Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies

[1]  Julia K Mader,et al.  Adipose tissue, inflammation and cardiovascular disease. , 2010, Revista da Associacao Medica Brasileira.

[2]  Alfonso T. Perez,et al.  Increased High-Density Lipoprotein Cholesterol Predicts the Pioglitazone-Mediated Reduction of Carotid Intima-Media Thickness Progression in Patients With Type 2 Diabetes Mellitus , 2008, Circulation.

[3]  M. Caulfield,et al.  Effects of torcetrapib in patients at high risk for coronary events , 2008 .

[4]  R. Unger.  Reinventing type 2 diabetes: pathogenesis, treatment, and prevention. , 2008, JAMA.

[5]  A. Chait,et al.  Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice , 2008, Proceedings of the National Academy of Sciences.

[6]  S. Griffen,et al.  Increased Toll-like Receptor (tlr) 2 and Tlr4 Expression in Monocytes from Patients with Type 1 Diabetes: Further , 2022 .

[7]  B. Thiers.  Retinaldehyde represses adipogenesis and diet-induced obesity , 2008 .

[8]  A. Chait,et al.  Diabetes and Arterial Extracellular Matrix Changes in a Porcine Model of Atherosclerosis , 2007, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[9]  J. Borén,et al.  Ira Tabas , Kevin Jon Williams and Jan Borén and Therapeutic Implications Subendothelial Lipoprotein Retention as the Initiating Process in Atherosclerosis : Update , 2007 .

[10]  G. Bondjers,et al.  Fatty acid-induced atherogenic changes in extracellular matrix proteoglycans , 2007, Current opinion in lipidology.

[11]  Margaret F. Gregor,et al.  Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease Published, JLR Papers in Press, May 9, 2007. , 2007, Journal of Lipid Research.

[12]  Y. Naito,et al.  Short-term high glucose exposure induces monocyte-endothelial cells adhesion and transmigration by increasing VCAM-1 and MCP-1 expression in human aortic endothelial cells. , 2007, Atherosclerosis.

[13]  P. Ridker,et al.  Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. , 2007, JAMA.

[14]  B. Nordestgaard,et al.  Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. , 2007, JAMA.

[15]  T. Mazzone.  HDL cholesterol and atherosclerosis , 2007, The Lancet.

[16]  R. Kawamori,et al.  Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E-deficient mice. , 2007, Biochemical and biophysical research communications.

[17]  S. Devaraj,et al.  High glucose induces IL-1beta expression in human monocytes: mechanistic insights. , 2007, American journal of physiology. Endocrinology and metabolism.

[18]  P. Walter,et al.  Signal integration in the endoplasmic reticulum unfolded protein response , 2007, Nature Reviews Molecular Cell Biology.

[19]  Frank Brombacher,et al.  Macrophage-specific PPARγ controls alternative activation and improves insulin resistance , 2007, Nature.

[20]  D. Sviridov,et al.  Advanced glycation of apolipoprotein A-I impairs its anti-atherogenic properties , 2007, Diabetologia.

[21]  D. Goff,et al.  Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: design and methods. , 2007, The American journal of cardiology.

[22]  A. Tall,et al.  The Macrophage at the Crossroads of Insulin Resistance and Atherosclerosis , 2007, Circulation research.

[23]  P. Libby,et al.  AGE-BSA decreases ABCG1 expression and reduces macrophage cholesterol efflux to HDL. , 2007, Atherosclerosis.

[24]  C. Glass,et al.  Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. , 2007, The Journal of clinical investigation.

[25]  J. Eckel,et al.  Monocyte chemotactic protein-1 and its role in insulin resistance , 2007, Current opinion in lipidology.

[26]  D. Shih,et al.  Adenovirus-Mediated Expression of Human Paraoxonase 3 Protects Against the Progression of Atherosclerosis in Apolipoprotein E–Deficient Mice , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[27]  A. Lusis,et al.  High-Density Lipoprotein Modulates Oxidized Phospholipid Signaling in Human Endothelial Cells From Proinflammatory to Anti-inflammatory , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[28]  S. Pennathur,et al.  Mechanisms for oxidative stress in diabetic cardiovascular disease. , 2007, Antioxidants & redox signaling.

