Nod‐like receptors are critical for gut–brain axis signalling in mice

•Nucleotide binding oligomerization domain (Nod)‐like receptors regulate cognition, anxiety and hypothalamic–pituitary–adrenal axis activation. •Nod‐like receptors regulate central and peripheral serotonergic biology. •Nod‐like receptors are important for maintenance of gastrointestinal physiology. •Intestinal epithelial cell expression of Nod1 receptors regulate behaviour.

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