Highly unsaturated fatty acid synthesis in vertebrates: New insights with the cloning and characterization of a Δ6 desaturase of Atlantic salmon

[1]  D. Tocher,et al.  Effect of temperature on the incorporation into phospholipid classes and metabolismvia desaturation and elongation of n−3 and n−6 polyunsaturated fatty acids in fish cells in culture , 1990, Lipids.

[2]  D. Tocher,et al.  Molecular Cloning and Functional Characterization of Fatty Acyl Desaturase and Elongase cDNAs Involved in the Production of Eicosapentaenoic and Docosahexaenoic Acids from α-Linolenic Acid in Atlantic Salmon (Salmo salar) , 2004, Marine Biotechnology.

[3]  D. Tocher,et al.  Characterization and comparison of fatty acyl Delta6 desaturase cDNAs from freshwater and marine teleost fish species. , 2004, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[4]  Maggie B. Covington.  Omega-3 fatty acids. , 2004, American family physician.

[5]  J. G. Bell,et al.  Effects of diets containing vegetable oil on expression of genes involved in highly unsaturated fatty acid biosynthesis in liver of Atlantic salmon (Salmo salar) , 2004 .

[6]  J. G. Bell,et al.  Effects of diets containing linseed oil on fatty acid desaturation and oxidation in hepatocytes and intestinal enterocytes in Atlantic salmon (Salmo salar) , 2002, Fish Physiology and Biochemistry.

[7]  J. G. Bell,et al.  Polyunsaturated fatty acid metabolism in Atlantic salmon (Salmo salar) undergoing parr-smolt transformation and the effects of dietary linseed and rapeseed oils , 2000, Fish Physiology and Biochemistry.

[8]  J. G. Bell,et al.  Effects of water temperature and diets containing palm oil on fatty acid desaturation and oxidation in hepatocytes and intestinal enterocytes of rainbow trout (Oncorhynchus mykiss). , 2004, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[9]  T. Tonon,et al.  Identification of a very long chain polyunsaturated fatty acid Δ4‐desaturase from the microalga Pavlova lutheri 1 , 2003, FEBS letters.

[10]  Petra Cirpus,et al.  Biosynthesis of docosahexaenoic acid in Euglena gracilis: biochemical and molecular evidence for the involvement of a Delta4-fatty acyl group desaturase. , 2003, Biochemistry.

[11]  S. Panserat,et al.  Cloning and nutritional regulation of a Delta6-desaturase-like enzyme in the marine teleost gilthead seabream (Sparus aurata). , 2003, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[12]  J. G. Bell,et al.  Effects of dietary vegetable oil on atlantic salmon hepatocyte fatty acid desaturation and liver fatty acid compositions , 2003, Lipids.

[13]  P. Shewry,et al.  Identification of Primula fatty acid Δ6‐desaturases with n‐3 substrate preferences 1 , 2003 .

[14]  D. Tocher.  Metabolism and Functions of Lipids and Fatty Acids in Teleost Fish , 2003 .

[15]  S. Pereira,et al.  Recent advances in the study of fatty acid desaturases from animals and lower eukaryotes. , 2003, Prostaglandins, leukotrienes, and essential fatty acids.

[16]  J. Napier,et al.  The role of cytochrome b5 fusion desaturases in the synthesis of polyunsaturated fatty acids. , 2003, Prostaglandins, leukotrienes, and essential fatty acids.

[17]  T. Zank,et al.  The evolution of desaturases. , 2003, Prostaglandins, leukotrienes, and essential fatty acids.

[18]  J. Dick,et al.  Pyloric ceca are significant sites of newly synthesized 22∶6n−3 in rainbow trout (Oncorhynchus mykiss) , 2003, Lipids.

[19]  J. Watts,et al.  Polyunsaturated fatty acid synthesis: what will they think of next? , 2002, Trends in biochemical sciences.

[20]  H. Guillou,et al.  The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis. , 2002, The Biochemical journal.

[21]  S. Nwaka,et al.  Activity of human Δ5 and Δ6 desaturases on multiple n‐3 and n‐6 polyunsaturated fatty acids , 2001 .

[22]  D. Tocher,et al.  A vertebrate fatty acid desaturase with Δ5 and Δ6 activities , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[23]  G. Allan,et al.  Fish as food: aquaculture's contribution , 2001, EMBO reports.

[24]  J. Dick,et al.  Biosynthesis and tissue deposition of docosahexaenoic acid (22∶6n−3) in rainbow trout (Oncorhynchus mykiss) , 2001, Lipids.

[25]  X. Qiu,et al.  Identification of a (cid:1) 4 Fatty Acid Desaturase from Thraustochytrium sp. Involved in the Biosynthesis of Docosahexanoic Acid by Heterologous Expression in Saccharomyces cerevisiae and Brassica , 2001 .

