Antioxidant levels in peripheral blood, disease activity and fibrotic stage in chronic hepatitis C

Background: This study addressed the suggested association between levels of the antioxidants glutathione (GSH), vitamin C and vitamin E in peripheral blood and the histological activity and fibrosis stage in chronic hepatitis C (CHC). We then determined whether regular antioxidant supplementation influenced these antioxidant levels or disease severity.

[1]  H. Jaeschke,et al.  The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. , 2003, Toxicology letters.

[2]  M. Evans,et al.  Oxidative DNA damage: mechanisms, mutation, and disease , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[3]  P. Pemberton,et al.  Oxidant stress is a significant feature of primary biliary cirrhosis. , 2003, Biochimica et biophysica acta.

[4]  J. George,et al.  Interaction of iron, insulin resistance, and nonalcoholic steatohepatitis , 2003, Current gastroenterology reports.

[5]  T. Asselah,et al.  Fibrosis and disease progression in hepatitis C , 2002 .

[6]  T. Asselah,et al.  Fibrosis and disease progression in hepatitis C , 2002, Hepatology.

[7]  F. Wrba,et al.  Hepatocellular fat accumulation and low serum cholesterol in patients infected with HCV-3a , 2002, American Journal of Gastroenterology.

[8]  C. Lieber S-adenosyl-L-methionine: its role in the treatment of liver disorders. , 2002, The American journal of clinical nutrition.

[9]  J. Hoofnagle,et al.  Use of complementary and alternative medicine in patients with liver disease , 2002, American Journal of Gastroenterology.

[10]  P. Pemberton,et al.  Oxidative stress in chronic hepatitis C: not just a feature of late stage disease. , 2002, Journal of hepatology.

[11]  M. Cappellini,et al.  Red blood cell antioxidant and iron status in alcoholic and nonalcoholic cirrhosis , 2002, European journal of clinical investigation.

[12]  J. Kaldor,et al.  Estimating progression to cirrhosis in chronic hepatitis C virus infection , 2001, Hepatology.

[13]  J. Hoofnagle,et al.  Complementary and alternative medicine in chronic liver disease , 2001, Hepatology.

[14]  G. Robino,et al.  Oxidative stress-related molecules and liver fibrosis. , 2001, Journal of hepatology.

[15]  Z. Goodman,et al.  Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis c. , 2001, Journal of hepatology.

[16]  G. Cioni,et al.  Antioxidant liposoluble vitamins and carotenoids in chronic hepatitis. , 2001, European journal of internal medicine.

[17]  S. I. Lee,et al.  Oxidative stress effect on the activation of hepatic stellate cells. , 2001, Yonsei medical journal.

[18]  P. Portincasa,et al.  Oxidative stress in symptom‐free HCV carriers: relation with ALT flare‐up , 2001, European journal of clinical investigation.

[19]  G. Marchesini,et al.  Synthesis of glutathione in response to methionine load in control subjects and in patients with cirrhosis. , 2000, Metabolism: clinical and experimental.

[20]  M. Zaretsky,et al.  N‐acetylcysteine replenishes glutathione in HIV infection , 2000, European journal of clinical investigation.

[21]  E. Mosharov,et al.  The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes. , 2000, Biochemistry.

[22]  D. Purdie,et al.  Host genetic factors influence disease progression in chronic hepatitis C , 2000, Hepatology.

[23]  S. French,et al.  Mechanisms of alcoholic liver injury. , 2000, Canadian journal of gastroenterology = Journal canadien de gastroenterologie.

[24]  O. Griffith,et al.  Biologic and pharmacologic regulation of mammalian glutathione synthesis. , 1999, Free radical biology & medicine.

[25]  H. Sies,et al.  Glutathione and its role in cellular functions. , 1999, Free radical biology & medicine.

[26]  G. Filice,et al.  Hepatocellular mitochondrial alterations in patients with chronic hepatitis C: ultrastructural and biochemical findings , 1999, American Journal of Gastroenterology.