[29]  J. Oram,et al.  Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C δ pathway Published, JLR Papers in Press, February 28, 2007. , 2007, Journal of Lipid Research.

[30]  Moyses Szklo,et al.  LDL particle subclasses, LDL particle size, and carotid atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA). , 2007, Atherosclerosis.

[31]  M. Jaye,et al.  Predominance of a Proinflammatory Phenotype in Monocyte-Derived Macrophages From Subjects With Low Plasma HDL-Cholesterol , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[32]  G. Fantuzzi,et al.  Adipose Tissue and Atherosclerosis: Exploring the Connection , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[33]  G. Hansson,et al.  5-Lipoxygenase–Activating Protein: A Potential Link Between Innate and Adaptive Immunity in Atherosclerosis and Adipose Tissue Inflammation , 2007, Circulation research.

[34]  M. Roden,et al.  Mitochondrial function and endocrine diseases , 2007 .

[35]  Kenneth K. Wu,et al.  Diabetic atherosclerosis mouse models. , 2007, Atherosclerosis.

[36]  M. Hersberger,et al.  Genetic deletion of p66Shc adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress , 2007, Proceedings of the National Academy of Sciences.

[37]  Leif E. Peterson,et al.  T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity , 2007, Circulation.

[38]  S. Simon,et al.  Triglyceride-Rich Lipoproteins Prime Aortic Endothelium for an Enhanced Inflammatory Response to Tumor Necrosis Factor-α , 2007, Circulation research.

[39]  Nicholas J Wareham,et al.  Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study. , 2007, Journal of the American College of Cardiology.

[40]  A. Luder,et al.  LDL oxidation is associated with increased blood hemoglobin A1c levels in diabetic patients. , 2007, Clinica chimica acta; international journal of clinical chemistry.

[41]  R. Carmody,et al.  Nuclear factor-kappaB: activation and regulation during toll-like receptor signaling. , 2007, Cellular & molecular immunology.

[42]  J. Plutzky,et al.  Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. , 2007, Circulation.

[43]  Margaret F. Gregor,et al.  Adipocyte stress: the endoplasmic reticulum and metabolic disease , 2007 .

[44]  M. Hersberger,et al.  Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress. , 2007, Proceedings of the National Academy of Sciences of the United States of America.

[45]  G. King,et al.  Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes , 2007, Nature Clinical Practice Endocrinology &Metabolism.

[46]  J. Oram,et al.  Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C delta pathway. , 2007, Journal of lipid research.

[47]  G. Hotamisligil,et al.  Inflammation and metabolic disorders , 2006, Nature.

[48]  C. Block,et al.  Mechanisms linking obesity with cardiovascular disease , 2006, Nature.

[49]  S. Haffner,et al.  Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial. , 2006, JAMA.

[50]  V. Ruíz-Gutiérrez,et al.  Fatty acid composition of chylomicron remnant‐like particles influences their uptake and induction of lipid accumulation in macrophages , 2006, The FEBS journal.

[51]  Z. Huang,et al.  Endogenous ApoE Expression Modulates Adipocyte Triglyceride Content and Turnover , 2006, Diabetes.

[52]  J. Flier,et al.  TLR4 links innate immunity and fatty acid-induced insulin resistance. , 2006, The Journal of clinical investigation.

[53]  Aiqing He,et al.  The Unfolded Protein Response Is an Important Regulator of Inflammatory Genes in Endothelial Cells , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[54]  J. Stypmann,et al.  High-Density Lipoproteins and Their Constituent, Sphingosine-1-Phosphate, Directly Protect the Heart Against Ischemia/Reperfusion Injury In Vivo via the S1P3 Lysophospholipid Receptor , 2006, Circulation.

[55]  A. Goldfine,et al.  Inflammation and insulin resistance. , 2006, The Journal of clinical investigation.

