miR-122 removal in the liver activates imprinted microRNAs and enables more effective microRNA-mediated gene repression

[1]  R. Darnell,et al.  Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer. , 2017, Molecular cell.

[2]  R. Chandler,et al.  Recombinant Adeno-Associated Viral Integration and Genotoxicity: Insights from Animal Models. , 2017, Human gene therapy.

[3]  SrivastavaArun,et al.  AAV Infection: Protection from Cancer. , 2017 .

[4]  Keith A. Boroevich,et al.  Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer , 2016, Nature Genetics.

[5]  Lan Jin,et al.  RNAi induced hepatotoxicity results from loss of the first synthesized isoform of miR-122 in mice , 2016, Nature Medicine.

[6]  D. Bartel,et al.  Predicting effective microRNA target sites in mammalian mRNAs , 2015, eLife.

[7]  Jessica Zucman-Rossi,et al.  Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets , 2015, Nature Genetics.

[8]  N. Proudfoot,et al.  Microprocessor mediates transcriptional termination in long noncoding microRNA genes , 2015, Nature Structural &Molecular Biology.

[9]  A. Elkahloun,et al.  Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy. , 2015, The Journal of clinical investigation.

[10]  Yi-Ming Sun,et al.  Integrated analyses to reconstruct microRNA-mediated regulatory networks in mouse liver using high-throughput profiling , 2015, BMC Genomics.

[11]  Vikram Agarwal,et al.  Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance. , 2014, Molecular cell.

[12]  Mark A. Kay,et al.  Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma , 2013, Oncogene.

[13]  Hsien-Da Huang,et al.  MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. , 2012, The Journal of clinical investigation.

[14]  M. Caligiuri,et al.  Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. , 2012, The Journal of clinical investigation.

[15]  R. Sachidanandam,et al.  High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries , 2012, Nature Methods.

[16]  Pei-Rong Wang,et al.  Induction of hepatocellular carcinoma by in vivo gene targeting , 2012, Proceedings of the National Academy of Sciences.

[17]  David R. Kelley,et al.  Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks , 2012, Nature Protocols.

[18]  Hongyue Dai,et al.  DLK1-DIO3 Genomic Imprinted MicroRNA Cluster at 14q32.2 Defines a Stemlike Subtype of Hepatocellular Carcinoma Associated with Poor Survival , 2011, The Journal of Biological Chemistry.

[19]  Hui Zhou,et al.  Liver‐enriched transcription factors regulate MicroRNA‐122 that targets CUTL1 during liver development , 2010, Hepatology.

[20]  Nicholas T. Ingolia,et al.  Mammalian microRNAs predominantly act to decrease target mRNA levels , 2010, Nature.

[21]  Tomohiro Kono,et al.  Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells , 2010, Nature.

[22]  Cole Trapnell,et al.  Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. , 2010, Nature biotechnology.

[23]  T. Tuschl,et al.  Absolute quantification of microRNAs by using a universal reference. , 2009, RNA.

[24]  Charles E. Vejnar,et al.  Integration of microRNA miR-122 in hepatic circadian gene expression. , 2009, Genes & development.

[25]  Michael T. McManus,et al.  Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis. , 2009, Gastroenterology.

[26]  Martin L. Miller,et al.  Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs , 2009, Nature Biotechnology.

[27]  Cole Trapnell,et al.  Ultrafast and memory-efficient alignment of short DNA sequences to the human genome , 2009, Genome Biology.

[28]  T. Katoh,et al.  Selective stabilization of mammalian microRNAs by 3' adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2. , 2009, Genes & development.

[29]  Brad T. Sherman,et al.  Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists , 2008, Nucleic acids research.

[30]  S. Kauppinen,et al.  LNA-mediated microRNA silencing in non-human primates , 2008, Nature.

[31]  A. Silahtaroglu,et al.  Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver , 2007, Nucleic acids research.

[32]  Aarati R. Ranade,et al.  Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice , 2007, Nature Biotechnology.

[33]  Daniel G. Miller,et al.  AAV Vector Integration Sites in Mouse Hepatocellular Carcinoma , 2007, Science.

[34]  C. Sander,et al.  A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing , 2007, Cell.

[35]  Theresa A. Storm,et al.  Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways , 2006, Nature.

[36]  N. Rajewsky,et al.  Silencing of microRNAs in vivo with ‘antagomirs’ , 2005, Nature.

[37]  Theresa A. Storm,et al.  Large-Scale Molecular Characterization of Adeno-Associated Virus Vector Integration in Mouse Liver , 2005, Journal of Virology.

[38]  C. Burge,et al.  Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets , 2005, Cell.

[39]  C. Sander,et al.  miR-122, a Mammalian Liver-Specific microRNA, is Processed from hcr mRNA and MayDownregulate the High Affinity Cationic Amino Acid Transporter CAT-1 , 2004, RNA biology.

[40]  T. Tuschl,et al.  Identification of Tissue-Specific MicroRNAs from Mouse , 2002, Current Biology.

[41]  A. Srivastava,et al.  AAV Infection: Protection from Cancer. , 2017, Human gene therapy.

[42]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.