论文信息 - COMPARATIVE ACTIVITIES OF MALEYL, FUMARYL, AND SUCCINYL DICHOLINE. A CORRECTION OF THE LITERATURE.

COMPARATIVE ACTIVITIES OF MALEYL, FUMARYL, AND SUCCINYL DICHOLINE. A CORRECTION OF THE LITERATURE.

Abstract A reinvestigation of the synthesis and structure of “dicholine maleate” reported by an earlier worker has shown that the cis ‐double bond was isomerized to the trans ‐form. An alternate synthesis for dicholine maleate has been repeated and has been found to give rise to the correct structure. Contrary to literature reports, there are marked differences in biological potency between maleyl and fumaryl dicholines compared with succinyl dicholine.

J. Cannon | J. Buckley | J. F. Mccarthy

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