P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice

[1]  M. Sur,et al.  Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice , 2019, Science Translational Medicine.

[2]  C. Marquette,et al.  Alternative splicing of P2RX7 pre-messenger RNA in health and diseases: Myth or reality? , 2019, Biomedical journal.

[3]  Yvan Saeys,et al.  A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment , 2019, Nature Neuroscience.

[4]  B. Sperlágh,et al.  P2X7 Receptors Drive Poly(I:C) Induced Autism-like Behavior in Mice , 2019, The Journal of Neuroscience.

[5]  K. Cadwell,et al.  Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges , 2019, The Journal of experimental medicine.

[6]  V. Abudara,et al.  Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword , 2018, Front. Mol. Neurosci..

[7]  M. Phillips,et al.  Ventral hippocampal projections to the medial prefrontal cortex regulate social memory , 2018, bioRxiv.

[8]  Weiguo Peng,et al.  Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension , 2018, Nature Communications.

[9]  F. Ginhoux,et al.  Microglia and early brain development: An intimate journey , 2018, Science.

[10]  C. Stadelmann,et al.  Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody , 2018, eLife.

[11]  Guang Yang,et al.  Contributions of monocytes to nervous system disorders , 2018, Journal of Molecular Medicine.

[12]  B. Delatour,et al.  New role of P2X7 receptor in an Alzheimer’s disease mouse model , 2018, Molecular Psychiatry.

[13]  B. Becher,et al.  Erratum: High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease (Immunity (2018) 48(2) (380–395.e6) (S1074761318300323) (10.1016/j.immuni.2018.01.011)) , 2018 .

[14]  G. Nolan,et al.  Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models , 2018, Nature Neuroscience.

[15]  B. Becher,et al.  High‐Dimensional Single‐Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease , 2018, Immunity.

[16]  L. Martínez-Alarcón,et al.  P2X7 Receptor Induces Tumor Necrosis Factor-α Converting Enzyme Activation and Release to Boost TNF-α Production , 2017, Front. Immunol..

[17]  F. Di Virgilio,et al.  The P2X7 Receptor in Infection and Inflammation , 2017, Immunity.

[18]  L. Ricceri,et al.  Persistent Unresolved Inflammation in the Mecp2-308 Female Mutated Mouse Model of Rett Syndrome , 2017, Mediators of inflammation.

[19]  Guang Yang,et al.  CX3CR1+ monocytes modulate learning and learning-dependent dendritic spine remodeling via TNFα , 2017, Nature Medicine.

[20]  Tuan Leng Tay,et al.  A new fate mapping system reveals context-dependent random or clonal expansion of microglia , 2017, Nature Neuroscience.

[21]  M. Prinz,et al.  Ontogeny and homeostasis of CNS myeloid cells , 2017, Nature Immunology.

[22]  T. Xu,et al.  Chronic Social Defeat Stress Modulates Dendritic Spines Structural Plasticity in Adult Mouse Frontal Association Cortex , 2017, Neural plasticity.

[23]  A. Bhattacharya,et al.  The microglial ATP‐gated ion channel P2X7 as a CNS drug target , 2016, Glia.

[24]  A. Bird,et al.  Exclusive expression of MeCP2 in the nervous system distinguishes between brain and peripheral Rett syndrome-like phenotypes , 2016, Human molecular genetics.

[25]  Steffen Jung,et al.  Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression , 2016, eLife.

[26]  Zhiping Weng,et al.  Unexpected role of interferon-γ in regulating neuronal connectivity and social behavior , 2016, Nature.

[27]  D. Henshall,et al.  Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models , 2016, PloS one.

[28]  S. Linnarsson,et al.  Origin, fate and dynamics of macrophages at central nervous system interfaces , 2016, Nature Immunology.

[29]  A. Verkhratsky,et al.  Purinergic neurone-glia signalling in cognitive-related pathologies , 2016, Neuropharmacology.

[30]  Guang Yang,et al.  FGF-1 Triggers Pannexin-1 Hemichannel Opening in Spinal Astrocytes of Rodents and Promotes Inflammatory Responses in Acute Spinal Cord Slices , 2016, The Journal of Neuroscience.

[31]  Hyunju Kim,et al.  The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring , 2016, Science.

[32]  G. Burnstock P2X ion channel receptors and inflammation , 2016, Purinergic Signalling.

[33]  H. Zoghbi,et al.  MECP2 disorders: from the clinic to mice and back. , 2015, The Journal of clinical investigation.

[34]  Michael J. Yetman,et al.  Wild-type microglia do not reverse pathology in mouse models of Rett syndrome , 2015, Nature.

[35]  Steffen Jung,et al.  Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli. , 2015, Immunity.

[36]  B. Sperlágh,et al.  P2X7 receptor: an emerging target in central nervous system diseases. , 2014, Trends in pharmacological sciences.

[37]  L. Pozzo-Miller,et al.  Dendritic spine dysgenesis in Rett syndrome , 2014, Front. Neuroanat..

