An outbreak of candidemia due to Candida tropicalis in a neonatal intensive care unit

An outbreak of candidemia due to Candida tropicalis involving 16 neonates (gestational age 28–36 weeks) is reported. All infants had received hyperalimentation and at least one course of antibiotics. The commonest clinical manifestations included episodes of acute respiratory distress and lack of response to antibacterial antibiotic therapy. Candida tropicalis was recovered from blood in all the 16 infants and urine cultures were positive in 14 infants. Environmental sampling yielded C. tropicalis from one each of the blankets and mattresses used for neonates. Four of five urinary tract isolates and both environmental isolates genotyped by arbitrarily primed‐PCR with several random primers were shown to belong to the same genotype.

[1]  S. Rao,et al.  Systemic fungal infections in neonates. , 2005, Journal of postgraduate medicine.

[2]  M. Ghannoum,et al.  Quality Control Limits for Broth Microdilution Susceptibility Tests of Ten Antifungal Agents , 2000, Journal of Clinical Microbiology.

[3]  K. Becker,et al.  Molecular genotyping of Candida species with special respect to Candida (Torulopsis) glabrata strains by arbitrarily primed PCR. , 2000, Journal of Medical Microbiology.

[4]  D. Shin,et al.  Nosocomial Cluster of Candida lipolytica Fungemia in Pediatric Patients , 2000, European Journal of Clinical Microbiology and Infectious Diseases.

[5]  K. Prasad,et al.  Role of yeasts as nosocomial pathogens & their susceptibility to fluconazole & amphotericin B. , 1999, The Indian journal of medical research.

[6]  L. Rubin,et al.  Emergence of Candida parapsilosis as the predominant species causing candidemia in children. , 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[7]  A. Chakrabarti,et al.  Epidemiology of systemic candidiasis in a tertiary care neonatal unit. , 1998, Journal of tropical pediatrics.

[8]  W J Martone,et al.  Nosocomial infections among neonates in high-risk nurseries in the United States. National Nosocomial Infections Surveillance System. , 1996, Pediatrics.

[9]  A. Chakrabarti,et al.  Antifungal susceptibility pattern of non-albicans Candida species & distribution of species isolated from Candidaemia cases over a 5 year period. , 1996, The Indian journal of medical research.

[10]  M. Pfaller,et al.  Epidemiology of candidiasis. , 1995, The Journal of hospital infection.

[11]  A. Rowley,et al.  Candidemia in a pediatric population. , 1995, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[12]  W. C. Dunagan,et al.  Candiduria: Retrospective Review in Hospitalized Patients , 1994 .

[13]  N. Hashman,et al.  Outbreak of Candida tropicalis Fungemia in a Neonatal Intensive Care Unit , 1993, Infection Control & Hospital Epidemiology.

[14]  J. Sobel,et al.  Nosocomial acquisition of Candida parapsilosis: an epidemiologic study. , 1993, The American journal of medicine.

[15]  J. Sobel,et al.  Epidemiology of nosocomial acquisition of Candida lusitaniae , 1992, Journal of clinical microbiology.

[16]  R. Ivatury,et al.  Candiduria as an early marker of disseminated infection in critically ill surgical patients: the role of fluconazole therapy. , 1992, The Journal of trauma.

[17]  B. Doebbeling,et al.  Restriction fragment analysis of a Candida tropicalis outbreak of sternal wound infections , 1991, Journal of clinical microbiology.

[18]  J. Baley.  Neonatal candidiasis: the current challenge. , 1991, Clinics in perinatology.

[19]  D. Tyras,et al.  Single-source outbreak of Candida tropicalis complicating coronary bypass surgery , 1989, Journal of clinical microbiology.

[20]  K. Butler,et al.  Candida: an increasingly important pathogen in the nursery. , 1988, Pediatric clinics of North America.

[21]  S. Shulman,et al.  Risk factors associated with candidemia in the neonatal intensive care unit: a case‐control study , 1987, The Pediatric infectious disease journal.

[22]  A. Fanaroff,et al.  Fungal colonization in the very low birth weight infant. , 1986, Pediatrics.

[23]  J. Wingard,et al.  Candida tropicalis: a major pathogen in immunocompromised patients. , 1979, Annals of internal medicine.

[24]  U. Banerjee,et al.  Outbreak of systemic candidiasis in low birth weight preterm infants at a neonatal Intensive Care Unit , 2000 .

[25]  K. Barnhart.  Increased Efficiency of Arbitrarily Primed PCR by Prolonged Ramp Times , 1999 .

[26]  Pfaller.  NOSOCOMIAL FUNGAL INFECTIONS; EPIDEMIOLOGY OF CANDIDIASIS , 1995 .

[27]  M. Moro,et al.  Nosocomial outbreak of systemic candidosis associated with parenteral nutrition. , 1990 .

[28]  R. Payne,et al.  Yeasts: Characteristics and Identification , 1983 .