The invention discloses a reactive intelligent control method for a power grid based on sensitivity and multiple Agents in the technical field of reactive voltage control of the power grid. The method comprises the following steps of: dividing transformer substations in the power grid into three levels according to the size of busbar voltages; dividing the power grid into multiple regions which do not intersected with one another, and dividing each region into multiple areas which are not intersected with one another; setting a region-level Agent for each region, and setting an area-level Agent for each area; respectively calculating region power grid voltage/reactive sensitivity matrixes and area power grid voltage/reactive sensitivity matrixes for the region-level Agents and the area-level Agents according to basic data collected by a dispatching center; carrying out region reactive voltage control on the region-class Agents according to the region power grid voltage/reactive sensitivity matrixes; and carrying out area reactive voltage control on the area-class Agents according to the area power grid voltage/reactive sensitivity matrixes. According to the reactive intelligent control method, the defect of large calculated amount in the conventional method is overcome by utilizing a sensitivity linear calculation method.