New approach to the synthesis of beta-2'-deoxyribonucleosides: Intramolecular Vorbrueggen coupling

Silylation of an O 2 ,5'-linked nucleoside follows by treatment with trimethylsilyl triflate affords an O 2 ,5'-anhydro nucleoside and its hydrolysis product the β-anomer of 2'-deoxyuridine in good yield in the first example of an oxygen-bridged intramolecular Vorbruggen coupling