Complex trait mapping in isolated populations: Are specific statistical methods required?

[1]  Mario Falchi,et al.  A genomewide search using an original pairwise sampling approach for large genealogies identifies a new locus for total and low-density lipoprotein cholesterol in two genetically differentiated isolates of Sardinia. , 2004, American journal of human genetics.

[2]  J. Gulcher,et al.  Linkage of Osteoporosis to Chromosome 20p12 and Association to BMP2 , 2003, PLoS biology.

[3]  J. Gulcher,et al.  Localization of a gene for migraine without aura to chromosome 4q21. , 2003, American journal of human genetics.

[4]  Mark Gurney,et al.  The gene encoding phosphodiesterase 4D confers risk of ischemic stroke , 2003, Nature Genetics.

[5]  Jianping Dong,et al.  Transmission/disequilibrium test based on haplotype sharing for tightly linked markers. , 2003, American journal of human genetics.

[6]  Mary Sara McPeek,et al.  Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus. , 2003, American journal of human genetics.

[7]  Bernard Prum,et al.  Estimation of the inbreeding coefficient through use of genomic data. , 2003, American journal of human genetics.

[8]  J. Gulcher,et al.  Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2. , 2003, American journal of human genetics.

[9]  J. Gulcher,et al.  Genomewide scan for hand osteoarthritis: a novel mutation in matrilin-3. , 2003, American journal of human genetics.

[10]  T. Thorgeirsson,et al.  Anxiety with panic disorder linked to chromosome 9q in Iceland. , 2003, American journal of human genetics.

[11]  L. Wasserman,et al.  On the identification of disease mutations by the analysis of haplotype similarity and goodness of fit. , 2003, American journal of human genetics.

[12]  Elizabeth A Thompson,et al.  Impact of parental relationships in maximum lod score affected sib‐pair method , 2002, Genetic epidemiology.

[13]  Hreinn Stefánsson,et al.  A susceptibility gene for late‐onset idiopathic Parkinson's disease , 2002, Annals of neurology.

[14]  H. Stefánsson,et al.  Neuregulin 1 and susceptibility to schizophrenia. , 2002, American journal of human genetics.

[15]  P. Heutink,et al.  Gene finding in genetically isolated populations. , 2002, Human molecular genetics.

[16]  J. Gulcher,et al.  A major susceptibility gene for asthma maps to chromosome 14q24. , 2002, American journal of human genetics.

[17]  Shaun Purcell,et al.  Powerful regression-based quantitative-trait linkage analysis of general pedigrees. , 2002, American journal of human genetics.

[18]  J. Gulcher,et al.  Linkage of Essential Hypertension to Chromosome 18q , 2002, Hypertension.

[19]  J. Blangero,et al.  Genes on chromosomes 1 and 13 have significant effects on Ascaris infection , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[20]  M. McPeek,et al.  Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites. , 2002, American journal of human genetics.

[21]  Vilmundur Gudnason,et al.  Localization of a susceptibility gene for common forms of stroke to 5q12. , 2002, American journal of human genetics.

[22]  E. Génin,et al.  Properties of the transmission‐disequilibrium test in the presence of inbreeding , 2002, Genetic epidemiology.

[23]  Kathryn Roeder,et al.  Association studies for quantitative traits in structured populations , 2002, Genetic epidemiology.

[24]  M. Escamilla.  Population isolates: their special value for locating genes for bipolar disorder. , 2001, Bipolar disorders.

[25]  N J Cox,et al.  The importance of genealogy in determining genetic associations with complex traits. , 2001, American journal of human genetics.

[26]  Sagiv Shifman,et al.  The value of isolated populations , 2001, Nature Genetics.

[27]  A. Kong,et al.  The role of linkage studies for common diseases. , 2001, Current opinion in genetics & development.

[28]  Mourad Sahbatou,et al.  Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease , 2001, Nature.

[29]  K. Roeder,et al.  Transmission/disequilibrium test meets measured haplotype analysis: family-based association analysis guided by evolution of haplotypes. , 2001, American journal of human genetics.

[30]  N. Laird,et al.  The family based association test method: strategies for studying general genotype–phenotype associations , 2001, European Journal of Human Genetics.

[31]  D. Reich,et al.  Detecting association in a case‐control study while correcting for population stratification , 2001, Genetic epidemiology.

[32]  A A Hicks,et al.  Familial aggregation of Parkinson's disease in Iceland. , 2000, The New England journal of medicine.

[33]  N M Laird,et al.  Family-based tests of association in the presence of linkage. , 2000, American journal of human genetics.

[34]  Tom H. Lindner,et al.  Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus , 2000, Nature Genetics.

[35]  K. Kidd,et al.  Transmission/disequilibrium tests using multiple tightly linked markers. , 2000, American journal of human genetics.

