COMPARISON OF DIFFERENT CLASSIFICATION SYSTEMS IN PREDICTING THE OUTCOME OF DIABETIC FOOT ULCERS – RESULTS OF AN OBSERVATIONAL STUDY

Aim: To compare three ulcer classification systems as predictors of the outcome of diabetic foot ulcers: University of Texas, PEDIS (perfusion, extent/size, depth/ tissue loss, infection, sensation) and IDSA (Infectious Diseases Society of America) infection grading system. Material and methods: Ulcer area, depth, appearance, infection and associated ischemia and neuropathy were recorded in a consecutive series of 150 subjects hospitalized with foot ulcer between January 2014 and June 2016. Presence of osteolysis was assessed by foot X-ray. Results: Mean age of the study patients was 60.67 years; 101 (68.2%) were male. Most ulcers (75.7%) were treated conservatively, while 36 (24.3%) subjects underwent amputation. Significant differences between patients with amputation and those conservatively treated were observed with regard to depth (p<0.001) and extent of lesions (p<0.001) using the PEDIS system, Texas grade (p=0.005) and IDSA infection severity (p<0.001). All three classification systems predicted ulcer outcome (p<0.001). No differences were found between these three classifications in terms of predicting amputations in our study groupː PEDIS–ISDA (p=0.53), PEDIS–TEXAS (p=0.78) IDSA–TEXAS (p=0.62). Conclusions: All three systems predicted ulcer outcome, without obvious benefits of using a particular classification.

[1]  Hanish Kataria,et al.  Clinical Profile and Outcome in Patients of Diabetic Foot Infection , 2019, International journal of applied & basic medical research.

[2]  J. Garg,et al.  Outcomes of Wound Healing and Limb Loss After Transmetatarsal Amputation in the Presence of Peripheral Vascular Disease , 2019, The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons.

[3]  C. Machado,et al.  Risk factors for mortality among patients undergoing major amputations due to infected diabetic feet , 2018, Jornal vascular brasileiro.

[4]  Ş. Çetinkalp,et al.  Risk factors for amputation in patients with diabetic foot infection: a prospective study , 2017, International wound journal.

[5]  D. Azoicǎi,et al.  Negative Pressure Therapy in the Surgical Treatment of Diabetic Foot , 2017 .

[6]  E. Park,et al.  Comparison of five systems of classification of diabetic foot ulcers and predictive factors for amputation , 2017, International wound journal.

[7]  Dalong Zhu,et al.  Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis† , 2017, Annals of medicine.

[8]  D. Christofaro,et al.  Relationship between amputation and risk factors in individuals with diabetes mellitus: A study with Brazilian patients. , 2017, Diabetes & metabolic syndrome.

[9]  Xiaoqun He,et al.  Reliability and Validity of the Perfusion, Extent, Depth, Infection and Sensation (PEDIS) Classification System and Score in Patients with Diabetic Foot Ulcer , 2015, PloS one.

[10]  N. Forna,et al.  Presepsin as a Biomarker for Sepsis Evolutions in Diabetis , 2015 .

[11]  A. Petris,et al.  Associated factors of ejection fraction in insulin-treated patients with type 2 diabetes. , 2014, Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi.

[12]  K. A. Sriyani,et al.  Predictors of Diabetic Foot and Leg Ulcers in a Developing Country with a Rapid Increase in the Prevalence of Diabetes Mellitus , 2013, PloS one.

[13]  David G. Armstrong,et al.  Infectious Diseases Society of America Clinical Practice Guideline for the Diagnosis and Treatment of Diabetic Foot Infectionsa , 2012 .

[14]  T. Kohlmann,et al.  Prevalence of diabetic foot syndrome and its risk factors in the UK. , 2010, Journal of wound care.

[15]  H. Havitcioglu,et al.  Predictors of amputation in diabetics with foot ulcer: Single center experience in a large Turkish cohort , 2009, Hormones.

[16]  Truls Østbye,et al.  History of Foot Ulcer Increases Mortality Among Individuals With Diabetes , 2009, Diabetes Care.

[17]  D. Armstrong The University of Texas Diabetic Foot Classification System. , 1996, Ostomy/wound management.