[26]  S. Panserat,et al.  Cloning, tissue distribution and nutritional regulation of a Delta6-desaturase-like enzyme in rainbow trout. , 2001, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[27]  J. G. Bell,et al.  Replacement of fish oil with rapeseed oil in diets of Atlantic salmon (Salmo salar) affects tissue lipid compositions and hepatocyte fatty acid metabolism. , 2001, The Journal of nutrition.

[28]  H. Stöhr,et al.  cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. , 2000, Genomics.

[29]  J. Kopchick,et al.  cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid. , 2000, The Biochemical journal.

[30]  S. Barlow.  Fishmeal and fish oil : sustainable feed ingredients for aquafeeds , 2000 .

[31]  Manabu T. Nakamura,et al.  Cloning, Expression, and Fatty Acid Regulation of the Human Δ-5 Desaturase* , 1999, The Journal of Biological Chemistry.

[32]  Sunita Chaudhary,et al.  Cloning of Δ12- and Δ6-desaturases from Mortierella alpina and recombinant production of γ-linolenic acid in Saccharomyces cerevisiae , 1999, Lipids.

[33]  A. Tacon,et al.  Development of farmed fish: a nutritionally necessary alternative to meat , 1999, Proceedings of the Nutrition Society.

[34]  D. Tocher,et al.  Fatty acid metabolism in marine fish: Low activity of fatty acyl Δ5 desaturation in gilthead sea bream (Sparus aurata) cells , 1999, Lipids.

[35]  D. Tocher,et al.  Low C18 to C20 fatty acid elongase activity and limited conversion of stearidonic acid, 18:4(n-3), to eicosapentaenoic acid, 20:5(n-3), in a cell line from the turbot, Scophthalmus maximus. , 1999, Biochimica et biophysica acta.

[36]  O. Suzuki,et al.  Molecular Cloning and Functional Characterization of Rat Δ-6 Fatty Acid Desaturase , 1999 .

[37]  J. Watts,et al.  Isolation and characterization of a Delta 5-fatty acid desaturase from Caenorhabditis elegans. , 1999, Archives of biochemistry and biophysics.

[38]  Manabu T. Nakamura,et al.  Cloning, Expression, and Nutritional Regulation of the Mammalian Δ-6 Desaturase* , 1999, The Journal of Biological Chemistry.

[39]  J. Napier,et al.  Functional identification of a fatty acid Δ5 desaturase gene from Caenorhabditis elegans , 1998 .

[40]  A. Stobart,et al.  Isolation of a Δ5-Fatty Acid Desaturase Gene fromMortierella alpina * , 1998, The Journal of Biological Chemistry.

[41]  D. Tocher,et al.  Recent advances in the biochemistry and molecular biology of fatty acyl desaturases. , 1998, Progress in lipid research.

[42]  S. Hey,et al.  Identification of a Caenorhabditis elegans Δ6-fatty-acid-desaturase by heterologous expression in Saccharomyces cerevisiae , 1998 .

[43]  J. G. Bell,et al.  The effect of dietary lipid on polyunsaturated fatty acid metabolism in Atlantic salmon (Salmo salar) undergoing parr-smolt transformation , 1997, Lipids.

[44]  Subcommittee on Poultry Nutrition.  Nutrient Requirements of Fish , 1993 .

[45]  W. Lands,et al.  Biochemistry and physiology of n‐3 fatty acids , 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[46]  A. Simopoulos.  Omega-3 fatty acids in health and disease and in growth and development. , 1991, The American journal of clinical nutrition.

[47]  D. Tocher,et al.  Incorporation into Phospholipid Classes and Metabolism via Desaturation and Elongation of Various 14C‐Labelled (n‐3) and (n‐6) Polyunsaturated Fatty Acids in Trout Astrocytes in Primary Culture , 1990, Journal of neurochemistry.

[48]  R. R. Brenner.  2 – Factors Influencing Fatty Acid Chain Elongation and Desaturation , 1989 .

[49]  A. Simopoulos.  Summary of the NATO advanced research workshop on dietary omega 3 and omega 6 fatty acids: biological effects and nutritional essentiality. , 1989, The Journal of nutrition.

[50]  A. Simopoulos.  Summary of the NATO Advanced Research Workshop on Dietary ω3 and ω6 Fatty Acids: Biological Effects and Nutritional Essentiality , 1989 .

[51]  N. Saitou,et al.  The neighbor-joining method: a new method for reconstructing phylogenetic trees. , 1987, Molecular biology and evolution.

[52]  F. Allendorf,et al.  Tetraploidy and the Evolution of Salmonid Fishes , 1984 .

[53]  R. R. Brenner,et al.  Nutritional and hormonal factors influencing desaturation of essential fatty acids. , 1981, Progress in lipid research.

[54]  J. S. Nelson,et al.  Fishes of the world. , 1978 .

[55]  R. Holman,et al.  Polyunsaturated fatty acids , 1977 .

[56]  P. Legrand,et al.  The same rat ∆6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis , 2022 .