Quantitation of Cell Shedding into Efferent Blood of Mammary 1

SUMMARY The rate of tumor cell shedding into efferent tumor blood was measured in growing and regressing MTW9 rat mam carcinomas. hormone-dependent tumor, as an “isolatedâ€(cid:157)preparation (8), permitted collection of all of the efferent blood. Regression was induced by reduction of mammotropin level in the host. Tumor cells were differenti ated from normal leukocytes by indirect immunofluores cence. Growing tumors shed 3.2 x 106 and regressing tumors shed 4. 1 x 106 cells per 24 hr per g tissue. Cell shedding rates ofgrowing versus regressing tumors were not significantly different over a tumor size range of 2 to 4 g. (a) (b)

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