Effect of microstructure on blood cell clogging in blood separators based on capillary action

In this study, the blood cell clogging phenomenon occurring in blood separators based on capillary action is carefully investigated and how to minimize the reduction in plasma separation speed caused by clogging is discussed. Four different blood separators are fabricated on optically transparent glass substrates to clearly observe the blood plasma separation and the blood cell clogging in the microfluidic devices. Each separation experiment is captured by a high-speed video camera. The captured images are analyzed using a theoretical model proposed in this study to quantify the effect of the microstructure on the degree of blood cell clogging. Finally, design guidelines for the microstructure of the micro blood separator are discussed based on the analysis.

[1]  C. Blattert,et al.  Microfluidic blood/plasma separation unit based on microchannel bend structures , 2005, 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology.

[2]  Y. Fung,et al.  Biomechanics: Mechanical Properties of Living Tissues , 1981 .

[3]  S. Son,et al.  Separation of blood cells and plasma in microchannel , 2005, The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05..

[4]  T. Crowley,et al.  Isolation of plasma from whole blood using planar microfilters for lab-on-a-chip applications. , 2005, Lab on a chip.

[5]  Jungyoup Han,et al.  An on-chip blood serum separator using self-assembled silica microsphere filter , 2005, The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05..

[6]  S C White,et al.  Alterations of the trabecular pattern of the jaws in patients with osteoporosis. , 1999, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[7]  A Flow-Through Shear-Type Microfilter Chip For Separating Plasma and Virus Particles from Whole Blood , 2004 .