[27]  R. Brigelius-Flohé,et al.  Vitamin E: function and metabolism , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[28]  G. Barbarini,et al.  Serum ferritin and hepatic glutathione concentrations in chronic hepatitis C patients related to the hepatitis C virus genotype. , 1999, Journal of hepatology.

[29]  T. Yoshikawa,et al.  Oxidative stress in patients with hepatitis, cirrhosis, and hepatoma evaluated by plasma antioxidants. , 1998, Biochemical and biophysical research communications.

[30]  J. Kench,et al.  How much does alcohol contribute to the variability of hepatic fibrosis in chronic hepatitis C? , 1998, Journal of gastroenterology and hepatology.

[31]  F. Ridolfi,et al.  Fibrogenic effect of oxidative stress on rat hepatic stellate cells , 1998, Hepatology.

[32]  V. Paradis,et al.  In situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features. , 1997, Journal of clinical pathology.

[33]  J. Juszczyk,et al.  Reduced glutathione concentration in erythrocytes of patients with acute and chronic viral hepatitis , 1997, Journal of viral hepatitis.

[34]  C. Niederau,et al.  Diminished plasma levels of vitamin E in patients with severe viral hepatitis. , 1996, Free radical research.

[35]  G. Barbarini,et al.  Hepatic glutathione deficiency in chronic hepatitis C: quantitative evaluation in patients who are HIV positive and HIV negative and correlations with plasmatic and lymphocytic concentrations and with the activity of the liver disease. , 1996, The American journal of gastroenterology.

[36]  B. Mills,et al.  Differential distribution of free and bound glutathione and cyst(e)ine in human blood. , 1996, Biochemical pharmacology.

[37]  C. Del Vecchio Blanco,et al.  Effect of alcohol abuse and glutathione administration on the circulating levels of glutathione and on antipyrine metabolism in patients with alcoholic liver cirrhosis. , 1996, Scandinavian journal of clinical and laboratory investigation.

[38]  M. Zoli,et al.  Defective methionine metabolism in cirrhosis: Relation to severity of liver disease , 1992, Hepatology.

[39]  P. Scheuer,et al.  Classification of chronic viral hepatitis: a need for reassessment. , 1991, Journal of hepatology.

[40]  T. Toyo’oka,et al.  High-performance liquid chromatography and fluorometric detection of biologically important thiols, derivatized with ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate (SBD-F). , 1983, Journal of chromatography.

[41]  V. Raisys,et al.  Ascorbic acid in lymphocytes: cell preparation and liquid-chromatographic assay. , 1982, Clinical chemistry.

[42]  J. Henderson,et al.  Evidence for impairment of transsulfuration pathway in cirrhosis , 1981 .

[43]  M. Anderson,et al.  Dynamic state of glutathione in blood plasma. , 1980, The Journal of biological chemistry.

[44]  J P de la Cruz,et al.  Effects of silymarin MZ-80 on oxidative stress in patients with alcoholic cirrhosis. Results of a randomized, double-blind, placebo-controlled clinical study. , 2002, International journal of clinical pharmacology and therapeutics.

[45]  R. Mulcahy,et al.  The enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase. , 1999, Advances in enzymology and related areas of molecular biology.

[46]  N. Kaplowitz,et al.  Role of the Liver in Interorgan Homeostasis of Glutathione and Cyst(e)ine , 1998, Seminars in liver disease.

[47]  C. Lieber Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases. , 1997, Advances in pharmacology.

[48]  D. V. van Thiel,et al.  Association between reactive oxygen species and disease activity in chronic hepatitis C. , 1996, Free radical biology & medicine.

[49]  S. Heymsfield,et al.  Evidence for impairment of transsulfuration pathway in cirrhosis. , 1981, Gastroenterology.

[50]  L. Holmberg,et al.  Determination of plasma α-tocopherol by high-performance liquid chromatography , 1978 .

[51]  L. Holmberg,et al.  Determination of plasma alpha-tocopherol by high-performance liquid chromatography. , 1978, Journal of Chromatography A.