[56]  Kohjiro Ueki,et al.  Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. , 2006, The Journal of clinical investigation.

[57]  V. Saraswathi,et al.  The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophages Published, JLR Papers in Press, April 25, 2006. , 2006, Journal of Lipid Research.

[58]  D. Rader,et al.  Macrophage reverse cholesterol transport: key to the regression of atherosclerosis? , 2006, Circulation.

[59]  P. Barter,et al.  High-Density Lipoproteins Enhance Progenitor-Mediated Endothelium Repair in Mice , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[60]  João Costa,et al.  Efficacy of lipid lowering drug treatment for diabetic and non-diabetic patients: metaanalysis of randomised controlled trials , 2006, BMJ : British Medical Journal.

[61]  D. Accili,et al.  Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. , 2006, Cell metabolism.

[62]  A. Hoffmann,et al.  Circuitry of nuclear factor κB signaling , 2006 .

[63]  H. Bloomfield,et al.  Low-Density Lipoprotein and High-Density Lipoprotein Particle Subclasses Predict Coronary Events and Are Favorably Changed by Gemfibrozil Therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial , 2006, Circulation.

[64]  S. Griffen,et al.  Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes. , 2006, Diabetes.

[65]  C. Kahn,et al.  From mice to men: insights into the insulin resistance syndromes. , 2006, Annual review of physiology.

[66]  R. Leibel,et al.  CCR2 modulates inflammatory and metabolic effects of high-fat feeding. , 2006, The Journal of clinical investigation.

[67]  J. Olefsky,et al.  Inflamed fat: what starts the fire? , 2005, The Journal of clinical investigation.

[68]  大岡 愛子,et al.  Temporary hyperglycaemia provokes monocyte adhesion to endothelial cells in rat thoracic aorta , 2006 .

[69]  H. Ginsberg,et al.  Diabetic dyslipidemia. , 2006, Endocrinology and metabolism clinics of North America.

[70]  D. Praticò,et al.  Thromboxane, prostacyclin and isoprostanes: therapeutic targets in atherogenesis. , 2005, Trends in pharmacological sciences.

[71]  A. Ceriello,et al.  Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production. , 2005, Atherosclerosis.

[72]  K. V. van Dijk,et al.  Role of the macrophage very-low-density lipoprotein receptor in atherosclerotic lesion development. , 2005, Atherosclerosis.

[73]  J. Hanover,et al.  The Hexosamine Signaling Pathway: Deciphering the "O-GlcNAc Code" , 2005, Science's STKE.

[74]  R. Cohen.  Role of Nitric Oxide in Diabetic Complications , 2005, American journal of therapeutics.

[75]  D. Rader,et al.  Increased Atherosclerosis in Mice Lacking Apolipoprotein A-I Attributable to Both Impaired Reverse Cholesterol Transport and Increased Inflammation , 2005, Circulation research.

[76]  E. Schaefer,et al.  Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux Published, JLR Papers in Press, August 1, 2005. DOI 10.1194/jlr.M500187-JLR200 , 2005, Journal of Lipid Research.

[77]  E. Trimble,et al.  Activation of peripheral blood CD14+ monocytes occurs in diabetes. , 2005, Diabetes.

[78]  Christine M. Williams,et al.  Differential uptake of subfractions of triglyceride-rich lipoproteins by THP-1 macrophages. , 2005, Atherosclerosis.

[79]  P. Eriksson,et al.  High-Density Lipoproteins Induce Transforming Growth Factor-&bgr;2 Expression in Endothelial Cells , 2005 .

[80]  P. Scherer,et al.  Adipose tissue, inflammation, and cardiovascular disease. , 2005, Circulation research.

[81]  M. Hofker,et al.  Nuclear Factor &kgr;B Signaling in Atherogenesis , 2005 .

[82]  G. Hansson.  Inflammation, atherosclerosis, and coronary artery disease. , 2005, The New England journal of medicine.

[83]  G. King,et al.  Proatherosclerotic Mechanisms Involving Protein Kinase C in Diabetes and Insulin Resistance , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[84]  P. Iyengar,et al.  The Hyperglycemia-induced Inflammatory Response in Adipocytes , 2005, Journal of Biological Chemistry.

