A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels
暂无分享,去创建一个
[1] R. Vennekens,et al. TRPM5 in the battle against diabetes and obesity , 2018, Acta physiologica.
[2] P. Rorsman,et al. Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity , 2017, Nature Communications.
[3] A. Bassoli,et al. Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception , 2015, Molecules.
[4] C. Lindsley,et al. Development and validation of a thallium flux-based functional assay for the sodium channel NaV1.7 and its utility for lead discovery and compound profiling. , 2015, ACS chemical neuroscience.
[5] E. Wilmot,et al. Early onset type 2 diabetes: risk factors, clinical impact and management , 2014, Therapeutic advances in chronic disease.
[6] J. Parys,et al. Differential effects of bitter compounds on the taste transduction channels TRPM5 and IP3 receptor type 3. , 2014, Chemical senses.
[7] C. D. Del Negro,et al. The TRPM4 channel inhibitor 9‐phenanthrol , 2014, British journal of pharmacology.
[8] Bernd Nilius,et al. Mammalian Transient Receptor Potential (TRP) Cation Channels , 2014, Handbook of Experimental Pharmacology.
[9] Be'eri Niego,et al. Improved method for the preparation of a human cell-based, contact model of the blood-brain barrier. , 2013, Journal of visualized experiments : JoVE.
[10] S. Trivedi,et al. Novel Methodology to Identify TRPV1 Antagonists Independent of Capsaicin Activation , 2013, Journal of biomolecular screening.
[11] C. D. Del Negro,et al. Flufenamic acid as an ion channel modulator. , 2013, Pharmacology & therapeutics.
[12] D. Strøbæk,et al. A high-throughput screening campaign for detection of ca(2+)-activated k(+) channel activators and inhibitors using a fluorometric imaging plate reader-based tl(+)-influx assay. , 2013, Assay and drug development technologies.
[13] C. Weaver,et al. High-throughput screening for small-molecule modulators of inward rectifier potassium channels. , 2013, Journal of visualized experiments : JoVE.
[14] J. Shapiro,et al. Promising therapies for treating and/or preventing androgenic alopecia. , 2012, Skin therapy letter.
[15] Eric Schulze-Bahr,et al. Mutational spectrum in the Ca2+‐activated cation channel gene TRPM4 in patients with cardiac conductance disturbances , 2012, Human mutation.
[16] R. Vennekens,et al. The Ca 2+-Activated Monovalent Cation-Selective Channels TRPM4 and TRPM5 , 2012 .
[17] Hongzhen Hu,et al. Cell-based calcium assay for medium to high throughput screening of TRP channel functions using FlexStation 3. , 2011, Journal of visualized experiments : JoVE.
[18] Melissa R. Miller,et al. High-Throughput Screening of TRPC Channel Ligands Using Cell-Based Assays , 2011 .
[19] R. Cortés,et al. Triphenylphosphine oxide is a potent and selective inhibitor of the transient receptor potential melastatin-5 ion channel. , 2010, Assay and drug development technologies.
[20] R. Penner,et al. Development and Optimization of a High-Throughput Bioassay for TRPM7 Ion Channel Inhibitors , 2010, Journal of biomolecular screening.
[21] Xiaodong Li,et al. Molecular mechanism of the sweet taste enhancers , 2010, Proceedings of the National Academy of Sciences.
[22] K. Lemaire,et al. Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5−/− mice , 2010, Proceedings of the National Academy of Sciences.
[23] E. Schulze-Bahr,et al. Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I. , 2009, Journal of Clinical Investigation.
[24] Daniel Steiger,et al. Functional assessment of temperature-gated ion-channel activity using a real-time PCR machine. , 2009, BioTechniques.
[25] B. Nilius,et al. The taste transduction channel TRPM5 is a locus for bitter‐sweet taste interactions , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[26] T. Gudermann,et al. TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells , 2007, BMC Neuroscience.
[27] M. Freichel,et al. Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4 , 2007, Nature Immunology.
[28] N. Ryba,et al. The receptors and cells for mammalian taste , 2006, Nature.
[29] R. Vennekens,et al. Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice. , 2005, Cell calcium.
[30] S. Dworetzky,et al. A Thallium-Sensitive, Fluorescence-Based Assay for Detecting and Characterizing Potassium Channel Modulators in Mammalian Cells , 2004, Journal of biomolecular screening.
[31] E. Liman,et al. Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5 , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[32] R. Penner,et al. TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[33] A. Perraud,et al. TRPM4 Is a Ca2+-Activated Nonselective Cation Channel Mediating Cell Membrane Depolarization , 2002, Cell.
[34] Liquan Huang,et al. A transient receptor potential channel expressed in taste receptor cells , 2002, Nature Neuroscience.
[35] Thomas D. Y. Chung,et al. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays , 1999, Journal of biomolecular screening.
[36] R. Fromtling. Overview of medically important antifungal azole derivatives , 1988, Clinical Microbiology Reviews.
[37] E. Neher,et al. Inward current channels activated by intracellular Ca in cultured cardiac cells , 1981, Nature.