[38]  U. Meyer Prenatal Poly(I:C) Exposure and Other Developmental Immune Activation Models in Rodent Systems , 2014, Biological Psychiatry.

[39]  David A. Orlando,et al.  Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. , 2013, Cell stem cell.

[40]  P. Bonaventure,et al.  Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ‐47965567 , 2013, British journal of pharmacology.

[41]  D. Centonze,et al.  Interleukin-1β Alters Glutamate Transmission at Purkinje Cell Synapses in a Mouse Model of Multiple Sclerosis , 2013, The Journal of Neuroscience.

[42]  W. Gan,et al.  Peripheral elevation of TNF-α leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitis , 2013, Proceedings of the National Academy of Sciences.

[43]  H. Zoghbi,et al.  Overexpression of Methyl-CpG Binding Protein 2 Impairs TH1 Responses , 2012, Science Translational Medicine.

[44]  M. Nedergaard,et al.  Connexin and pannexin hemichannels in inflammatory responses of glia and neurons , 2012, Brain Research.

[45]  Baljit S. Khakh,et al.  Neuromodulation by Extracellular ATP and P2X Receptors in the CNS , 2012, Neuron.

[46]  S. Nelson,et al.  A Critical and Cell-Autonomous Role for MeCP2 in Synaptic Scaling Up , 2012, The Journal of Neuroscience.

[47]  A. Nicke,et al.  Alternative Splicing of the N-Terminal Cytosolic and Transmembrane Domains of P2X7 Controls Gating of the Ion Channel by ADP-Ribosylation , 2012, PloS one.

[48]  F. Di Virgilio,et al.  P2X7 receptor‐stimulation causes fever via PGE2 and IL‐1β release , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[49]  D. Górecki,et al.  Expression, assembly and function of novel C‐terminal truncated variants of the mouse P2X7 receptor: re‐evaluation of P2X7 knockouts , 2012, British journal of pharmacology.

[50]  James C. Cronk,et al.  Wild type microglia arrest pathology in a mouse model of Rett syndrome , 2012, Nature.

[51]  G. Schmalzing,et al.  The Effect of Anions on the Human P2X7 Receptor , 2012 .

[52]  G. Schmalzing,et al.  The effect of anions on the human P2X7 receptor. , 2011, Biochimica et biophysica acta.

[53]  G. Dubyak,et al.  Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation , 2011, The Journal of Immunology.

[54]  C. Lord,et al.  Behavioural phenotyping assays for mouse models of autism , 2010, Nature Reviews Neuroscience.

[55]  W. Gan,et al.  Stably maintained dendritic spines are associated with lifelong memories , 2009, Nature.

[56]  J. Lupski,et al.  Autism and other neuropsychiatric symptoms are prevalent in individuals with MeCP2 duplication syndrome , 2009, Annals of neurology.

[57]  F. Holsboer,et al.  Dynamic DNA methylation programs persistent adverse effects of early-life stress , 2009, Nature Neuroscience.

[58]  M. Schaefer,et al.  Increase of intracellular Ca2+ by P2Y but not P2X receptors in cultured cortical multipolar neurons of the rat , 2009, The Journal of comparative neurology.

[59]  T. Takano,et al.  Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury , 2009, Proceedings of the National Academy of Sciences.

[60]  A. Nicke,et al.  A Functional P2X7 Splice Variant with an Alternative Transmembrane Domain 1 Escapes Gene Inactivation in P2X7 Knock-out Mice* , 2009, The Journal of Biological Chemistry.

[61]  F. Rossi,et al.  Local self-renewal can sustain CNS microglia maintenance and function throughout adult life , 2007, Nature Neuroscience.

[62]  Christina Thaller,et al.  Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome , 2006, Proceedings of the National Academy of Sciences.

[63]  H. Zoghbi,et al.  Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome. , 2005, Human molecular genetics.

[64]  S. Goldman,et al.  P2X7 receptor inhibition improves recovery after spinal cord injury , 2004, Nature Medicine.

[65]  Juan I. Young,et al.  Mice with Truncated MeCP2 Recapitulate Many Rett Syndrome Features and Display Hyperacetylation of Histone H3 , 2002, Neuron.

[66]  H. Zoghbi,et al.  Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 , 1999, Nature Genetics.

[67]  P Bailey,et al.  Double Edged Sword , 2002 .

[68]  A. Bird,et al.  MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin , 1997, Cell.

[69]  R. Riikonen,et al.  High levels of cerebrospinal fluid glutamate in Rett syndrome. , 1996, Pediatric neurology.

[70]  A. Bird,et al.  Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA , 1992, Cell.

[71]  O. Meurman,et al.  Long-term persistence of intrathecal viral antibody responses in postinfectious diseases of the central nervous system and in Rett syndrome. , 1989, Neuropediatrics.

[72]  G. Wagner,et al.  Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology , 2017, Journal of Molecular Medicine.

[73]  E. Kavalali,et al.  The Impact of MeCP2 Loss- or Gain-of-Function on Synaptic Plasticity , 2013, Neuropsychopharmacology.

[74]  A. Bird,et al.  A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome , 2001, Nature Genetics.