal mutations accumulate in cellular lineages. The spread of somatic mutations depends on the mutation rate, the number of cell divisions in the history of a cellular lineage, and the nature of competition between different cellular lineages. We consider how various aspects of tissue architecture and cellular competition affect the pace of mutation accumulation. We also discuss the rise and fall of somatic mutation rates during cancer progression.

[1]  M. Delbrück,et al.  Mutations of Bacteria from Virus Sensitivity to Virus Resistance. , 1943, Genetics.

[2]  P. Armitage,et al.  A Two-stage Theory of Carcinogenesis in Relation to the Age Distribution of Human Cancer , 1957, British Journal of Cancer.

[3]  J. C. FISHER,et al.  Multiple-Mutation Theory of Carcinogenesis , 1958, Nature.

[4]  B. Mintz Clonal basis of mammalian differentiation. , 1971, Symposia of the Society for Experimental Biology.

[5]  John Cairns,et al.  Mutation selection and the natural history of cancer , 1975, Nature.

[6]  P. Nowell The clonal evolution of tumor cell populations. , 1976, Science.

[7]  M. Eigen,et al.  The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle. , 1977, Die Naturwissenschaften.

[8]  A. Knudson,et al.  Model for the incidence of embryonal cancers: application to retinoblastoma. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[9]  M. Eigen,et al.  Emergence of the Hypercycle , 1979 .

[10]  M. Eigen,et al.  The Hypercycle: A principle of natural self-organization , 2009 .

[11]  John Maynard Smith,et al.  Hypercycles and the origin of life , 1979, Nature.

[12]  H. Outzen Development of carcinogen‐induced skin tumors in mice with varied states of immune capacity , 1980, International journal of cancer.

[13]  L. Buss,et al.  The evolution of individuality , 1987 .

[14]  B. Ponder,et al.  Development of the pattern of cell renewal in the crypt-villus unit of chimaeric mouse small intestine. , 1988, Development.

[15]  L. Loeb,et al.  Mutator phenotype may be required for multistage carcinogenesis. , 1991, Cancer research.

[16]  S. Yuspa,et al.  A model for initiated mouse skin: suppression of papilloma but not carcinoma formation by normal epidermal cells in grafts on athymic nude mice. , 1992, Cancer research.

[17]  A. Knudson,et al.  Antioncogenes and human cancer. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[18]  M. Loeffler,et al.  Somatic mutation, monoclonality and stochastic models of stem cell organization in the intestinal crypt. , 1993, Journal of theoretical biology.

[19]  R T Prehn,et al.  Cancers beget mutations versus mutations beget cancers. , 1994, Cancer research.

[20]  R T Prehn,et al.  Stimulatory effects of immune reactions upon the growths of untransplanted tumors. , 1994, Cancer research.

[21]  Eörs Szathmáry,et al.  The Major Transitions in Evolution , 1997 .

[22]  Steven A. Frank,et al.  Models of Parasite Virulence , 1996, The Quarterly Review of Biology.

[23]  W F Bodmer,et al.  The mutation rate and cancer. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[24]  K. Kinzler,et al.  The Genetic Basis of Human Cancer , 1997 .

[25]  K. Kinzler,et al.  Genetic instability in colorectal cancers , 1997, Nature.

[26]  F M Watt,et al.  Epidermal stem cells: markers, patterning and the control of stem cell fate. , 1998, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[27]  B. Strauss,et al.  Hypermutability in carcinogenesis. , 1998, Genetics.

[28]  C. Potten,et al.  Stem cells in gastrointestinal epithelium: numbers, characteristics and death. , 1998, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[29]  L. Loeb,et al.  Cancer cells exhibit a mutator phenotype. , 1998, Advances in cancer research.

[30]  E. Li,et al.  Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases , 1998, Nature Genetics.

[31]  J. Cairns Mutation and cancer: the antecedents to our studies of adaptive mutation. , 1998, Genetics.

[32]  J. Herman,et al.  p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing. , 1999, Blood.

[33]  R. Prehn On the prevention and therapy of prostate cancer by androgen administration. , 1999, Cancer research.