[85]  P. Eriksson,et al.  High-density lipoproteins induce transforming growth factor-beta2 expression in endothelial cells. , 2005, Circulation.

[86]  G Hu,et al.  Prediction of the risk of cardiovascular mortality using a score that includes glucose as a risk factor. The DECODE Study , 2004, Diabetologia.

[87]  T. Mazzone,et al.  Divergent Effects of Peroxisome Proliferator-activated Receptor γ Agonists and Tumor Necrosis Factor α on Adipocyte ApoE Expression* , 2004, Journal of Biological Chemistry.

[88]  B. Friedrich,et al.  Activation of nuclear factor-kappaB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase. , 2004, Diabetes.

[89]  P. Barter,et al.  Antiinflammatory Properties of HDL , 2004 .

[90]  A. Chait,et al.  Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions. , 2004, The Journal of clinical investigation.

[91]  John H Fuller,et al.  Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial , 2004, The Lancet.

[92]  Nader Rifai,et al.  Non-HDL cholesterol and apolipoprotein B predict cardiovascular disease events among men with type 2 diabetes. , 2004, Diabetes care.

[93]  J. Plutzky,et al.  Lipolytic PPAR activation: new insights into the intersection of triglycerides and inflammation? , 2004, Current opinion in clinical nutrition and metabolic care.

[94]  R. Virmani,et al.  Morphologic Findings of Coronary Atherosclerotic Plaques in Diabetics: A Postmortem Study , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[95]  I. Young,et al.  Susceptibility of low-density lipoprotein to oxidation and circulating cell adhesion molecules in young healthy adult offspring of parents with type 2 diabetes. , 2004, Metabolism: clinical and experimental.

[96]  H. Shin,et al.  Remnant Lipoprotein Particles Induce Apoptosis in Endothelial Cells by NAD(P)H Oxidase–Mediated Production of Superoxide and Cytokines via Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Activation: Prevention by Cilostazol , 2004, Circulation.

[97]  N. Wong,et al.  Transcriptional control of apolipoprotein A-I gene expression in diabetes. , 2004, Diabetes.

[98]  L. Rasmussen,et al.  Glycosaminoglycans in the human aorta in diabetes mellitus: a study of tunica media from areas with and without atherosclerotic plaque , 1994, Diabetologia.

[99]  H. Makino,et al.  Mechanisms involved in the stimulatory effect of advanced glycation end products on growth of rat aortic smooth muscle cells. , 2003, Metabolism: clinical and experimental.

[100]  Sarah Parish,et al.  MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial , 2003, The Lancet.

[101]  M. Itoh,et al.  Statins inhibit high glucose-mediated neutrophil-endothelial cell adhesion through decreasing surface expression of endothelial adhesion molecules by stimulating production of endothelial nitric oxide. , 2003, Microvascular research.

[102]  D. Rader,et al.  Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: Evidence for an antiinflammatory role for lipoprotein lipase , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[103]  A. Jenkins,et al.  Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance. , 2003, Diabetes.

[104]  S. Horiuchi,et al.  Advanced glycation end products (AGE) inhibit scavenger receptor class B type I-mediated reverse cholesterol transport: a new crossroad of AGE to cholesterol metabolism. , 2003, Journal of atherosclerosis and thrombosis.

[105]  Michael Karin,et al.  A central role for JNK in obesity and insulin resistance , 2002, Nature.

[106]  S. Devaraj,et al.  α-Tocopherol Decreases Superoxide Anion Release in Human Monocytes Under Hyperglycemic Conditions Via Inhibition of Protein Kinase C-α , 2002 .

[107]  C. Fox,et al.  Progesterone inhibits human infragenicular arterial smooth muscle cell proliferation induced by high glucose and insulin concentrations. , 2002, Journal of vascular surgery.

[108]  J. Friedman,et al.  The function of leptin in nutrition, weight, and physiology. , 2002, Nutrition reviews.

