Fecal Transplantation does not Transfer Either Susceptibility or Fecal Transplantation does not Transfer Either Susceptibility or Resistance to Food Borne Listeriosis in C57BL/6 and BALB/c/By Resistance to Food Borne Listeriosis in C57BL/6 and BALB/c/By Mice Mice

The composition of the intestinal microbiota has wide reaching effects on the health of an individual, including the development of protective innate immune responses. In this report, a fecal transplantation approach was used to determine whether resistance to food borne listeriosis was dependent on the murine gut microbiota. Transplantation of BALB/c/By feces did not increase the susceptibility of C57BL/6 mice to infection. Likewise, Listeria monocytogenes transplantation of C57BL/6 fecal matter did not enhance the resistance of BALB/c/By mice. Thus, intestinal microbiota composition is not a key factor that confers either susceptibility or resistance to food borne listeriosis in mice. Myers-Morales present results indicating that B6 or BALB mice depleted of gut flora using et al. streptomycin do not show altered resistance when given a fecal transplant from the opposing strain. The studies suggest, but do not prove, that gut flora do not contribute to the differing resistance of these strains. The article “Fecal transplantation does not transfer either susceptibility or resistance to food borne listeriosis in C57BL/6 and BALB/c/By mice” by Myers-Morales . demonstrates that the intestinal et al microbiota is not a major determinant in the differences in susceptibility between C57BL/6 and BALB/c/By mice. It is an important report of negative results.

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