[34]  G. Gaudernack,et al.  Genomic instability, DNA methylation, and natural selection in colorectal carcinogenesis. , 1999, Seminars in cancer biology.

[35]  Q Zheng,et al.  Progress of a half century in the study of the Luria-Delbrück distribution. , 1999, Mathematical biosciences.

[36]  K. Robertson,et al.  The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. , 1999, Nucleic acids research.

[37]  L. Nunney,et al.  Lineage selection and the evolution of multistage carcinogenesis , 1999, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[38]  E. Blackburn,et al.  Telomere states and cell fates , 2000, Nature.

[39]  J. Herman,et al.  Methylation Patterns of the E-cadherin 5′ CpG Island Are Unstable and Reflect the Dynamic, Heterogeneous Loss of E-cadherin Expression during Metastatic Progression* , 2000, The Journal of Biological Chemistry.

[40]  T. Johnson,et al.  The evolution of mutation rates: separating causes from consequences , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.

[41]  John N. Hutchinson,et al.  Transgenic mouse models of human breast cancer , 2000, Oncogene.

[42]  C. Potten,et al.  Stem cells: the intestinal stem cell as a paradigm. , 2000, Carcinogenesis.

[43]  R. DePinho,et al.  Mice without telomerase: what can they teach us about human cancer? , 2000, Nature Medicine.

[44]  S. Tavaré,et al.  Investigating stem cells in human colon by using methylation patterns , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[45]  F. Taddei,et al.  The rise and fall of mutator bacteria. , 2001, Current opinion in microbiology.

[46]  H. Rubin The role of selection in progressive neoplastic transformation. , 2001, Advances in cancer research.

[47]  C. Allis,et al.  Translating the Histone Code , 2001, Science.

[48]  A. Fabiato,et al.  Anonymity of reviewers , 1994 .

[49]  Peter A. Jones,et al.  The fundamental role of epigenetic events in cancer , 2002, Nature Reviews Genetics.

[50]  J. Sherley,et al.  Cosegregation of chromosomes containing immortal DNA strands in cells that cycle with asymmetric stem cell kinetics. , 2002, Cancer research.

[51]  J. D. de Visser The fate of microbial mutators. , 2002, Microbiology.

[52]  N. Wright,et al.  Gastrointestinal stem cells , 2002, The Journal of pathology.

[53]  C. Hutter,et al.  Epidermal stem cells , 2002, The Journal of pathology.

[54]  J. Cairns Somatic stem cells and the kinetics of mutagenesis and carcinogenesis , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[55]  Christopher S Potten,et al.  Intestinal stem cells protect their genome by selective segregation of template DNA strands. , 2002, Journal of cell science.

[56]  J. G. D. Visser,et al.  The fate of microbial mutators. , 2002 .

[57]  R. DePinho,et al.  Constitutive telomerase expression promotes mammary carcinomas in aging mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[58]  Robert A. Weinberg,et al.  Telomerase contributes to tumorigenesis by a telomere length-independent mechanism , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[59]  Christopher S Potten,et al.  The intestinal epithelial stem cell. , 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.

[60]  Rachel Jones,et al.  Behavioural genetics: Worms gang up on bacteria , 2002, Nature Reviews Neuroscience.

[61]  H. Herweijer,et al.  Progress and prospects: naked DNA gene transfer and therapy , 2003, Gene Therapy.

[62]  Steven A Frank,et al.  Stochastic elimination of cancer cells , 2003, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[63]  Martin A. Nowak,et al.  Cell biology: Developmental predisposition to cancer , 2003, Nature.

[64]  M. Nowak,et al.  Local Regulation of Homeostasis Favors Chromosomal Instability , 2003, Current Biology.

[65]  L. Nunney The population genetics of multistage carcinogenesis , 2003, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[66]  S. Frank Somatic Mutation: Early Cancer Steps Depend on Tissue Architecture , 2003, Current Biology.

[67]  Peter Schuster,et al.  A principle of natural self-organization , 1977, Naturwissenschaften.

[68]  M. Eigen Selforganization of matter and the evolution of biological macromolecules , 1971, Naturwissenschaften.