[109]  S. Horiuchi,et al.  Scavenger receptors that recognize advanced glycation end products. , 2002, Trends in cardiovascular medicine.

[110]  Alice Arnold,et al.  Nuclear Magnetic Resonance Spectroscopy of Lipoproteins and Risk of Coronary Heart Disease in the Cardiovascular Health Study , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[111]  Grupa nadzorująca badanie Advance.  Study rationale and design of ADVANCE: action in diabetes and vascular disease-preterax and diamicron MR controlled evaluation , 2002 .

[112]  S. Devaraj,et al.  Alpha-tocopherol decreases superoxide anion release in human monocytes under hyperglycemic conditions via inhibition of protein kinase C-alpha. , 2002, Diabetes.

[113]  M. Brownlee.  Biochemistry and molecular cell biology of diabetic complications , 2001, Nature.

[114]  E. Fisher,et al.  Elevating High-Density Lipoprotein Cholesterol in Apolipoprotein E—Deficient Mice Remodels Advanced Atherosclerotic Lesions by Decreasing Macrophage and Increasing Smooth Muscle Cell Content , 2001, Circulation.

[115]  A. Sniderman,et al.  Hypertriglyceridemic HyperapoB: The Unappreciated Atherogenic Dyslipoproteinemia in Type 2 Diabetes Mellitus , 2001, Annals of Internal Medicine.

[116]  R. Natarajan,et al.  Diabetes-induced accelerated atherosclerosis in swine. , 2001, Diabetes.

[117]  P. Nestel,et al.  Post-prandial remnant lipids impair arterial compliance. , 2001, Journal of the American College of Cardiology.

[118]  K. Litwak,et al.  A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease. , 2001, The Journal of clinical investigation.

[119]  I. Goldberg.  Diabetic Dyslipidemia: Causes and Consequences , 2001 .

[120]  I. Goldberg,et al.  Clinical review 124: Diabetic dyslipidemia: causes and consequences. , 2001, The Journal of clinical endocrinology and metabolism.

[121]  A. Chait,et al.  Increased uptake of alpha-hydroxy aldehyde-modified low density lipoprotein by macrophage scavenger receptors. , 2000, Journal of lipid research.

[122]  James W. Anderson,et al.  Decreased protection by HDL from poorly controlled type 2 diabetic subjects against LDL oxidation may Be due to the abnormal composition of HDL. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[123]  G. Davı̀,et al.  In Vivo Formation of 8-Iso-Prostaglandin F2α and Platelet Activation in Diabetes Mellitus , 1999 .

[124]  R. Holman,et al.  Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. , 1998 .

[125]  A. Baron,et al.  Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. , 1997, The Journal of clinical investigation.

[126]  T. Lyons,et al.  Age-dependent increase in ortho-tyrosine and methionine sulfoxide in human skin collagen is not accelerated in diabetes. Evidence against a generalized increase in oxidative stress in diabetes. , 1997, The Journal of clinical investigation.

[127]  J. Parks,et al.  Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness. , 1995, The American journal of clinical nutrition.

[128]  P. Libby,et al.  Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. , 1995, The Journal of clinical investigation.

[129]  A. Chait,et al.  Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway. , 1994, The Journal of clinical investigation.

[130]  Y. Zou,et al.  Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. , 1994, The Journal of biological chemistry.

[131]  B. Spiegelman,et al.  Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. , 1993, Science.

[132]  K. Tracey,et al.  Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. , 1991, The Journal of clinical investigation.

[133]  R. M. Lee,et al.  Alterations of elastin and elastase-like activities in aortae of diabetic rats. , 1988, Biochimica et biophysica acta.

[134]  A. Cerami,et al.  Nonenzymatic Glycosylation Products on Collagen Covalently Trap Low-Density Lipoprotein , 1985, Diabetes.

[135]  P. O'brien.  [47] Superoxide production , 1984 .

[136]  H. Ditschuneit,et al.  The effect of insulin and insulin-like growth factors on cell proliferation of human smooth muscle cells. , 1980, Artery.