Convenient Direct Syntheses of Selectively para‐Substituted Di‐, Tri‐ and Tetra‐Formylated Thiacalix[4]arenes

An efficient direct method for di-, tri- and tetraformylation of thiacalix[4]arenes substituted on the para positions is described. Di- and triformylated thiacalix[4]arenes were obtained by formylation of partially propyl- or benzoyl-substituted thiacalix[4]arenes. Complete para-formylation was successfully achieved by formylation and dealkylation of tetraisopropoxythiacalix[4]arene conformers in one step. This experimental procedure is a simpler synthesis for completely formylated thiacalix[4]arene than the indirect method reported previously from brominated thiacalix[4]arene.

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