Research on polyvinylidene fluoride (PVDF) hollow-fiber hemodialyzer

Abstract In this study, polyvinylidene fluoride (PVDF) hollow-fiber hemodialysis membranes were prepared by non-solvent-induced phase separation. The PVDF hollow-fiber hemodialyzers were prepared by centrifugal casting. The results showed that the PVDF membrane had better mechanical and separation properties when the membrane wall thickness was 40 μm and the N,N-dimethylacetamide in the core was 70 Vol%. Compared with commercial polysulfone hemodialysis membrane (Fresenius F60S membrane), the PVDF membrane had better mechanical property and ultrafiltration (UF) flux of pure water. The PVDF dialyzer’s removal efficiency for middle molecules was proven to be much higher than that of the F60S dialyzer. The UF coefficient of a high-flux PVDF dialyzer is 62.6 ml/h/mm Hg, whereas F60S is 42.5 ml/h/mm Hg, which can promote clearance for middle molecules.

[1]  Antonio Comite,et al.  Novel porous poly (vinylidene fluoride) membranes for membrane distillation , 2005 .

[2]  M. Nomizu,et al.  Blood compatible aspects of DNA-modified polysulfone membrane-protein adsorption and platelet adhesion. , 2003, Biomaterials.

[3]  R. Fumero,et al.  Clinical Evaluation of Internal Hemodiafiltration (iHDF): A Diffusive-Convective Technique Performed with Internal Filtration Enhanced High-Flux Dialyzers , 2004, International Journal of Artificial Organs.

[4]  W. Clark,et al.  A New Method to Evaluate the Local Clearance at Different Annular Rings Inside Hemodialyzers , 2003, ASAIO journal (1992).

[5]  C Ronco,et al.  Impact of Spacing Filaments External to Hollow Fibers on Dialysate flow Distribution and Dialyzer Performance , 1997, The International journal of artificial organs.

[6]  Chong Cheng,et al.  Modification of polyethersulfone hemodialysis membrane by blending citric acid grafted polyurethane and its anticoagulant activity , 2012 .

[7]  Hyung-Keun Lee,et al.  Absorption of nitrogen dioxide by PVDF hollow fiber membranes in a G–L contactor , 2009 .

[8]  A. Richert,et al.  Vascular endothelial cell responses to different electrically charged poly(vinylidene fluoride) supports under static and oscillating flow conditions. , 1997, Biomaterials.

[9]  Mohamed Khayet,et al.  Characterization of membranes for membrane distillation by atomic force microscopy and estimation of their water vapor transfer coefficients in vacuum membrane distillation process , 2004 .

[10]  T. Meyer,et al.  Increasing the clearance of protein-bound solutes by addition of a sorbent to the dialysate. , 2007, Journal of the American Society of Nephrology : JASN.

[11]  A. Cheung,et al.  Increases in mass transfer-area coefficients and urea Kt/V with increasing dialysate flow rate are greater for high-flux dialyzers. , 2001, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[12]  W. Clark,et al.  Effect of flow baffles on the dialysate flow distribution of hollow-fiber hemodialyzers: a nonintrusive experimental study using MRI. , 2003, Journal of biomechanical engineering.

[13]  X. Tan,et al.  Polyvinylidene fluoride (PVDF) hollow fibre membranes for ammonia removal from water , 2006 .

[14]  F. Ran,et al.  Biocompatibility of modified polyethersulfone membranes by blending an amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone). , 2011, Acta biomaterialia.

[15]  T. Meyer,et al.  Increasing dialysate flow and dialyzer mass transfer area coefficient to increase the clearance of protein-bound solutes. , 2004, Journal of the American Society of Nephrology : JASN.

[16]  Qinglei Zhang,et al.  Preparation of Polyvinylidene Fluoride (PVDF) Hollow Fiber Hemodialysis Membranes , 2014, Membranes.

[17]  S. Chae,et al.  Comparison of fouling characteristics of two different poly-vinylidene fluoride microfiltration membranes in a pilot-scale drinking water treatment system using pre-coagulation/sedimentation, sand filtration, and chlorination. , 2008, Water research.

[18]  T. Liu,et al.  An evaluation of a polyethersulfone hollow fiber plasma separator by animal experiment. , 2001, Artificial organs.

[19]  J T Daugirdas,et al.  Hemodialyzer mass transfer-area coefficients for urea increase at high dialysate flow rates. The Hemodialysis (HEMO) Study. , 1997, Kidney international.

[20]  S. Kadam,et al.  The biocompatibility and separation performance of antioxidative polysulfone/vitamin E TPGS composite hollow fiber membranes. , 2011, Biomaterials.

[21]  N. Hoenich,et al.  The influence of the dialysate flow rate on hollow fiber hemodialyzer performance. , 1995, Artificial organs.

[22]  J. Watanabe,et al.  Protein adsorption-resistant hollow fibers for blood purification. , 2002, Artificial organs.

[23]  T. Obata,et al.  Detection of small degree of nonuniformity in dialysate flow in hollow-fiber dialyzer using proton magnetic resonance imaging. , 2004, Magnetic resonance imaging.