[36]  E. Martin,et al.  A test for linkage and association in general pedigrees: the pedigree disequilibrium test. , 2000, American journal of human genetics.

[37]  K. Roeder,et al.  The power of genomic control. , 2000, American journal of human genetics.

[38]  E. Génin,et al.  Search for multifactorial disease susceptibility genes in founder populations , 2000, Annals of human genetics.

[39]  Daniel F. Gudbjartsson,et al.  Allegro, a new computer program for multipoint linkage analysis , 2000, Nature genetics.

[40]  Daniel Rabinowitz,et al.  A Unified Approach to Adjusting Association Tests for Population Admixture with Arbitrary Pedigree Structure and Arbitrary Missing Marker Information , 2000, Human Heredity.

[41]  M S McPeek,et al.  Estimation of variance components of quantitative traits in inbred populations. , 2000, American journal of human genetics.

[42]  K. Roeder,et al.  Genomic Control for Association Studies , 1999, Biometrics.

[43]  Mario Pirastu,et al.  Population choice in mapping genes for complex diseases , 1999, Nature Genetics.

[44]  D. Clayton,et al.  A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. , 1999, American journal of human genetics.

[45]  D. Clayton,et al.  Transmission/disequilibrium tests for extended marker haplotypes. , 1999, American journal of human genetics.

[46]  Leena Peltonen,et al.  Positional Cloning of Disease Genes: Advantages of Genetic Isolates , 1999, Human Heredity.

[47]  L. Almasy,et al.  Multipoint quantitative-trait linkage analysis in general pedigrees. , 1998, American journal of human genetics.

[48]  P. Sasieni.  From genotypes to genes: doubling the sample size. , 1997, Biometrics.

[49]  E. Feingold,et al.  Genome scanning for segments shared identical by descent among distant relatives in isolated populations. , 1997, American journal of human genetics.

[50]  M. Walter,et al.  Identification of the human chromosomal region containing the iridogoniodysgenesis anomaly locus by genomic-mismatch scanning. , 1997, American journal of human genetics.

[51]  E. Génin,et al.  Information provided by pairs of distantly affected relatives to search for genes involved in rare autosomal dominant diseases , 1997, Annals of human genetics.

[52]  W J Ewens,et al.  The TDT and other family-based tests for linkage disequilibrium and association. , 1996, American journal of human genetics.

[53]  E. Génin,et al.  Consanguinity and the sib-pair method: an approach using identity by descent between and within individuals. , 1996, American journal of human genetics.

[54]  K Lange,et al.  Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. , 1996, American journal of human genetics.

[55]  E. Génin,et al.  Association studies in consanguineous populations. , 1996, American journal of human genetics.

[56]  J. A. Woodward,et al.  A general statistical model for detecting complex-trait loci by using affected relative pairs in a genome search. , 1996, American journal of human genetics.

[57]  C. Amos.  Robust variance-components approach for assessing genetic linkage in pedigrees. , 1994, American journal of human genetics.

[58]  S. Nelson,et al.  Genomic mismatch scanning: a new approach to genetic linkage mapping , 1993, Nature Genetics.

[59]  W. Ewens,et al.  Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). , 1993, American journal of human genetics.

[60]  P. Armitage.  Tests for Linear Trends in Proportions and Frequencies , 1955 .

[61]  D. Gudbjartsson,et al.  A susceptibility gene for psoriatic arthritis maps to chromosome 16q: evidence for imprinting. , 2003, American journal of human genetics.

[62]  T D Dyer,et al.  GAW12: Simulated Genome Scan, Sequence, and Family Data for a Common Disease , 2001, Genetic epidemiology.

[63]  E. Wijsman,et al.  The Importance of Connections: Joining Components of the Hutterite Pedigree , 2001, Genetic epidemiology.

[64]  E. Génin,et al.  Use of closely related affected individuals for the genetic study of complex diseases in founder populations. , 2001, American journal of human genetics.

[65]  T D Dyer,et al.  The Effect of Pedigree Complexity on Quantitative Trait Linkage Analysis , 2001, Genetic epidemiology.

[66]  L. Almasy,et al.  Robust LOD scores for variance component‐based linkage analysis , 2000, Genetic epidemiology.

[67]  M S McPeek,et al.  Optimal allele‐sharing statistics for genetic mapping using affected relatives , 1999, Genetic epidemiology.

[68]  S. Iturria,et al.  An empirical test of the significance of an observed quantitative trait locus effect that preserves additive genetic variation , 1999, Genetic epidemiology.

[69]  S. Nelson,et al.  Genomic mismatch scanning identifies human genomic DNA shared identical by descent. , 1998, Genomics.

[70]  E. Wijsman,et al.  MCMC segregation and linkage analysis , 1997, Genetic epidemiology.